{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:53:52Z","timestamp":1766087632305,"version":"3.41.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n            <jats:title>Background.<\/jats:title>\n            <jats:p>Transplant recipients with HIV may have worse outcomes with coronavirus disease 2019 (COVID-19) due to impaired T-cell function coupled with immunosuppressive drugs. Alternatively, immunosuppression might reduce inflammatory complications and\/or antiretrovirals could be protective.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods.<\/jats:title>\n            <jats:p>Prospective reporting of all cases of SARS-CoV-2 infection was required within the HOPE in Action Multicenter Consortium, a cohort of kidney and liver transplant recipients with HIV who have received organs from donors with and without HIV at 32 transplant centers in the United States.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results.<\/jats:title>\n            <jats:p>Between March 20, 2020 and September 25, 2020, there were 11 COVID-19 cases among 291 kidney and liver recipients with HIV (4%). In those with COVID-19, median age was 59 y, 10 were male, 8 were kidney recipients, and 5 had donors with HIV. A higher proportion of recipients with COVID-19 compared with the overall HOPE in the Action cohort were Hispanic (55% versus 12%) and received transplants in New York City (73% versus 34%, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05). Most (10\/11, 91%) were hospitalized. High-level oxygen support was required in 7 and intensive care in 5; 1 participant opted for palliative care instead of transfer to the intensive care unit. HIV RNA was undetectable in all. Median absolute lymphocyte count was 0.3 \u00d7 10<jats:sup>3<\/jats:sup> cells\/\u03bcL. Median CD4 pre\u2013COVID-19 was 298 cells\/\u03bcL, declining to &lt;200 cells\/\u03bcl in 6\/7 with measurements on admission. Treatment included high-dose steroids (n = 6), tocilizumab (n = 3), remdesivir (n = 2), and convalescent plasma (n = 2). Four patients (36%) died.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions.<\/jats:title>\n            <jats:p>Within a national prospective cohort of kidney and liver transplant recipients with HIV, we report high mortality from COVID-19.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/tp.0000000000003527","type":"journal-article","created":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T20:03:07Z","timestamp":1604865787000},"page":"216-224","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":21,"title":["Incidence and Outcomes of COVID-19 in Kidney and Liver Transplant Recipients With HIV: Report From the National HOPE in Action Consortium"],"prefix":"10.1097","volume":"105","author":[{"given":"Sapna A.","family":"Mehta","sequence":"first","affiliation":[{"name":"New York University Langone Transplant Institute, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenakshi M.","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer D.","family":"Motter","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine B.","family":"Small","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Division of Infectious Diseases, Weill Cornell Medicine, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Division of Infectious Diseases, Columbia University Irving Medical Center, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Stosor","sequence":"additional","affiliation":[{"name":"Divisions of Infectious Diseases and Organ Transplantation Feinberg School of Medicine, Northwestern University, Chicago, IL."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahel","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplant Center, Massachusetts General Hospital, Boston, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandy","family":"Haydel","sequence":"additional","affiliation":[{"name":"Recanati\/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sander","family":"Florman","sequence":"additional","affiliation":[{"name":"Recanati\/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonah","family":"Odim","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Transplantation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Morsheimer","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Transplantation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Robien","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Transplantation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan B.","family":"Massie","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Boyarsky","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Garonzik-Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron A.R.","family":"Tobian","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Werbel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorry L.","family":"Segev","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Durand","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the HOPE in Action 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