{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:44:29Z","timestamp":1793119469842,"version":"4.5.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7]]},"abstract":"\n Background.<\/jats:title>\n The vast majority of patients with cirrhosis have low Model for End-Stage Liver Disease\u2013Sodium (MELD-Na) scores; however, the ability for the MELD-Na score to predict patient outcomes at low scores is unclear.<\/jats:p>\n <\/jats:sec>\n \n Methods.<\/jats:title>\n Adult patients in a multicenter, Chicago-wide database of medical records with International Classification of Disease, Ninth Edition<\/jats:italic> codes of cirrhosis and without a history of hepatocellular carcinoma were included. Records were linked with the state death registry, and death certificates were manually reviewed. Deaths were classified as \u201cliver-related,\u201d \u201cnon-liver-related,\u201d and \u201cnon-descript\u201d as adjudicated by a panel comprised of a transplant surgeon, a hepatologist, and an internist. A sensitivity analysis was performed where patients with hepatocellular carcinoma were included.<\/jats:p>\n <\/jats:sec>\n \n Results.<\/jats:title>\n Among 7922 identified patients, 3999 patients had MELD-Na scores that were never higher than 15. In total, 2137 (27%) patients died during the study period with higher mortality rates for the patients in the high MELD-Na group (19.4 (41.6%) versus 4.1 (12.6%) per 100 person-y, P<\/jats:italic> < 0.001). The high MELD-Na group died of a liver-related cause in 1142 out of 1632 (70%) as compared to 240 out of 505 (47.5%) deaths in the low MELD-Na group. There was no difference in the distribution of subcategory of liver-related death between low and high MELD-Na groups. Among subclassification of liver-related deaths, the most common cause of death was \u201cInfectious\u201d in both groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusions.<\/jats:title>\n Despite persistently low MELD-Na scores, patients with cirrhosis still experience high rates of liver-related mortality.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/tp.0000000000002997","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T15:08:44Z","timestamp":1571843324000},"page":"1413-1418","source":"Crossref","is-referenced-by-count":40,"title":["Patients With Persistently Low MELD-Na Scores Continue to Be at Risk of Liver-related Death"],"prefix":"10.1097","volume":"104","author":[{"given":"Nikhilesh R.","family":"Mazumder","sequence":"first","affiliation":[{"name":"Northwestern University Transplant Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, IL."},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kofi","family":"Atiemo","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Daud","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Kho","sequence":"additional","affiliation":[{"name":"Center for Health Information Partnerships, Institute for Public Health and Medicine, Chicago, Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Abecassis","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Levitsky","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela P.","family":"Ladner","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, IL."},{"name":"Center for Healthcare Studies, Institute for Public Health and Medicine, Northwestern University, 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