{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:03:15Z","timestamp":1793678595923,"version":"4.5.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n            <jats:title>Background.<\/jats:title>\n            <jats:p>Donor hepatectomy and liver implantation time reduce long-term graft and patient survival after liver transplantation. It is not known whether these surgical times influence early outcomes after liver transplantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods.<\/jats:title>\n            <jats:p>This single-center study evaluated the effect of donor hepatectomy and implantation time on the risk of nonanastomotic biliary strictures (NAS) occurring within 1 year and of early allograft dysfunction (EAD) after deceased-donor solitary liver transplantation, adjusting for other donors, recipient, and surgical factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results.<\/jats:title>\n            <jats:p>Of 917 transplants performed between January 2000 and December 2016, 106 (11.56%) developed NAS and 247 (27%) developed EAD. Donor hepatectomy time (median 35 min, IQR: 26\u201346) was an independent risk factor of NAS [adjusted hazard ratio, 1.19; 95% CI, 1.04-1.35; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.01]. Implantation time (median 80 min, IQR: 69\u201395) was independently associated with EAD [adjusted odds ratio (OR), 1.15; 95% CI,1.07-1.23; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.0001). The risk of EAD was increased by anastomosis time of both portal vein (adjusted OR, 1.26; 95% CI, 1.12-14.42; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.0001) and hepatic artery (adjusted OR, 1.13; 95% CI, 1.04-1.22; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.005). The magnitude of these effects was similar in donation after circulatory death liver grafts.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions.<\/jats:title>\n            <jats:p>Donor hepatectomy and implantation time negatively affect short-term outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/tp.0000000000003335","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T21:34:27Z","timestamp":1591220067000},"page":"1030-1038","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":29,"title":["Donor Hepatectomy and Implantation Time Are Associated With Early Complications After Liver Transplantation: A Single-center Retrospective Study"],"prefix":"10.1097","volume":"105","author":[{"given":"Nicholas","family":"Gilbo","sequence":"first","affiliation":[{"name":"Lab of Abdominal Transplantation, Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium."},{"name":"Abdominal Transplantation Surgery and Coordination, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Fieuws","sequence":"additional","affiliation":[{"name":"Department of Public Health, Interuniversity Centre for Biostatistics and Statistical Bioinformatics, KU Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Meurisse","sequence":"additional","affiliation":[{"name":"Department of Abdominal Transplant Surgery, University of Liege Academic Hospital, Li\u00e8ge, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Nevens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schalk","family":"van der Merwe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Laleman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Verslype","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cassiman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"van Malenstein","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Roskams","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Sainz-Barriga","sequence":"additional","affiliation":[{"name":"Lab of Abdominal Transplantation, Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium."},{"name":"Abdominal Transplantation Surgery and Coordination, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Pirenne","sequence":"additional","affiliation":[{"name":"Lab of Abdominal Transplantation, Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium."},{"name":"Abdominal Transplantation Surgery and Coordination, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Jochmans","sequence":"additional","affiliation":[{"name":"Lab of Abdominal Transplantation, Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium."},{"name":"Abdominal Transplantation Surgery and Coordination, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diethard","family":"Monbaliu","sequence":"additional","affiliation":[{"name":"Lab of Abdominal Transplantation, Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium."},{"name":"Abdominal Transplantation Surgery and Coordination, University Hospitals Leuven, Leuven, 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