{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T00:22:39Z","timestamp":1794615759077,"version":"4.9.1"},"reference-count":136,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Kidney allograft failure is a serious condition, as it implies the need for reinitiation of dialysis with associated morbidity and mortality, reduced quality of life, and higher economic cost. Despite improvements in short-term survival of kidney allografts, this progress was not matched in long-term graft survival. In this viewpoint article, we summarize the available literature on the causes of kidney allograft failure, both early and late, both nonimmune and alloimmune, to gain better insight into the causes of graft failure. Such insight is necessary to better target therapies or take preventative measures that improve long-term outcome after kidney transplantation.<\/jats:p>","DOI":"10.1097\/tp.0000000000003012","type":"journal-article","created":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T13:43:27Z","timestamp":1571579007000},"page":"e46-e56","source":"Crossref","is-referenced-by-count":70,"title":["The Causes of Kidney Allograft Failure: More Than Alloimmunity. A Viewpoint Article"],"prefix":"10.1097","volume":"104","author":[{"given":"Elisabet","family":"Van Loon","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium."},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelle","family":"Bernards","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaryllis H.","family":"Van Craenenbroeck","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium."},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Naesens","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium."},{"name":"Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"10","key":"R1-20231002","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1681\/ASN.2014080771","article-title":"A lifetime of allograft function with kidneys from older donors.","volume":"26","author":"Rose","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"R2-20231002","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.trre.2018.08.001","article-title":"Indications, risks and impact of failed allograft nephrectomy.","volume":"33","author":"Ghyselen","year":"2019","journal-title":"Transplant Rev 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