{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T16:28:28Z","timestamp":1749313708126,"version":"3.41.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n            <jats:title>Background.<\/jats:title>\n            <jats:p>Donors with drowning or asphyxiation (DA) as a mechanism of death (MOD) are considered high risk in pediatric lung transplantation. We sought to evaluate whether recipients of DA donors had negatively impacted outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods.<\/jats:title>\n            <jats:p>Pediatric recipients recorded in the United Network for Organ Sharing registry between 2000 and 2019 were included. Primary stratification was donor MOD. Propensity matching with a 1:1 ratio was performed to balance the DA and non-DA MOD donor cohorts. Cox multivariable regression was used to determine the risk-adjusted impact of donor MOD. A subanalysis of the effect of lung allocation score was also evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results.<\/jats:title>\n            <jats:p>A total of 1016 patients underwent bilateral lung transplantation during the study period, including 888 (85.6%) from non-DA donors and 128 (14.4%) from DA donors. Survival at 90 days, 1 year, and 2 years were similar in the matched and unmatched cohorts regardless of the donor MOD. Moreover, separate risk-adjusted analysis of drowning and asphyxiated donors was similar to other MOD donors at 30 days, 1 year, and 5 years. Similar survival findings persisted regardless of pretransplant lung allocation score. Although the rates of posttransplant stroke (1.0% versus 3.1%, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.04) and the length of hospital stay (19 versus 22 d, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.004) were elevated in the unmatched DA MOD recipients, these differences were mitigated after propensity matching.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions.<\/jats:title>\n            <jats:p>This study evaluated the impact of DA MOD donors in pediatric lung transplant recipients and found similar rates of complications and survival in a propensity-matched cohort. These data collectively support the consideration of DA MOD donors for use in pediatric lung transplantation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/tp.0000000000003262","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T05:16:08Z","timestamp":1587014168000},"page":"620-627","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of Donor Asphyxiation or Drowning on Pediatric Lung Transplant Recipients"],"prefix":"10.1097","volume":"105","author":[{"given":"Laura","family":"Seese","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arman","family":"Kilic","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harma K.","family":"Turbendian","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiothoracic Surgery, University of Pittsburgh Medical Center, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA."},{"name":"Division of Pediatric Cardiothoracic Surgery, University of Pittsburgh Medical Center, Wolfson Children\u2019s Hospital, Jacksonville, FL."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo G.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Division of Lung Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Diaz-Castrillon","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiothoracic Surgery, University of Pittsburgh Medical Center, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor O.","family":"Morell","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiothoracic Surgery, University of Pittsburgh Medical Center, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA."},{"name":"Division of Pediatric Cardiothoracic Surgery, University of Pittsburgh Medical Center, Wolfson Children\u2019s Hospital, Jacksonville, FL."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2020,4,13]]},"reference":[{"key":"R1-20250604","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S1053-2498(03)00096-2","article-title":"A review of lung transplant donor acceptability criteria.","volume":"22","author":"Orens","year":"2003","journal-title":"J Heart Lung Transplant"},{"key":"R2-20250604","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/ajt.13507","article-title":"Broader geographic sharing of 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