{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:35:09Z","timestamp":1780068909124,"version":"3.54.0"},"reference-count":72,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>In patients with severe acute respiratory distress syndrome caused by coronavirus 2019 (COVID-19), mortality remains high despite optimal medical management. Extracorporeal membrane oxygenation (ECMO) has been widely used to support such patients. ECMO is not a perfect solution; however, there are several limitations and serious complications associated with ECMO use. Moreover, the overall short-term mortality rate of patients with COVID-19 supported by ECMO is high (~30%). Some patients who survive severe acute respiratory distress syndrome have chronic lung failure requiring oxygen supplementation, long-term mechanical ventilation, or ECMO support. Although lung transplant remains the most effective treatment for patients with end-stage lung failure from COVID-19, optimal patient selection and transplant timing for patients with COVID-19-related lung failure are not clear. Access to an artificial lung (AL) that can be used for long-term support as a bridge to transplant, bridge to recovery, or even destination therapy will become increasingly important. In this review, we discuss why the COVID-19 pandemic may drive progress in AL technology, challenges to AL implementation, and how some of these challenges might be overcome.<\/jats:p>","DOI":"10.1097\/tp.0000000000004606","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T04:00:38Z","timestamp":1681358438000},"page":"1278-1285","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Artificial Lungs for Lung Failure in the Era of COVID-19 Pandemic: Contemporary Review"],"prefix":"10.1097","volume":"107","author":[{"given":"Noritsugu","family":"Naito","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, NYU Langone Health, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihisa","family":"Shigemura","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Temple University Health System\/Lewis Katz 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