{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T04:16:23Z","timestamp":1749096983943,"version":"3.41.0"},"reference-count":65,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n            <jats:title>Background.<\/jats:title>\n            <jats:p>Human cytomegalovirus (CMV) infection is associated with renal allograft dysfunction and loss, particularly in combination with acute rejection. Emerging literature suggests that non-HLA antibodies may contribute to antibody-mediated rejection, but pathogen-induced antibodies have not been investigated in this context. This study examines the presence of CMV-induced antibodies in murine CMV (MCMV)\u2013infected renal allografts during acute rejection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods.<\/jats:title>\n            <jats:p>Intragraft immunoglobulin G (IgG) and complement C3 immunostaining were compared among allogeneic MCMV D<jats:sup>\u2212<\/jats:sup>\/R<jats:sup>\u2212<\/jats:sup>, D<jats:sup>+<\/jats:sup>\/R<jats:sup>\u2212<\/jats:sup>, and D<jats:sup>+<\/jats:sup>\/R<jats:sup>+<\/jats:sup> renal transplants. Intragraft antibody deposition was examined in B cell\u2013deficient recipients treated with MCMV immune sera. Antibody binding and complement-dependent cytotoxicity (CDC) of D<jats:sup>\u2212<\/jats:sup>\/R<jats:sup>\u2212<\/jats:sup> and D<jats:sup>+<\/jats:sup>\/R<jats:sup>+<\/jats:sup> sera against infected renal tubular epithelial cells (TECs) were measured in vitro. IgG immunostaining was performed in D<jats:sup>+<\/jats:sup>\/R<jats:sup>+<\/jats:sup> allografts and native kidneys and in D<jats:sup>+<\/jats:sup>\/R<jats:sup>\u2212<\/jats:sup> allografts treated with ganciclovir to inhibit viral replication.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results.<\/jats:title>\n            <jats:p>D<jats:sup>+<\/jats:sup>\/R<jats:sup>\u2212<\/jats:sup> and D<jats:sup>+<\/jats:sup>\/R<jats:sup>+<\/jats:sup> transplants had more abundant IgG and C3 deposition compared with D<jats:sup>\u2212<\/jats:sup>\/R<jats:sup>\u2212<\/jats:sup> recipients. Greater IgG deposition was associated with more severe allograft injury in B cell\u2013deficient recipients treated with MCMV immune sera compared with nonimmune sera. D<jats:sup>+<\/jats:sup>\/R<jats:sup>+<\/jats:sup> sera induced greater CDC of infected TECs compared with D<jats:sup>\u2212<\/jats:sup>\/R<jats:sup>\u2212<\/jats:sup> sera. Native kidneys had lower IgG deposition compared with allografts, despite similar organ viral loads. Ganciclovir-treated allografts had reduced IgG deposition compared with untreated allografts.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions.<\/jats:title>\n            <jats:p>In this murine model, complement-fixing antibodies can deposit into MCMV-infected renal allografts, are associated with allograft damage, and can induce CDC of MCMV-infected renal TECs. The allogeneic response and viral replication may also contribute to intragraft antibody deposition.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/tp.0000000000003548","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T04:58:06Z","timestamp":1605934686000},"page":"1718-1729","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Murine Cytomegalovirus\u2013induced Complement-fixing Antibodies Deposit in Murine Renal Allografts During Acute Rejection"],"prefix":"10.1097","volume":"105","author":[{"given":"Ute","family":"Saunders","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivasa R.","family":"Boddeda","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonya","family":"Maher","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Ghere","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Kaptsan","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Dhital","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Velazquez","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Guo","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trenton R.","family":"Schoeb","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Alabama at Birmingham, Birmingham, AL."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Cianciolo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Shimamura","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH."},{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"R1-20250604","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1111\/j.1600-6143.2009.02824.x","article-title":"The \u2018indirect\u2019 effects of cytomegalovirus infection.","volume":"9","author":"Freeman","year":"2009","journal-title":"Am J Transplant"},{"key":"R2-20250604","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/00007890-200208270-00026","article-title":"The association of viral 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biopsies.","volume":"27","author":"Erdbruegger","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"R12-20250604","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.nefro.2016.11.018","article-title":"Cytomegalovirus infection after kidney transplantation and long-term graft loss.","volume":"37","author":"L\u00f3pez-Oliva","year":"2017","journal-title":"Nefrologia"},{"key":"R13-20250604","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1186\/s12879-017-2599-y","article-title":"Cytomegalovirus viraemia and mortality in renal transplant recipients in the era of antiviral prophylaxis. 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