{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T08:49:17Z","timestamp":1777798157393,"version":"3.51.4"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n            <jats:title>Background.<\/jats:title>\n            <jats:p>Chickenpox is a highly contagious vaccine-preventable disease that can lead to severe complications, especially in immunocompromised patients. Varicella-zoster virus (VZV) vaccine appears to be safe and immunogenic in pediatric solid organ transplant recipients, but there are few data on the long-term vaccine-induced seroprotection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods.<\/jats:title>\n            <jats:p>In this prospective interventional study, we offered 2 doses of VZV vaccine to all eligible and nonseroprotected children seen 1 year after liver transplant. Vaccine responses were measured 1 month later and yearly thereafter. Vaccine safety was closely monitored. A supplementary dose was administered if protective levels were not reached\/maintained.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results.<\/jats:title>\n            <jats:p>Among 121 enrolled patients, 49 were vaccinated and followed during 5.5 years (interquartile range, 3.7-8.0). Their seroconversion rate reached 100% (97.5% confidence interval [CI], 92.7-100). Low VZV-antibody concentration (\u2264400 UI\/L) after the first 1\u20132 dose\/s was associated with the need for a supplementary dose (odds ratio, 15.0; 95% CI, 3.4-67.0, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.001) and was given to 31% (15\/47) of children at 1.1 year (interquartile range, 0.9-3.9). Although antibody concentrations declined during follow-up, 96% (95% CI, 86.0-99.5) of patients maintained protective antibody concentrations at a median of 5.5 years after vaccination. One breakthrough disease was identified.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions.<\/jats:title>\n            <jats:p>VZV immunization of pediatric solid organ transplant recipients confers sustained seroprotection.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/tp.0000000000002866","type":"journal-article","created":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T21:36:31Z","timestamp":1563744991000},"page":"e355-e364","source":"Crossref","is-referenced-by-count":20,"title":["Long-term Seroprotection of Varicella-zoster Immunization in Pediatric Liver Transplant Recipients"],"prefix":"10.1097","volume":"103","author":[{"given":"Charlotte M.","family":"Verolet","sequence":"first","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics, Children\u2019s Hospital, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure F.","family":"Pittet","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics, Children\u2019s Hospital, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara E.","family":"Wildhaber","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Center of Pediatric Surgery of Western Switzerland."},{"name":"Children\u2019s Hospital, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie A.","family":"McLin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Transplantation, Department of Pediatrics, Children\u2019s Hospital, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics, Children\u2019s Hospital, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Grillet","sequence":"additional","affiliation":[{"name":"Departments of Pathology-Immunology and Pediatrics, Centre for Vaccinology, University of Geneva, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire-Anne","family":"Siegrist","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics, Children\u2019s Hospital, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland."},{"name":"Departments of Pathology-Immunology and Pediatrics, Centre for Vaccinology, University of Geneva, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klara M.","family":"Posfay-Barbe","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics, Children\u2019s Hospital, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20231002","first-page":"604","article-title":"Varicella vaccine (VARIVAX) in healthy children and adolescents: results from clinical trials, 1987 to 1989.","volume":"87","author":"White","year":"1991","journal-title":"Pediatrics"},{"issue":"Suppl 2","key":"R2-20231002","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.1086\/522125","article-title":"The safety profile of varicella vaccine: a 10-year review.","volume":"197","author":"Galea","year":"2008","journal-title":"J Infect Dis"},{"issue":"Suppl 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