{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:34:13Z","timestamp":1784932453452,"version":"3.55.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n            <jats:title>Background.<\/jats:title>\n            <jats:p>In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly reduced the incidence of delayed graft function after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care end points.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods.<\/jats:title>\n            <jats:p>We assessed graft survival through 1 year of all solid organs transplanted from 370 donors who had been randomly assigned to hypothermia (34\u201335\u00b0C) or normothermia (36.5\u201337.5\u00b0C) before donation. Additionally, changes in standardized critical care end points were compared between donors in each group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results.<\/jats:title>\n            <jats:p>Mild hypothermia was associated with a nonsignificant improvement in 1-year kidney transplant survival (95% versus 92%; hazard ratio, 0.61 [0.31\u20131.20]; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.15). Mild hypothermia was associated with higher 1-year graft survival in the subgroup of standard criteria donors (97% versus 93%; hazard ratio, 0.39 [0.15 to \u22121.00]; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.05). There were no significant differences in graft survival of extrarenal organs. There were no differences in critical care end points between groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions.<\/jats:title>\n            <jats:p>Mild hypothermia in the donor safely reduced the rate of delayed graft function in kidney transplant recipients without adversely affecting donor physiology or extrarenal graft survival. Kidneys from standard criteria donors who received targeted mild hypothermia had improved 1-year graft survival.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/tp.0000000000002890","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T13:46:35Z","timestamp":1564407995000},"page":"e365-e368","source":"Crossref","is-referenced-by-count":22,"title":["Therapeutic Hypothermia in Organ Donors: Follow-up and Safety Analysis"],"prefix":"10.1097","volume":"103","author":[{"given":"Darren","family":"Malinoski","sequence":"first","affiliation":[{"name":"Section of Surgical Critical Care, VA Portland Healthcare System, Portland, OR."},{"name":"Division of Trauma, Critical Care, and Acute Care Surgery, Oregon Health and Science University, Portland, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhukar S.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Massachusetts General Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Axelrod","sequence":"additional","affiliation":[{"name":"University of Iowa Transplant Institute, Iowa City, IA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Broglio","sequence":"additional","affiliation":[{"name":"Berry Consultants, LLC, Austin, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Berry Consultants, LLC, Austin, TX."},{"name":"Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, CA."},{"name":"Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahnee","family":"Groat","sequence":"additional","affiliation":[{"name":"Section of Surgical Critical Care, VA Portland Healthcare System, Portland, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus U.","family":"Niemann","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA."},{"name":"Division of Transplantation, Department of Surgery, University of California San Francisco, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20231002","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1111\/ajt.12243","article-title":"Challenges to research and innovation to optimize deceased donor organ quality and quantity.","volume":"13","author":"Abt","year":"2013","journal-title":"Am J Transplant"},{"key":"R2-20231002","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/ajt.12566","article-title":"Research and innovation in the deceased donor.","volume":"14","author":"Gerber","year":"2014","journal-title":"Am J Transplant"},{"key":"R3-20231002","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/ajt.13482","article-title":"Deceased donor intervention research: a survey of transplant surgeons, organ procurement professionals, and institutional review board members.","volume":"16","author":"Rodrigue","year":"2016","journal-title":"Am J Transplant"},{"key":"R4-20231002","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/j.1600-6143.2010.03100.x","article-title":"Donor intervention and organ preservation: where is the science and what are the obstacles?","volume":"10","author":"Feng","year":"2010","journal-title":"Am J Transplant"},{"key":"R6-20231002","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1097\/TP.0000000000000841","article-title":"A framework for conducting deceased donor research in the United States.","volume":"99","author":"Glazier","year":"2015","journal-title":"Transplantation"},{"key":"R7-20231002","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1097\/TP.0000000000002512","article-title":"The continued need for clinical trials in deceased organ donor management.","volume":"103","author":"Niemann","year":"2019","journal-title":"Transplantation"},{"key":"R8-20231002","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1097\/TP.0000000000002511","article-title":"A randomized controlled trial of naloxone for optimization of hypoxemia in lung donors after brain death.","volume":"103","author":"Dhar","year":"2019","journal-title":"Transplantation"},{"key":"R9-20231002","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1056\/NEJMoa1501969","article-title":"Therapeutic hypothermia in deceased organ donors and kidney-graft function.","volume":"373","author":"Niemann","year":"2015","journal-title":"N Engl J 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analysis.","volume":"15","author":"Patel","year":"2015","journal-title":"Am J Transplant"},{"key":"R15-20231002","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.kint.2016.01.028","article-title":"The risk of allograft failure and the survival benefit of kidney transplantation are complicated by delayed graft function.","volume":"89","author":"Gill","year":"2016","journal-title":"Kidney Int"},{"key":"R16-20231002","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/ajt.14591","article-title":"Comments on \u201cimpact of spontaneous donor hypothermia on graft outcomes after kidney transplantation\u201d.","volume":"18","author":"Niemann","year":"2018","journal-title":"Am J Transplant"}],"container-title":["Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/TP.0000000000002890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:28:56Z","timestamp":1696224536000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/TP.0000000000002890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1097\/tp.0000000000002890","relation":{},"ISSN":["0041-1337"],"issn-type":[{"value":"0041-1337","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}