{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T13:55:34Z","timestamp":1752674134467,"version":"3.41.0"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n            <jats:title>Background.<\/jats:title>\n            <jats:p>Bariatric surgery (BS) is the optimal approach for sustained weight loss and may alter donation candidacy in potential donors with obesity. We evaluated the long-term effects of nephrectomy after BS on metabolic profile, including body mass index, serum lipids and diabetes, and kidney function of donors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods.<\/jats:title>\n            <jats:p>This was a single-center retrospective study. Live kidney donors who underwent BS before nephrectomy were matched for age, gender, and body mass index with patients who underwent BS alone and with donors who underwent nephrectomy alone. Estimated glomerular filtration rate (eGFR) was calculated according to Chronic Kidney Disease Epidemiology Collaboration and adjusted to individual body surface area to create absolute eGFR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results.<\/jats:title>\n            <jats:p>Twenty-three patients who underwent BS before kidney donation were matched to 46 controls who underwent BS alone. At the last follow-up, the study group showed significantly worse lipid profile with low-density lipoprotein of 115\u2009\u00b1\u200925\u2009mg\/dL versus the control group with low-density lipoprotein of 99\u2009\u00b1\u200929\u2009mg\/dL (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.036) and mean total cholesterol of 191\u2009\u00b1\u200932 versus 174\u2009\u00b1\u200933\u2009mg\/dL (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.046). The second control group of matched nonobese kidney donors (n\u2009=\u200972) had similar serum creatinine, eGFR, and absolute eGFR as the study group before nephrectomy and 1 y after the procedure. At the end of follow-up, the study group had significantly higher absolute eGFR compared with the control group (86\u2009\u00b1\u200921 versus 76\u2009\u00b1\u200918\u2009mL\/min; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.02) and similar serum creatinine and eGFR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions.<\/jats:title>\n            <jats:p>BS before live kidney donation is a safe procedure that could increase the donor pool and improve their health in the long run. Donors should be encouraged to maintain their weight and avoid adverse lipid profile and hyperfiltration.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/tp.0000000000004645","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T04:00:30Z","timestamp":1686283230000},"page":"2018-2027","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Bariatric Surgery in Severely Obese Kidney Donors Before Kidney Transplantation: A Retrospective Study"],"prefix":"10.1097","volume":"107","author":[{"given":"Dana","family":"Bielopolski","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension, Rabin Medical Center, Petah-Tikva, Israel."},{"name":"Department of Medicine, Medical School, Tel-Aviv University, Tel-Aviv, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renana","family":"Yemini","sequence":"additional","affiliation":[{"name":"Department of Surgery, Assuta Medical Center Ashdod, Israel."},{"name":"Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aviad","family":"Gravetz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical School, Tel-Aviv University, Tel-Aviv, Israel."},{"name":"Department of Transplant Surgery, Rabin Medical Center, Petach-Tikva, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oz","family":"Yoskovitch","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery, Rabin Medical Center, Petach-Tikva, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Keidar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Assuta Medical Center Ashdod, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idan","family":"Carmeli","sequence":"additional","affiliation":[{"name":"Department of Surgery, Assuta Medical Center Ashdod, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eytan","family":"Mor","sequence":"additional","affiliation":[{"name":"Department of Surgery B, Transplant Center, Sheba Medical Center, Ramat-Gan, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Rahamimov","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Rabin Medical Center, Petah-Tikva, Israel."},{"name":"Department of Medicine, Medical School, Tel-Aviv University, Tel-Aviv, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benaya","family":"Rozen-Zvi","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Rabin Medical Center, Petah-Tikva, Israel."},{"name":"Department of Medicine, Medical School, Tel-Aviv University, Tel-Aviv, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eviatar","family":"Nesher","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical School, Tel-Aviv University, Tel-Aviv, Israel."},{"name":"Department of Transplant Surgery, Rabin Medical Center, Petach-Tikva, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"R1-20250604","first-page":"1","article-title":"Prevalence of obesity and severe obesity among adults: United States, 2017-2018.","author":"Hales","year":"2020","journal-title":"NCHS Data Brief"},{"key":"R2-20250604","doi-asserted-by":"crossref","first-page":"155217","DOI":"10.1016\/j.metabol.2022.155217","article-title":"update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and 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