{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:39:20Z","timestamp":1784036360124,"version":"3.55.0"},"reference-count":136,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>With the growth of the older adult population, the number of older adults waitlisted for and undergoing kidney and liver transplantation has increased. Transplantation is an important and definitive treatment for this population. We present a contemporary review of the unique preoperative, intraoperative, and postoperative issues that patients older than 65 y face when they undergo kidney or liver transplantation. We focus on geriatric syndromes that are common in older patients listed for kidney or liver transplantation including frailty, sarcopenia, and cognitive dysfunction; discuss important considerations for older transplant recipients, which may impact preoperative risk stratification; and describe unique challenges in intraoperative and postoperative management for older patients. Intraoperative challenges in the older adult include using evidence-based best anesthetic practices, maintaining adequate perfusion pressure, and using minimally invasive surgical techniques. Postoperative concerns include controlling acute postoperative pain; preventing cardiovascular complications and delirium; optimizing immunosuppression; preventing perioperative kidney injury; and avoiding nephrotoxicity and rehabilitation. Future studies are needed throughout the perioperative period to identify interventions that will improve patients\u2019 preoperative physiologic status, prevent postoperative medical complications, and improve medical and patient-centered outcomes in this vulnerable patient population.<\/jats:p>","DOI":"10.1097\/tp.0000000000005000","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T15:00:58Z","timestamp":1711983658000},"page":"e346-e356","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Perioperative Considerations in Older Kidney and Liver Transplant Recipients: A Review"],"prefix":"10.1097","volume":"108","author":[{"given":"Emily L.","family":"Chanan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Perioperative Care and Pain Medicine, NYU Grossman School of Medicine, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gebhard","family":"Wagener","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Whitlock","sequence":"additional","affiliation":[{"name":"Department of Anesthesia & Perioperative Care, University of California, San Francisco, San Francisco, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C.","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Surgery, NYU Grossman School of Medicine, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara A.","family":"McAdams-DeMarco","sequence":"additional","affiliation":[{"name":"Department of Surgery, NYU Grossman School of Medicine, New York, NY."},{"name":"Department of Population Health, NYU Grossman School of Medicine, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative Care and Pain Medicine, NYU Grossman School of Medicine, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Nunnally","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative Care and Pain Medicine, NYU Grossman School of Medicine, New York, NY."},{"name":"Department of Surgery, NYU Grossman School of Medicine, New York, NY."},{"name":"Department of Neurology, NYU Grossman School of Medicine, New York, NY."},{"name":"Department of Medicine, NYU Grossman School of Medicine, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"R1-20250604","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1111\/j.1600-6143.2012.04245.x","article-title":"Solid-organ transplantation in older adults: current status and future research.","volume":"12","author":"Abecassis","year":"2012","journal-title":"Am J Transplant"},{"key":"R2-20250604","doi-asserted-by":"crossref","first-page":"e701","DOI":"10.1097\/TXD.0000000000001156","article-title":"Frailty and kidney transplantation: a systematic review and meta-analysis.","volume":"7","author":"Quint","year":"2021","journal-title":"Transplant Direct"},{"key":"R3-20250604","doi-asserted-by":"crossref","first-page":"293","DOI":"10.7326\/M13-1133","article-title":"Chronic hepatitis C virus infection in the united states, national health and nutrition examination survey 2003 to 2010.","volume":"160","author":"Denniston","year":"2014","journal-title":"Ann Intern Med"},{"key":"R4-20250604","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1053\/j.gastro.2015.10.043","article-title":"Aging of liver transplant registrants and recipients: trends and impact on waitlist outcomes, post-transplantation outcomes, and transplant-related survival benefit.","volume":"150","author":"Su","year":"2016","journal-title":"Gastroenterology"},{"key":"R5-20250604","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1002\/lt.23551","article-title":"Projected future increase in aging hepatitis C virus\u2013infected liver transplant candidates: a potential effect of hepatocellular carcinoma.","volume":"18","author":"Biggins","year":"2012","journal-title":"Liver Transpl"},{"key":"R6-20250604","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/lt.22435","article-title":"Excellent posttransplant survival for patients with nonalcoholic steatohepatitis in the United States.","volume":"18","author":"Afzali","year":"2012","journal-title":"Liver transplant"},{"key":"R7-20250604","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1053\/j.gastro.2011.06.061","article-title":"Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States.","volume":"141","author":"Charlton","year":"2011","journal-title":"Gastroenterology"},{"key":"R8-20250604","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1053\/j.gastro.2008.02.013","article-title":"Liver transplantation for hepatocellular carcinoma: impact of the MELD allocation system and predictors of survival.","volume":"134","author":"Ioannou","year":"2007","journal-title":"Gastroenterology"},{"key":"R9-20250604","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1007\/s11255-022-03208-2","article-title":"Dialysis or kidney transplantation in older adults? A systematic review summarizing functional, psychological, and quality of life-related outcomes after start of kidney replacement therapy.","volume":"54","author":"Schoot","year":"2022","journal-title":"Int Urol Nephrol"},{"key":"R10-20250604","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1053\/j.ajkd.2013.03.022","article-title":"Comparison of life participation activities among adults treated by hemodialysis, peritoneal dialysis, and kidney transplantation: a systematic review.","volume":"62","author":"Purnell","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"R11-20250604","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/ajt.15198","article-title":"Report from the American Society of Transplantation on frailty in solid organ transplantation.","volume":"19","author":"Kobashigawa","year":"2019","journal-title":"Am J Transplant"},{"key":"R12-20250604","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/TP.0000000000001003","article-title":"Frailty and transplantation.","volume":"100","author":"Exterkate","year":"2016","journal-title":"Transplantation"},{"key":"R13-20250604","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype.","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol Ser"},{"key":"R14-20250604","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1503\/cmaj.050051","article-title":"A global clinical measure of fitness and frailty in elderly people.","volume":"173","author":"Rockwood","year":"2005","journal-title":"Can Me\u0301d Assoc J"},{"key":"R15-20250604","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1213\/ANE.0000000000004602","article-title":"Frailty for perioperative clinicians: a narrative review.","volume":"130","author":"McIsaac","year":"2020","journal-title":"Anesth Analg"},{"key":"R16-20250604","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1177\/0898264312438551","article-title":"Validity and reliability of the short physical performance battery in two diverse older adult populations in Quebec and Brazil.","volume":"24","author":"Freire","year":"2012","journal-title":"J Aging Health"},{"key":"R17-20250604","article-title":"Multicenter study of age, frailty, and waitlist mortality among liver transplant candidates.","volume":"271","author":"Haugen","year":"2019","journal-title":"Ann Surg"},{"key":"R18-20250604","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/hep.29219","article-title":"Development of a novel frailty index to predict mortality in patients with end-stage liver disease.","volume":"66","author":"Lai","year":"2017","journal-title":"Hepatology"},{"key":"R19-20250604","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1097\/TP.0000000000002213","article-title":"Frailty, inflammatory markers, and waitlist mortality among patients with end-stage renal disease in a prospective cohort study.","volume":"102","author":"McAdams-DeMarco","year":"2018","journal-title":"Transplantation"},{"key":"R20-20250604","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1097\/TP.0000000000001546","article-title":"Individual frailty components and mortality in kidney transplant recipients.","volume":"101","author":"McAdams-DeMarco","year":"2017","journal-title":"Transplantation"},{"key":"R21-20250604","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1097\/SLA.0000000000002025","article-title":"Frailty, length of stay, and mortality in kidney transplant recipients.","volume":"266","author":"McAdams-DeMarco","year":"2017","journal-title":"Ann Surg"},{"key":"R22-20250604","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/ajt.14430","article-title":"Pre-kidney transplant lower extremity impairment and post-kidney transplant mortality.","volume":"18","author":"Nastasi","year":"2018","journal-title":"Am J Transplant"},{"key":"R23-20250604","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1111\/ajt.12762","article-title":"Frailty predicts waitlist mortality in liver transplant candidates.","volume":"14","author":"Lai","year":"2014","journal-title":"Am J Transplant"},{"key":"R24-20250604","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jhep.2018.12.009","article-title":"Age and liver transplantation.","volume":"70","author":"Durand","year":"2019","journal-title":"J Hepatol"},{"issue":"Suppl 1","key":"R25-20250604","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/geroni\/igab046.2050","article-title":"Transplant centers that measure frailty as part of clinical practice have better outcomes.","volume":"5","author":"Chen","year":"2021","journal-title":"Innovat Aging"},{"key":"R26-20250604","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1093\/ndt\/gfaa016","article-title":"An overview of frailty in kidney transplantation: measurement, management and future considerations.","volume":"35","author":"Harhay","year":"2020","journal-title":"Nephrol Dialysis Transplant"},{"key":"R27-20250604","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fnut.2019.00169","article-title":"Frailty and sarcopenia in older patients receiving kidney transplantation.","volume":"6","author":"Gandolfini","year":"2019","journal-title":"Front Nutrit"},{"key":"R28-20250604","first-page":"e20055","article-title":"Evaluation of sarcopenia in renal transplant recipients.","volume":"6","author":"Ozkayar","year":"2018","journal-title":"Nephrourol Mon"},{"key":"R29-20250604","doi-asserted-by":"crossref","first-page":"e14373","DOI":"10.1097\/MD.0000000000014373","article-title":"Association of loss of muscle mass with mortality in liver cirrhosis without or before liver transplantation.","volume":"98","author":"Chang","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"R30-20250604","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1111\/ajt.13732","article-title":"Systematic review and meta-analysis of the impact of computed tomography\u2013assessed skeletal muscle mass on outcome in patients awaiting or undergoing liver transplantation.","volume":"16","author":"van Vugt","year":"2016","journal-title":"Am J Transplant"},{"key":"R31-20250604","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.jhep.2014.02.026","article-title":"Prognostic value of muscle atrophy in cirrhosis using psoas muscle thickness on computed tomography.","volume":"60","author":"Durand","year":"2014","journal-title":"J Hepatol"},{"key":"R32-20250604","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/lt.23752","article-title":"Association between sarcopenia and the risk of serious infection among adults undergoing liver transplantation.","volume":"19","author":"Krell","year":"2013","journal-title":"Liver transplant"},{"key":"R33-20250604","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1213\/ANE.0000000000005197","article-title":"Agreement between the mini-cog in the preoperative clinic and on the day of surgery and association with postanesthesia care unit delirium: a cohort study of cognitive screening in older adults.","volume":"132","author":"Tiwary","year":"2020","journal-title":"Anesth Analg"},{"key":"R34-20250604","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1097\/ALN.0000000000003523","article-title":"Brief preoperative screening for frailty and cognitive impairment predicts delirium after spine surgery.","volume":"133","author":"Susano","year":"2020","journal-title":"Anesthesiology"},{"key":"R35-20250604","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/ALN.0000000000001859","article-title":"Poor performance on a preoperative cognitive screening test predicts postoperative complications in older orthopedic surgical patients.","volume":"127","author":"Culley","year":"2017","journal-title":"Anesthesiology"},{"key":"R36-20250604","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1213\/ANE.0000000000001277","article-title":"Preoperative cognitive stratification of older elective surgical patients.","volume":"123","author":"Culley","year":"2016","journal-title":"Anesth Analg"},{"key":"R37-20250604","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1046\/j.1532-5415.2003.51465.x","article-title":"The mini-cog as a screen for dementia: validation in a population-based sample.","volume":"51","author":"Borson","year":"2003","journal-title":"J Am Geriatr Soc"},{"key":"R38-20250604","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12916-016-0745-9","article-title":"Cognition in chronic kidney disease: a systematic review and meta-analysis.","volume":"14","author":"Berger","year":"2016","journal-title":"BMC Med"},{"key":"R39-20250604","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1097\/TP.0000000000002431","article-title":"Kidney transplant outcomes in recipients with cognitive impairment.","volume":"103","author":"Thomas","year":"2018","journal-title":"Transplantation"},{"key":"R40-20250604","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s40472-020-00274-2","article-title":"Cognitive function in liver transplantation.","volume":"7","author":"Albhaisi","year":"2020","journal-title":"Curr Transplant Report"},{"key":"R41-20250604","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/lt.25626","article-title":"Hepatic encephalopathy is reversible in the long term after liver transplantation.","volume":"25","author":"Hopp","year":"2019","journal-title":"Liver Transplant"},{"key":"R42-20250604","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/hep4.1796","article-title":"Cognitive impairment and physical frailty in patients with cirrhosis.","volume":"6","author":"Berry","year":"2022","journal-title":"Hepatol Commun"},{"key":"R43-20250604","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1053\/j.ajkd.2014.12.013","article-title":"Cancer incidence among US Medicare ESRD patients receiving hemodialysis, 1996-2009.","volume":"65","author":"Butler","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"R44-20250604","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1158\/1055-9965.EPI-21-0044","article-title":"Solid organ transplantation and survival among individuals with a history of cancer.","volume":"30","author":"Engels","year":"2021","journal-title":"Cancer Epidemiol Biomarkers Prevent"},{"key":"R45-20250604","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1001\/jama.2011.1592","article-title":"Spectrum of cancer risk among US solid organ transplant recipients.","volume":"306","author":"Engels","year":"2011","journal-title":"JAMA"},{"key":"R46-20250604","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jamcollsurg.2019.06.001","article-title":"Impact of pre-transplant malignancy on outcomes after kidney transplantation: united network for organ sharing database analysis.","volume":"229","author":"Livingston-Rosanoff","year":"2019","journal-title":"J Am Coll Surg"},{"key":"R47-20250604","doi-asserted-by":"crossref","first-page":"a015677","DOI":"10.1101\/cshperspect.a015677","article-title":"Cancer in the transplant recipient.","volume":"3","author":"Chapman","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"R48-20250604","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/ajt.13978","article-title":"Cancer screening recommendations for solid organ transplant recipients: a systematic review of clinical practice guidelines.","volume":"17","author":"Acuna","year":"2017","journal-title":"Am J Transplant"},{"key":"R49-20250604","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/ajt.16318","article-title":"Pretransplant solid organ malignancy and organ transplant candidacy: a consensus expert opinion statement.","volume":"21","author":"Al-Adra","year":"2021","journal-title":"Am J Transplant"},{"key":"R50-20250604","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/CIRCULATIONAHA.108.847178","article-title":"Perioperative risk predictors of cardiac outcomes in patients undergoing liver transplantation surgery.","volume":"120","author":"Safadi","year":"2009","journal-title":"Circulation"},{"key":"R51-20250604","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1111\/ajt.13779","article-title":"Factors associated with major adverse cardiovascular events after liver transplantation among a national sample.","volume":"16","author":"VanWagner","year":"2016","journal-title":"Am J Transplant"},{"key":"R52-20250604","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/lt.23950","article-title":"High early cardiovascular mortality after liver transplantation.","volume":"20","author":"VanWagner","year":"2014","journal-title":"Liver Transplant"},{"key":"R53-20250604","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jacc.2012.05.008","article-title":"Cardiac disease evaluation and management among kidney and liver transplantation candidates a scientific statement from the American Heart Association and the American College of Cardiology Foundation.","volume":"60","author":"Lentine","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"R54-20250604","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/ajt.14531","article-title":"Multidisciplinary approach to cardiac and pulmonary vascular disease risk assessment in liver transplantation: an evaluation of the evidence and consensus recommendations.","volume":"18","author":"VanWagner","year":"2018","journal-title":"Am J Transplant"},{"key":"R55-20250604","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.amjcard.2006.01.089","article-title":"Cardiac hemodynamic and coronary angiographic characteristics of patients being evaluated for liver transplantation.","volume":"98","author":"Tiukinhoy-Laing","year":"2006","journal-title":"Am J Cardiol"},{"key":"R56-20250604","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jacc.2011.03.026","article-title":"Cardiovascular risk assessment of the liver transplant candidate.","volume":"58","author":"Raval","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"R57-20250604","doi-asserted-by":"crossref","first-page":"e299","DOI":"10.1161\/CIR.0000000000001104","article-title":"Emerging evidence on coronary heart disease screening in kidney and liver transplantation candidates: a scientific statement from the American Heart Association.","volume":"146","author":"Cheng","year":"2022","journal-title":"Circulation"},{"key":"R58-20250604","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0140-6736(17)32713-7","article-title":"Drug-eluting stents in elderly patients with coronary artery disease (SENIOR): a randomised single-blind trial.","volume":"391","author":"Varenne","year":"2018","journal-title":"Lancet"},{"key":"R59-20250604","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ahj.2020.09.019","article-title":"Design and rationale of the XIENCE short DAPT clinical program: an assessment of the safety of 3-month and 1-month DAPT in patients at high bleeding risk undergoing PCI with an everolimus-eluting stent.","volume":"231","author":"Valgimigli","year":"2021","journal-title":"Am Heart J"},{"key":"R60-20250604","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s11748-022-01783-w","article-title":"Combined cardiac surgery procedures and liver transplant: a single-center experience.","volume":"70","author":"Jacob","year":"2022","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"R61-20250604","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/lt.20244","article-title":"Safety and efficacy of combined orthotopic liver transplantation and coronary artery bypass grafting.","volume":"10","author":"Axelrod","year":"2004","journal-title":"Liver Transplant"},{"key":"R62-20250604","doi-asserted-by":"crossref","first-page":"e0148","DOI":"10.1097\/HC9.0000000000000148","article-title":"Progression to cirrhosis is similar among all ages in nonalcoholic fatty liver disease, but liver-related events increase with age.","volume":"7","author":"Miller","year":"2023","journal-title":"Hepatol Commun"},{"key":"R63-20250604","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jhep.2021.04.029","article-title":"Current knowledge and management of portal vein thrombosis in cirrhosis.","volume":"75","author":"Senzolo","year":"2021","journal-title":"J Hepatol"},{"key":"R64-20250604","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s10620-015-4012-2","article-title":"Direct oral anticoagulants in cirrhosis patients pose similar risks of bleeding when compared to traditional anticoagulation.","volume":"61","author":"Intagliata","year":"2016","journal-title":"Dig Dis Sci"},{"key":"R65-20250604","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/hepr.12895","article-title":"Efficacy and safety of edoxaban for treatment of portal vein thrombosis following danaparoid sodium in patients with liver cirrhosis.","volume":"48","author":"Nagaoki","year":"2018","journal-title":"Hepatol Res"},{"key":"R66-20250604","doi-asserted-by":"crossref","first-page":"e931648-1","DOI":"10.12659\/AOT.931648","article-title":"Is continuing anticoagulation or antiplatelet therapy safe prior to kidney transplantation?","volume":"26","author":"Alonso-Escalante","year":"2021","journal-title":"Ann Transplant"},{"key":"R67-20250604","doi-asserted-by":"crossref","first-page":"100594","DOI":"10.1016\/j.trre.2020.100594","article-title":"Comparison of the effect of single vs dual antiplatelet agents on post-operative haemorrhage after renal transplantation: a systematic review and meta-analysis.","volume":"35","author":"Lee","year":"2021","journal-title":"Transplant Rev"},{"key":"R68-20250604","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1002\/lt.26521","article-title":"Deceased donor liver transplantation in patients on direct oral anticoagulants at the time of transplant surgery: a case series.","volume":"28","author":"Salerno","year":"2022","journal-title":"Liver Transplant"},{"key":"R69-20250604","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s40472-023-00395-4","article-title":"Prehabilitation in adult solid organ transplant candidates.","volume":"10","author":"Quint","year":"2023","journal-title":"Curr Transplant Reports"},{"key":"R70-20250604","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1139\/apnm-2015-0084","article-title":"Optimization of surgical outcomes with prehabilitation.","volume":"40","author":"Mina","year":"2015","journal-title":"Appl Physiol Nutrit Metabol"},{"key":"R71-20250604","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jand.2015.06.007","article-title":"Prehabilitation with whey protein supplementation on perioperative functional exercise capacity in patients undergoing colorectal resection for cancer: a pilot double-blinded randomized placebo-controlled trial.","volume":"116","author":"Gillis","year":"2016","journal-title":"J Acad Nutr Diet"},{"key":"R72-20250604","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.anclin.2019.04.004","article-title":"Multimodal prehabilitation programs for older surgical patients.","volume":"37","author":"Borrell-Vega","year":"2019","journal-title":"Anesthesiol Clin"},{"key":"R73-20250604","doi-asserted-by":"crossref","first-page":"e13450","DOI":"10.1111\/ctr.13450","article-title":"Prehabilitation prior to kidney transplantation: results from a pilot study.","volume":"33","author":"McAdams-DeMarco","year":"2019","journal-title":"Clin Transplant"},{"key":"R74-20250604","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.gerinurse.2021.08.019","article-title":"Maintenance phase of a physical activity intervention in older kidney transplant recipients: a 12-month follow-up.","volume":"42","author":"O\u2019Brien","year":"2021","journal-title":"Geriatr Nurs"},{"key":"R75-20250604","doi-asserted-by":"crossref","first-page":"10330","DOI":"10.3389\/ti.2022.10330","article-title":"Physical effects, safety and feasibility of prehabilitation in patients awaiting orthotopic liver transplantation: a systematic review.","volume":"35","author":"Jetten","year":"2022","journal-title":"Transplant Int"},{"key":"R76-20250604","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12877-017-0621-2","article-title":"What is polypharmacy? A systematic review of definitions.","volume":"17","author":"Masnoon","year":"2017","journal-title":"BMC Geriatr"},{"key":"R77-20250604","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1111\/jgs.18372","article-title":"American Geriatrics Society 2023 updated AGS beers criteria for potentially inappropriate medication use in older adults.","volume":"71","author":"Panel","year":"2023","journal-title":"J Am Geriatr Soc"},{"key":"R78-20250604","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1097\/SLA.0000000000002765","article-title":"Association of preoperative anticholinergic medication exposure with postoperative healthcare resource use and outcomes: a population-based cohort study.","volume":"270","author":"McIsaac","year":"2019","journal-title":"Ann Surg"},{"key":"R79-20250604","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1213\/ANE.0000000000004641","article-title":"American Society for enhanced recovery and perioperative quality initiative joint consensus statement on postoperative delirium prevention.","volume":"130","author":"Hughes","year":"2020","journal-title":"Anesth Analg"},{"key":"R80-20250604","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1001\/jama.1994.03520190064036","article-title":"The relationship of postoperative delirium with psychoactive medications.","volume":"272","author":"Marcantonio","year":"1994","journal-title":"JAMA"},{"key":"R81-20250604","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0140-6736(17)31467-8","article-title":"Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.","volume":"390","author":"Avidan","year":"2017","journal-title":"Lancet"},{"key":"R82-20250604","first-page":"143","article-title":"The importance of correct patient positioning in theatres and implications of mal-positioning.","volume":"20","author":"Adedeji","year":"2010","journal-title":"J Perioper Pract"},{"key":"R83-20250604","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1213\/ANE.0000000000003841","article-title":"Best practices for postoperative brain health.","volume":"127","author":"Berger","year":"2018","journal-title":"Anesth Analg"},{"key":"R84-20250604","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/ANA.0b013e3182712fba","article-title":"BIS-guided anesthesia decreases postoperative delirium and cognitive decline.","volume":"25","author":"Chan","year":"2013","journal-title":"J Neurosurg Anesthesiol"},{"issue":"suppl_1","key":"R85-20250604","doi-asserted-by":"crossref","first-page":"ii98","DOI":"10.1093\/bja\/aet055","article-title":"Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction.","volume":"110","author":"Radtke","year":"2013","journal-title":"Br J Anaesth"},{"key":"R86-20250604","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1213\/ANE.0000000000006090","article-title":"Perioperative brain health in the older adult: a patient safety imperative.","volume":"135","author":"Vacas","year":"2022","journal-title":"Anesth Analg"},{"key":"R87-20250604","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.bja.2021.07.021","article-title":"Anaesthetic depth and delirium after major surgery: a randomised clinical trial.","volume":"127","author":"Evered","year":"2021","journal-title":"Br J Anaesth"},{"key":"R88-20250604","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/ACO.0000000000000793","article-title":"Anaesthetic considerations in nonagenarians and centenarians.","volume":"32","author":"Irwin","year":"2019","journal-title":"Curr Opin Anaesthesiol"},{"key":"R89-20250604","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1053\/j.jvca.2005.01.005","article-title":"Diastolic dysfunction in the older heart.","volume":"19","author":"Groban","year":"2005","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R90-20250604","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/lt.23723","article-title":"Cardiac arrest during adult liver transplantation: a single institution\u2019s experience with 1238 deceased donor transplants.","volume":"19","author":"Matsusaki","year":"2013","journal-title":"Liver Transplant"},{"key":"R91-20250604","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1213\/ANE.0000000000004734","article-title":"Intraoperative cardiac arrest during adult liver transplantation: incidence and risk factor analysis from 7 academic centers in the United States.","volume":"132","author":"Smith","year":"2020","journal-title":"Anesth Analg"},{"key":"R92-20250604","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/lt.24056","article-title":"Extracorporeal membrane oxygenation as a rescue device for postreperfusion cardiac arrest during liver transplantation.","volume":"21","author":"Tejani","year":"2015","journal-title":"Liver Transplant"},{"key":"R93-20250604","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1213\/ANE.0000000000000527","article-title":"The incidence and risk factors for perioperative cardiac arrest observed in the national anesthesia clinical outcomes registry.","volume":"120","author":"Nunnally","year":"2015","journal-title":"Anesth Analg"},{"key":"R94-20250604","doi-asserted-by":"crossref","first-page":"e104041","DOI":"10.1371\/journal.pone.0104041","article-title":"Intraoperative and anesthesia-related cardiac arrest and its mortality in older patients: a 15-year survey in a tertiary teaching hospital.","volume":"9","author":"Nunes","year":"2014","journal-title":"PLoS One"},{"key":"R95-20250604","doi-asserted-by":"crossref","first-page":"149","DOI":"10.14336\/AD.2014.0429","article-title":"Laparoscopic surgery in the elderly: a review of the literature.","volume":"6","author":"Bates","year":"2015","journal-title":"Aging Dis"},{"key":"R96-20250604","first-page":"CD012698","article-title":"Minimally invasive surgical techniques for kidney transplantation.","volume":"2017(7)","author":"Uwechue","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"R97-20250604","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.eururo.2017.02.020","article-title":"Minimally invasive, laparoscopic, and robotic-assisted techniques versus open techniques for kidney transplant recipients: a systematic review.","volume":"72","author":"Wagenaar","year":"2017","journal-title":"Eur Urol"},{"key":"R98-20250604","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/SLA.0b013e3182a15db4","article-title":"The evolution of liver transplantation during 3 decades: analysis of 5347 consecutive liver transplants at a single center.","volume":"258","author":"Agopian","year":"2013","journal-title":"Ann Surg"},{"key":"R99-20250604","doi-asserted-by":"crossref","first-page":"e1108","DOI":"10.1097\/SLA.0000000000003764","article-title":"Does postoperative cognitive decline result in new disability after surgery?","volume":"274","author":"Deiner","year":"2021","journal-title":"Ann Surg"},{"key":"R100-20250604","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/anae.12704","article-title":"A randomised controlled trial of ultrasound-guided transversus abdominis plane block for renal transplantation.","volume":"69","author":"Kuruba","year":"2014","journal-title":"Anaesthesia"},{"key":"R101-20250604","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/EJA.0000000000001193","article-title":"Transversus abdominis plane block versus quadratus lumborum block type 2 for analgesia in renal transplantation: a randomised trial.","volume":"37","author":"Kolacz","year":"2020","journal-title":"Eur J Anaesth"},{"key":"R102-20250604","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1136\/rapm-2022-103705","article-title":"Subcostal transversus abdominis plane block for postoperative analgesia in liver transplant recipients: a before-and-after study.","volume":"48","author":"Assefi","year":"2023","journal-title":"Reg Anesth Pain Med"},{"key":"R103-20250604","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/jamasurg.2023.0276","article-title":"Long-term outcomes following a comprehensive quality assurance and process improvement endeavor to minimize opioid use after kidney transplant.","volume":"158","author":"Carcella","year":"2023","journal-title":"Jama Surg"},{"key":"R104-20250604","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/ALN.0000000000003428","article-title":"Perioperative use of gabapentinoids for the management of postoperative acute pain.","volume":"133","author":"Verret","year":"2020","journal-title":"Anesthesiology"},{"key":"R105-20250604","first-page":"e938692-1","article-title":"Outcomes of kidney transplantation in older recipients.","volume":"28","author":"Hammad","year":"2023","journal-title":"Ann Transpl"},{"key":"R106-20250604","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1097\/TP.0000000000001710","article-title":"Incidence of and risk assessment for adverse cardiovascular outcomes after liver transplantation.","volume":"101","author":"Konerman","year":"2017","journal-title":"Transplantation"},{"key":"R107-20250604","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.hpb.2018.07.025","article-title":"Liver transplantation in elderly patients: a systematic review and first meta-analysis.","volume":"21","author":"G\u00f3mez Gavara","year":"2019","journal-title":"HPB (Oxford)"},{"key":"R108-20250604","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1681\/ASN.2018010064","article-title":"Incidence, risk factors, and sequelae of post-kidney transplant delirium.","volume":"29","author":"Haugen","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"R109-20250604","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1007\/s00268-018-4563-4","article-title":"Risk factors of postoperative delirium in the intensive care unit after liver transplantation.","volume":"42","author":"Lee","year":"2018","journal-title":"World J Surg"},{"key":"R110-20250604","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jss.2016.08.084","article-title":"Postoperative delirium is associated with increased intensive care unit and hospital length of stays after liver transplantation.","volume":"207","author":"Bhattacharya","year":"2017","journal-title":"J Surg Res"},{"key":"R111-20250604","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/MEG.0000000000001661","article-title":"A \u2018real-world\u2019 analysis of risk factors for post liver transplant delirium and the effect on length of stay.","volume":"32","author":"Tavabie","year":"2020","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R112-20250604","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s13304-020-00887-3","article-title":"Graft factors as determinants of postoperative delirium after liver transplantation.","volume":"72","author":"Patrono","year":"2020","journal-title":"Updates Surg"},{"key":"R113-20250604","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.bja.2020.10.037","article-title":"Improving perioperative brain health: an expert consensus review of key actions for the perioperative care team.","volume":"126","author":"Peden","year":"2021","journal-title":"Br J Anaesth"},{"key":"R114-20250604","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.transproceed.2019.11.015","article-title":"Effect of perioperative low-dose dexmedetomidine on postoperative delirium after living-donor liver transplantation: a randomized controlled trial.","volume":"52","author":"Lee","year":"2020","journal-title":"Transplant Proc"},{"key":"R115-20250604","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s40472-021-00321-6","article-title":"Immunosuppression considerations for older kidney transplant recipients.","volume":"8","author":"Cheungpasitporn","year":"2021","journal-title":"Curr Transplant Rep"},{"key":"R116-20250604","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1002\/bjs.10064","article-title":"Kidney and liver transplantation in the elderly.","volume":"103","author":"Sutherland","year":"2016","journal-title":"Br J Surg"},{"key":"R117-20250604","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1097\/TP.0000000000003547","article-title":"Immunosuppression regimen use and outcomes in older and younger adult kidney transplant recipients: a National Registry Analysis.","volume":"105","author":"Lentine","year":"2021","journal-title":"Transplantation"},{"key":"R118-20250604","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1097\/TP.0000000000001756","article-title":"Rapid discontinuation of prednisone in kidney transplant recipients.","volume":"101","author":"Serrano","year":"2017","journal-title":"Transplantation"},{"key":"R119-20250604","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1001\/jamasurg.2020.6929","article-title":"Early corticosteroid cessation vs long-term corticosteroid therapy in kidney transplant recipients.","volume":"156","author":"Woodle","year":"2021","journal-title":"JAMA Surg"},{"key":"R120-20250604","doi-asserted-by":"crossref","first-page":"101485","DOI":"10.1016\/j.trim.2021.101485","article-title":"Evaluation of rejection, infection, and malignancy outcomes in elderly liver transplant recipients receiving a similar level of immunosuppression compared to a younger group.","volume":"69","author":"Almalki","year":"2021","journal-title":"Transpl Immunol"},{"key":"R121-20250604","doi-asserted-by":"crossref","first-page":"100817","DOI":"10.1016\/j.trre.2023.100817","article-title":"Immunosuppression for older liver transplant recipients.","volume":"38","author":"Simone","year":"2024","journal-title":"Transplant Rev"},{"key":"R122-20250604","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1111\/jgs.13657","article-title":"Changes in frailty after kidney transplantation.","volume":"63","author":"McAdams-DeMarco","year":"2015","journal-title":"J Am Geriatr Soc"},{"key":"R123-20250604","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1111\/ajt.14675","article-title":"Physical frailty after liver transplantation.","volume":"18","author":"Lai","year":"2018","journal-title":"Am J Transplant"},{"key":"R124-20250604","doi-asserted-by":"crossref","first-page":"e14706","DOI":"10.1111\/ctr.14706","article-title":"The role of acute in-patient rehabilitation on short-term outcomes after liver transplantation: a systematic review of the literature and expert panel recommendations.","volume":"36","author":"Mina","year":"2022","journal-title":"Clin Transplant"},{"key":"R125-20250604","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/tri.13848","article-title":"The effects of exercise training in adult solid organ transplant recipients: a systematic review and meta-analysis.","volume":"34","author":"Janaudis-Ferreira","year":"2021","journal-title":"Transpl Int"},{"key":"R126-20250604","doi-asserted-by":"crossref","first-page":"611","DOI":"10.15403\/jgld-2829","article-title":"Quality of life after 10 years of liver transplantation.","volume":"29","author":"Domingos","year":"2020","journal-title":"J Gastrointestinal Liver Dis"},{"key":"R127-20250604","first-page":"808","article-title":"The effect of liver transplantation on patient-centred outcomes: a propensity-score matched analysis.","volume":"32","author":"McLean","year":"2019","journal-title":"Transpl Int"},{"key":"R128-20250604","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1007\/s00423-021-02183-z","article-title":"Health-related quality of life, workability, and return to work of patients after liver transplantation.","volume":"406","author":"Fazekas","year":"2021","journal-title":"Langenbecks Arch Surg"},{"key":"R129-20250604","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/tri.13388","article-title":"Simultaneous liver kidney transplantation.","volume":"32","author":"Singal","year":"2019","journal-title":"Transpl Int"},{"key":"R130-20250604","first-page":"870","article-title":"Simultaneous liver and kidney transplantation in elderly patients: outcomes and validation of a clinical risk score for patient selection.","volume":"15","author":"Croome","year":"2016","journal-title":"Ann Hepatol"},{"key":"R131-20250604","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1001\/jamasurg.2016.4952","article-title":"Enhanced recovery after surgery: a review.","volume":"152","author":"Ljungqvist","year":"2017","journal-title":"JAMA Surg"},{"key":"R132-20250604","doi-asserted-by":"crossref","first-page":"e14453","DOI":"10.1111\/ctr.14453","article-title":"Enhanced recovery after surgery programs improve short-term outcomes after liver transplantation: a systematic review and meta-analysis.","volume":"35","author":"Tinguely","year":"2021","journal-title":"Clin Transplant"},{"key":"R133-20250604","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1111\/ans.15461","article-title":"Development and implementation of an enhanced recovery after surgery protocol for renal transplantation.","volume":"89","author":"Dias","year":"2019","journal-title":"ANZ J Surg"},{"key":"R134-20250604","doi-asserted-by":"crossref","first-page":"e209265","DOI":"10.1001\/jamanetworkopen.2020.9265","article-title":"Association of geriatric comanagement and 90-day postoperative mortality among patients aged 75 years and older with cancer.","volume":"3","author":"Shahrokni","year":"2020","journal-title":"Jama Netw Open"},{"key":"R135-20250604","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jamda.2021.10.022","article-title":"Effectiveness of comanagement model: geriatric medicine and vascular surgery.","volume":"23","author":"Natesan","year":"2022","journal-title":"J Am Med Dir Assoc"},{"key":"R136-20250604","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1097\/BOT.0b013e3182a5a045","article-title":"Orthogeriatric care models and outcomes in hip fracture patients.","volume":"28","author":"Grigoryan","year":"2014","journal-title":"J Orthop Trauma"}],"container-title":["Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/TP.0000000000005000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T18:02:16Z","timestamp":1749060136000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/TP.0000000000005000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":136,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/tp.0000000000005000","relation":{},"ISSN":["0041-1337","1534-6080"],"issn-type":[{"value":"0041-1337","type":"print"},{"value":"1534-6080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,1]]}}}