{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:58:38Z","timestamp":1792681118917,"version":"4.5.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n            <jats:title>Background.<\/jats:title>\n            <jats:p>Recipients of kidneys from living donors who subsequently develop end-stage renal disease (ESRD) also have higher graft failure, suggesting the 2 donor kidneys share risk factors that could inform recipient outcomes. Given that donor ESRD is rare, an earlier and more common postdonation outcome could serve as a surrogate to individualize counseling and management for recipients. Hypertension is a frequent event before donor ESRD; thus, early postdonation hypertension might indicate higher risk of graft failure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods.<\/jats:title>\n            <jats:p>We studied Scientific Registry of Transplant Recipients data to quantify the association between early postdonation hypertension and recipient graft failure using propensity score-weighted Cox proportional hazards regression. We also examined the association between postdonation systolic blood pressure and graft failure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results.<\/jats:title>\n            <jats:p>Of 37 901 recipients, 2.4% had a donor who developed hypertension within 2 years postdonation. Controlling for donor and recipient characteristics, recipients whose donors developed hypertension had no higher risk for graft failure (adjusted hazard ratio [aHR] 1.03, 95% confidence interval [CI] 0.85-1.25, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.72). This was consistent among subgroups of recipients at higher risk for adverse outcomes due to hyperfiltration: African American recipients (aHR 1.10, 95% CI 0.70-1.73, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.68) and those with ESRD caused by hypertension (aHR 1.10, 95% CI 0.65-1.85, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.73) or diabetes (aHR 0.80, 95% CI 0.56-1.13, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.20). However, graft failure was associated with postdonation systolic blood pressure (per 10 mm Hg, aHR 1.05, 95% CI 1.03-1.08, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions.<\/jats:title>\n            <jats:p>Although postdonation systolic blood pressure is associated with graft failure, the reported diagnosis of hypertension as determined by the requirement for blood pressure treatment early postdonation did not portend a higher risk of recipient graft failure in the same way as eventual postdonation ESRD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/tp.0000000000002832","type":"journal-article","created":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T21:36:31Z","timestamp":1563744991000},"page":"583-590","source":"Crossref","is-referenced-by-count":7,"title":["Association Between Living Kidney Donor Postdonation Hypertension and Recipient Graft Failure"],"prefix":"10.1097","volume":"104","author":[{"given":"Courtenay M.","family":"Holscher","sequence":"first","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanveen","family":"Ishaque","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Haugen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle R.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Garonzik Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawaz","family":"Al Ammary","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorry L.","family":"Segev","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."},{"name":"Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD."},{"name":"Scientific Registry of Transplant Recipients, Minneapolis, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan B.","family":"Massie","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."},{"name":"Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"12","key":"R1-20231002","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1111\/ajt.13869","article-title":"Recipient outcomes following transplantation of allografts from live kidney donors who subsequently developed end-stage renal disease.","volume":"16","author":"Muzaale","year":"2016","journal-title":"Am J Transplant"},{"issue":"6","key":"R2-20231002","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1001\/jama.2013.285141","article-title":"Risk of end-stage renal disease following live kidney donation.","volume":"311","author":"Muzaale","year":"2014","journal-title":"JAMA"},{"issue":"1","key":"R3-20231002","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ki.2013.460","article-title":"Long-term risks for kidney donors.","volume":"86","author":"Mj\u00f8en","year":"2014","journal-title":"Kidney Int"},{"key":"R4-20231002","article-title":"Early hypertension and diabetes after living kidney donation: a national cohort study.","author":"Holscher","year":"2018","journal-title":"Transplantation"},{"issue":"12","key":"R5-20231002","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1111\/ajt.13917","article-title":"Patterns of end-stage renal disease caused by diabetes, hypertension, and glomerulonephritis in live kidney donors.","volume":"16","author":"Anjum","year":"2016","journal-title":"Am J Transplant"},{"issue":"5","key":"R6-20231002","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/ajt.14671","article-title":"Causes and timing of 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models.","volume":"168","author":"Cole","year":"2008","journal-title":"Am J Epidemiol"},{"issue":"1","key":"R16-20231002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/biostatistics\/kxn014","article-title":"Effective communication of standard errors and confidence intervals.","volume":"10","author":"Louis","year":"2009","journal-title":"Biostatistics"},{"issue":"3","key":"R17-20231002","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI78885","article-title":"Longitudinal study of living kidney donor glomerular dynamics after nephrectomy.","volume":"125","author":"Lenihan","year":"2015","journal-title":"J Clin Invest"},{"issue":"3","key":"R18-20231002","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1172\/JCI80818","article-title":"Benign hyperfiltration after living kidney donation.","volume":"125","author":"Blantz","year":"2015","journal-title":"J Clin 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ancestry.","volume":"102","author":"Gaillard","year":"2018","journal-title":"Transplantation"},{"issue":"3","key":"R22-20231002","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/TP.0000000000002509","article-title":"Mechanisms of injury in APOL1-associated kidney disease.","volume":"103","author":"Ma","year":"2019","journal-title":"Transplantation"},{"issue":"6","key":"R23-20231002","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1097\/TP.0000000000001252","article-title":"Long-term outcomes of living kidney 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