{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:58:57Z","timestamp":1790974737291,"version":"4.1.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n            <jats:title>Background.<\/jats:title>\n            <jats:p>The concept of organ transplantation as treatment for complex genetic conditions, including Wolcott-Rallison syndrome (WRS), continues to show promise. Liver transplantation is essential for survival of patients with WRS, and pancreas transplantation cures their type I diabetes mellitus.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods.<\/jats:title>\n            <jats:p>The recipient, a 3-year-old girl weighing 14 kg at the time of transplantation, suffered from major complications of WRS, including repetitive liver failure episodes and poorly controlled diabetes. The patient underwent a nonacute, combined, simultaneous liver and pancreas transplantation from a pediatric donor without using the en bloc technique.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results.<\/jats:title>\n            <jats:p>Well-preserved graft functions at 2-year follow-up with normal liver and pancreas function.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions.<\/jats:title>\n            <jats:p>This is the first case report of simultaneous liver and pancreas transplantation as treatment of WRS in a small child in Europe. Two-year follow-up demonstrates that organ transplantation can halt life-threating recurrent liver failure episodes and cure type 1 diabetes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/tp.0000000000002869","type":"journal-article","created":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T21:36:31Z","timestamp":1563744991000},"page":"522-525","source":"Crossref","is-referenced-by-count":7,"title":["First European Case of Simultaneous Liver and Pancreas Transplantation as Treatment of Wolcott-Rallison Syndrome in a Small Child"],"prefix":"10.1097","volume":"104","author":[{"given":"Johan","family":"Nordstr\u00f6m","sequence":"first","affiliation":[{"name":"Division of Transplantation Surgery, CLINTEC, Karolinska Institutet and Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Clinical Research Centre, Lund University, Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Jorns","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery, CLINTEC, Karolinska Institutet and Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Fischler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Karolinska University Hospital and Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Arnell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Karolinska University Hospital and Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal","family":"Dlugosz","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery, CLINTEC, Karolinska Institutet and Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sandberg","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery, CLINTEC, Karolinska Institutet and Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Wennberg","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery, CLINTEC, Karolinska Institutet and Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Nowak","sequence":"additional","affiliation":[{"name":"Division of Transplantation Surgery, CLINTEC, Karolinska Institutet and Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20231002","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.2337\/diabetes.51.7.2301","article-title":"Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene.","volume":"51","author":"Biason-Lauber","year":"2002","journal-title":"Diabetes"},{"key":"R2-20231002","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/PL00008394","article-title":"Wolcott-Rallison syndrome: a case with endocrine and exocrine pancreatic deficiency and pancreatic 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