{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:29:13Z","timestamp":1791559753315,"version":"4.3.4"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background.<\/jats:title>\n                    <jats:p>Advances in surgical and medical technology over the years has made liver transplantation possible for older and higher risk patients. Despite rigorous preoperative cardiac testing, cardiovascular events remain a major cause of death after orthotopic liver transplantation (OLT). However, there are little data on the outcomes of OLT in patients with preexisting coronary artery disease (CAD). This study aimed to compare all-cause and cardiovascular mortality of patients with and without history of CAD undergoing OLT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Six hundred ninety-three adult patients with cirrhosis underwent liver transplantation between July 2013 and December 2018 (female n\u2009=\u2009243, male n\u2009=\u2009450; median age 59).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      During the study period of 5 y (median follow-up, 24.1 mo), 92 of 693 patients (13.3%) died. All-cause mortality in the CAD group was significantly higher than in the non-CAD group (26.7% versus 9.6%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.01). Cardiovascular events accounted for 52.5% of deaths (n\u2009=\u200921) in patients with CAD compared with 36.5% (n\u2009=\u200919) in non-CAD patients. At 6 mo, patients with combined nonalcoholic steatohepatitis (NASH)\/CAD had significantly worse survival than those with CAD or NASH alone (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.01). After 6 mo, patients with CAD alone had similar survival to those with combined NASH\/CAD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Patients with preexisting CAD before liver transplantation are at higher risk of death from any cause, specifically cardiovascular-related death. This risk increases with coexisting NASH. The presence of NASH and CAD at the time of liver transplant should prompt the initiation of aggressive risk factor modification for patients with CAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/tp.0000000000004402","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T02:08:10Z","timestamp":1668737290000},"page":"933-940","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Outcomes of Liver Transplantation in Patients With Preexisting Coronary Artery Disease"],"prefix":"10.1097","volume":"107","author":[{"given":"Emily","family":"Reznicek","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce","family":"Montane","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Sims","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Beard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maan","family":"Fares","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cleveland Clinic, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Sharma","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Cywinski","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Cleveland Clinic, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiano","family":"Quintini","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Ohio, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico N.","family":"Aucejo","sequence":"additional","affiliation":[{"name":"Digestive Disease and Surgical Institute, Cleveland Clinic Foundation, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijan","family":"Eghtesad","sequence":"additional","affiliation":[{"name":"Digestive Disease and Surgical Institute, Cleveland Clinic Foundation, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Miller","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Ohio, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.V. Narayanan","family":"Menon","sequence":"additional","affiliation":[{"name":"Digestive Disease and Surgical Institute, Cleveland Clinic Foundation, Cleveland, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"R1-20250604","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart disease and stroke statistics\u20142018 update: a report from the American Heart Association.","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"R2-20250604","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1111\/j.1600-6143.2008.02276.x","article-title":"Predictive value of dobutamine stress echocardiography for coronary artery disease detection in liver transplant candidates.","volume":"8","author":"Harinstein","year":"2008","journal-title":"Am J Transplant"},{"key":"R3-20250604","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/lt.500020604","article-title":"Morbidity and mortality in patients with coronary artery disease undergoing orthotopic liver transplantation.","volume":"2","author":"Plotkin","year":"1996","journal-title":"Liver Transpl Surg"},{"key":"R4-20250604","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1097\/SLA.0000000000000265","article-title":"Liver transplantation in highest acuity recipients: identifying factors to avoid futility.","volume":"259","author":"Petrowsky","year":"2014","journal-title":"Ann Surg"},{"key":"R5-20250604","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1016\/j.transproceed.2008.08.129","article-title":"Influence of coronary artery disease on outcomes after liver transplantation.","volume":"40","author":"Diedrich","year":"2008","journal-title":"Transplant Proc"},{"key":"R6-20250604","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/lt.23997","article-title":"Adverse cardiac events after orthotropic liver transplantation: a cross-sectional study in 389 consecutive patients.","volume":"21","author":"Nicolau-Raducu","year":"2015","journal-title":"Liver Transpl"},{"key":"R7-20250604","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2459\/JCM.0000000000000207","article-title":"The impact of coronary artery disease on outcomes after liver transplantation.","volume":"17","author":"Skaro","year":"2016","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"R8-20250604","article-title":"Liver transplantation at Cleveland clinic.","volume":"195","author":"Hashimoto","year":"2010","journal-title":"Clin Transpl"},{"key":"R9-20250604","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1634\/theoncologist.2009-0211","article-title":"Conditional survival among cancer patients in the United States.","volume":"15","author":"Merrill","year":"2010","journal-title":"Oncologist"},{"key":"R10-20250604","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/lt.23873","article-title":"Role of cardiac catheterization and percutaneous coronary intervention in the preoperative assessment and management of patients before orthotopic liver transplantation.","volume":"20","author":"Maddur","year":"2014","journal-title":"Liver Transpl"},{"key":"R11-20250604","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0735-1097(88)90356-7","article-title":"Angiographic progression of coronary artery disease and the development of myocardial infarction.","volume":"12","author":"Ambrose","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"R12-20250604","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jacc.2005.03.074","article-title":"Atherothrombosis and high-risk plaque. Part I: evolving concepts.","volume":"46","author":"Fuster","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"R13-20250604","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/01.CIR.101.9.948","article-title":"Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction.","volume":"101","author":"Suwaidi","year":"2000","journal-title":"Circulation"},{"key":"R14-20250604","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/lt.22468","article-title":"Cumulative risk of cardiovascular events after orthotopic liver transplantation.","volume":"18","author":"Albeldawi","year":"2012","journal-title":"Liver Transpl"},{"key":"R15-20250604","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/lt.23950","article-title":"High early cardiovascular mortality after liver transplantation.","volume":"20","author":"Van Wagner","year":"2014","journal-title":"Liver Transpl"},{"key":"R16-20250604","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1097\/TP.0000000000001710","article-title":"Incidence of and risk assessment for adverse cardiovascular outcomes after liver transplantation: a systematic review.","volume":"101","author":"Konerman","year":"2017","journal-title":"Transplantation"},{"key":"R17-20250604","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.surg.2018.04.039","article-title":"Early mortality after liver transplantation: defining the course and the cause.","volume":"164","author":"Baganate","year":"2018","journal-title":"Surgery"},{"key":"R18-20250604","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1097\/TP.0000000000001647","article-title":"Outcome of liver transplant recipients with revascularized coronary artery disease: a comparative analysis with and without cardiovascular risk factors.","volume":"101","author":"Satapathy","year":"2017","journal-title":"Transplantation"},{"key":"R19-20250604","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejim.2017.12.001","article-title":"Pretransplant coronary artery disease is a predictor for myocardial infarction and cardiac death after liver transplantation.","volume":"51","author":"Darstein","year":"2018","journal-title":"Eur J Intern Med"},{"key":"R20-20250604","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/lt.25012","article-title":"Coronary artery disease in decompensated patients undergoing liver transplantation evaluation.","volume":"24","author":"Patel","year":"2018","journal-title":"Liver Transpl"},{"key":"R21-20250604","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1148\/radiol.09090769","article-title":"Presence of coronary plaques in patients with nonalcoholic fatty liver disease.","volume":"254","author":"Assy","year":"2010","journal-title":"Radiology"},{"key":"R22-20250604","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1136\/gut.2011.242016","article-title":"Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease.","volume":"60","author":"Wong","year":"2011","journal-title":"Gut"},{"key":"R23-20250604","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/MCA.0b013e3282583c0d","article-title":"Association between nonalcoholic fatty liver disease and coronary artery disease.","volume":"18","author":"Arslan","year":"2007","journal-title":"Coron Artery Dis"},{"key":"R24-20250604","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1002\/hep.25855","article-title":"Patients transplanted for nonalcoholic steatohepatitis are at increased risk for postoperative cardiovascular events.","volume":"56","author":"Vanwagner","year":"2012","journal-title":"Hepatology"},{"key":"R25-20250604","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4254\/wjh.v6.i1.41","article-title":"Hepato-cardiac disorders.","volume":"6","author":"Fouad","year":"2014","journal-title":"World J Hepatol"},{"key":"R26-20250604","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/00007890-199303000-00013","article-title":"Systemic versus nonsystemic reperfusion of the transplanted liver.","volume":"55","author":"Brems","year":"1993","journal-title":"Transplantation"},{"key":"R27-20250604","first-page":"185","article-title":"Cardiac arrest after graft reperfusion during liver transplantation.","volume":"5","author":"Shi","year":"2006","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"R28-20250604","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jacc.2011.03.026","article-title":"Cardiovascular risk assessment of the liver transplant candidate.","volume":"58","author":"Raval","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"R29-20250604","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/lt.24137","article-title":"Cardiovascular disease after liver transplantation: when, what, and who is at risk.","volume":"21","author":"Fussner","year":"2015","journal-title":"Liver Transpl"},{"key":"R30-20250604","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1600-6143.2012.04293.x","article-title":"Liver transplantation outcome in patients with angiographically proven coronary artery disease: a multi-institutional study.","volume":"13","author":"Wray","year":"2013","journal-title":"Am J Transplant"},{"key":"R31-20250604","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/liv.14092","article-title":"The relationship between coronary artery disease and cardiovascular events early after liver transplantation.","volume":"39","author":"Patel","year":"2019","journal-title":"Liver Int"}],"container-title":["Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/TP.0000000000004402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T14:12:52Z","timestamp":1749046372000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/TP.0000000000004402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,14]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1097\/tp.0000000000004402","relation":{},"ISSN":["0041-1337"],"issn-type":[{"value":"0041-1337","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,14]]}}}