{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:05:15Z","timestamp":1792483515485,"version":"4.5.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,5,27]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction.<\/jats:title>\n                    <jats:p>There is growing awareness, yet scant prospective evidence that pretransplant (TX) psychosocial factors may predict post-TX outcome. We examined which pre-TX psychosocial factors predict post-TX nonadherence with immunosuppression (NA) and clinical outcomes in heart, liver, and lung TX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology.<\/jats:title>\n                    <jats:p>We prospectively followed 141 patients (28 heart, 61 liver, and 52 lung) from pre-TX until 1 year post-TX. Multivariable analyses determined which pre-TX factors (i.e., anxiety, depression, personality traits, social support, adherence with medication, and smoking status) predict poor post-TX outcome (i.e., NA, late acute rejection, graft loss, and resource utilization), controlling for medical predictors of poor outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Pre-TX self-reported medication nonadherence (odds ratio [OR]=7.9), lower received social support (OR=0.9), a higher education (OR=2.7), and lower \u201cconscientiousness\u201d (OR=0.8) were independent predictors of post-TX NA. Not living in a stable relationship predicted graft loss (OR=4.9). Pre-TX medication NA was the only predictor for presence of late acute rejection (OR=4.4). No other pre-TX predictors for poor outcome could be found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>This is the first prospective study demonstrating that selected pre-TX psychosocial factors predict post-TX NA and poor clinical outcome, implying that pre-TX screening should include this set of factors in addition to traditional medical criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/tp.0b013e3181a440ae","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T17:18:37Z","timestamp":1242926317000},"page":"1497-1504","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":244,"title":["Pretransplant Predictors of Posttransplant Adherence and Clinical Outcome"],"prefix":"10.1097","volume":"87","author":[{"given":"Fabienne","family":"Dobbels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Vanhaecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieven","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Nevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Verleden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Pirenne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"De Geest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20260130","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/01.TP.0000091171.82384.33","article-title":"A prognostic model for predicting waiting-list mortality for a total national cohort of adult heart-transplant candidates","volume":"76","author":"Smits","year":"2003","journal-title":"Transplantation"},{"key":"R2-11-20260130","first-page":"635","article-title":"Patient selection criteria for liver transplantation","volume":"58","author":"Yu","year":"2003","journal-title":"Minerva Chir"},{"key":"R3-11-20260130","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1052-3359(03)00057-7","article-title":"Lung transplantation. Recipient selection","volume":"13","author":"Yu","year":"2003","journal-title":"Chest Surg Clin N Am"},{"key":"R4-11-20260130","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/01.TP.0000101009.91516.FC","article-title":"Predicting outcome after liver transplantation: Utility of the model for end-stage liver disease and a newly derived discrimination function","volume":"77","author":"Desai","year":"2004","journal-title":"Transplantation"},{"key":"R5-11-20260130","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1089-3261(03)00052-7","article-title":"Organ allocation: Model for end-stage liver disease, Child-Turcotte-Pugh, Mayo risk score, or something else","volume":"7","author":"Botero","year":"2003","journal-title":"Clin Liver Dis"},{"key":"R6-11-20260130","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1053\/jlts.2003.50089","article-title":"A model to predict survival at one month, one year, and five years after liver transplantation based on pretransplant clinical characteristics","volume":"9","author":"Thuluvath","year":"2003","journal-title":"Liver Transpl"},{"key":"R7-11-20260130","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1097\/01.TP.0000092005.95047.E9","article-title":"The heart-allocation simulation model: A tool for comparison of transplantation allocation policies","volume":"76","author":"van den Hout","year":"2003","journal-title":"Transplantation"},{"key":"R8-11-20260130","first-page":"245","article-title":"Heart transplantation. An update and review","volume":"51","author":"Johnson","year":"2003","journal-title":"Minerva Cardioangiol"},{"key":"R9-11-20260130","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S1053-2498(02)00428-X","article-title":"Recipient selection in cardiac transplantation: Contraindications and risk factors for mortality","volume":"21","author":"Cimato","year":"2002","journal-title":"J Heart Lung Transplant"},{"key":"R10-11-20260130","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/heart.87.2.177","article-title":"Cardiac transplantation","volume":"87","author":"Deng","year":"2002","journal-title":"Heart"},{"key":"R11-11-20260130","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1183\/09031936.03.00039003","article-title":"Indications, patient selection and timing of referral for lung transplantation","volume":"22","author":"Glanville","year":"2003","journal-title":"Eur Respir J"},{"key":"R12-11-20260130","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00044067-199905000-00009","article-title":"The current status of lung transplantation: A nursing perspective","volume":"10","author":"Ochoa","year":"1999","journal-title":"AACN Clin Issues"},{"key":"R13-11-20260130","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1097\/00007890-200105150-00001","article-title":"Guidelines for the referral and management of patients eligible for solid organ transplantation","volume":"71","author":"Steinman","year":"2001","journal-title":"Transplantation"},{"key":"R14-11-20260130","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1097\/00007890-199810150-00033","article-title":"International guidelines for the selection of lung transplant candidates. The International Society for Heart and Lung Transplantation, the American Thoracic Society, the American Society of Transplant Physicians, the European Respiratory Society","volume":"66","author":"Maurer","year":"1998","journal-title":"Transplantation"},{"key":"R15-11-20260130","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/(SICI)1098-240X(199808)21:4<327::AID-NUR5>3.0.CO;2-H","article-title":"Rationing organs using psychosocial and lifestyle criteria","volume":"21","author":"Corley","year":"1998","journal-title":"Res Nurs Health"},{"key":"R16-11-20260130","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0033-3182(93)71865-4","article-title":"Psychosocial evaluation of organ transplant candidates. A comparative survey of process, criteria, and outcomes in heart, liver, and kidney transplantation","volume":"34","author":"Levenson","year":"1993","journal-title":"Psychosomatics"},{"key":"R17-11-20260130","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0033-3182(95)71662-0","article-title":"Psychosocial assessment of organ transplant candidates. Current status of methodological and philosophical issues","volume":"36","author":"Olbrisch","year":"1995","journal-title":"Psychosomatics"},{"key":"R18-11-20260130","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/152692480101100208","article-title":"Psychosocial and behavioral selection criteria for solid organ transplantation","volume":"11","author":"Dobbels","year":"2001","journal-title":"Prog Transplant"},{"key":"R19-11-20260130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1191\/1479972306cd082ra","article-title":"To transplant or not? The importance of psychosocial and behavioral factors before lung transplantation","volume":"3","author":"Dobbels","year":"2006","journal-title":"Chron Respir Dis"},{"key":"R20-11-20260130","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00006199-200205000-00002","article-title":"Racial and socioeconomic differences in risk factors for cardiovascular disease among Southern rural women","volume":"51","author":"Appel","year":"2002","journal-title":"Nurs Res"},{"key":"R21-11-20260130","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"R24-11-20260130","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1089\/apc.2004.18.644","article-title":"Prevalence and correlates of nonadherence to antiretroviral therapy in a population of HIV patients using medication event monitoring system","volume":"18","author":"Deschamps","year":"2004","journal-title":"AIDS Patient Care STDS"},{"key":"R26-11-20260130","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chron Dis"},{"key":"R27-11-20260130","first-page":"854","article-title":"Late acute rejection and subclinical noncompliance with cyclosporine therapy in heart transplant recipients","volume":"17","author":"De Geest","year":"1998","journal-title":"J Heart Lung Transplant"},{"key":"R28-11-20260130","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/019394599601800509","article-title":"Measuring transplant patients\u2019 compliance with immunosuppressive therapy","volume":"18","author":"De Geest","year":"1996","journal-title":"West J Nurs Res"},{"key":"R29-11-20260130","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1097\/00007890-199812270-00026","article-title":"Compliance and noncompliance in patients with a functioning renal transplant: A multicenter study","volume":"66","author":"Greenstein","year":"1998","journal-title":"Transplantation"},{"key":"R30-11-20260130","first-page":"713","article-title":"A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts. International Society for Heart and Lung Transplantation","volume":"12","author":"Cooper","year":"1993","journal-title":"J Heart Lung Transplant"},{"key":"R31-11-20260130","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/hep.510250328","article-title":"Banff schema for grading liver allograft rejection: An international consensus document.","volume":"25","year":"1997","journal-title":"Hepatology"},{"key":"R32-11-20260130","first-page":"587","article-title":"A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation","volume":"9","author":"Billingham","year":"1990","journal-title":"J Heart Transplant"},{"key":"R33-11-20260130","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1161\/01.CIR.0000149745.83186.89","article-title":"Drug therapy in the heart transplant recipient. I. Cardiac rejection and immunosuppressive drugs","volume":"110","author":"Lindenfeld","year":"2004","journal-title":"Circulation"},{"key":"R34-11-20260130","first-page":"437","article-title":"Noncompliance in organ transplantation: Is it worth worrying about?","volume":"68","author":"Desmyttere","year":"2005","journal-title":"Acta Gastroenterol Belg"},{"key":"R35-11-20260130","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1046\/j.1399-0012.2003.00139.x","article-title":"The incidence and significance of late cellular rejection (>1000 days) after liver transplantation","volume":"18","author":"Florman","year":"2004","journal-title":"Clin Transplant"},{"key":"R36-11-20260130","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/01.hco.0000153950.49813.d2","article-title":"Is biopsy-proven cellular rejection an important clinical consideration in heart transplantation?","volume":"20","author":"Kirklin","year":"2005","journal-title":"Curr Opin Cardiol"},{"key":"R37-11-20260130","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1053\/j.semtcvs.2004.09.011","article-title":"Bronchiolitis obliterans syndrome: Pathogenesis and management","volume":"16","author":"Hachem","year":"2004","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"R41-11-20260130","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/00007890-200009150-00001","article-title":"Solid organ transplantation: Are there predictors for posttransplant noncompliance? A literature overview","volume":"70","author":"Bunzel","year":"2000","journal-title":"Transplantation"},{"key":"R42-11-20260130","doi-asserted-by":"crossref","first-page":"53","DOI":"10.7182\/prtr.1.6.2.x11r325882657x21","article-title":"Relationship between pretransplant noncompliance and posttransplant outcomes in renal transplant recipients","volume":"6","author":"Douglas","year":"1996","journal-title":"J Transplant Coord"},{"key":"R43-11-20260130","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1037\/0278-6133.23.2.207","article-title":"Social support and patient adherence to medical treatment: A meta-analysis","volume":"23","author":"DiMatteo","year":"2004","journal-title":"Health Psychol"},{"key":"R44-11-20260130","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/01.mlr.0000114908.90348.f9","article-title":"Variations in patients\u2019 adherence to medical recommendations. A quantitative review of 50 years of research","volume":"42","author":"DiMatteo","year":"2004","journal-title":"Med Care"},{"key":"R45-11-20260130","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1532-5415.1999.tb04575.x","article-title":"Medication adherence in rheumatoid arthritis patients: Older is wiser","volume":"47","author":"Park","year":"1999","journal-title":"J Am Geriatr Soc"},{"key":"R46-11-20260130","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF01857875","article-title":"Personality and patient adherence: Correlates of the five-factor model in renal dialysis","volume":"18","author":"Christensen","year":"1995","journal-title":"J Behav Med"},{"key":"R47-11-20260130","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF02883424","article-title":"Health beliefs, personality and adherence in hemodialysis patients: An interactional perspective","volume":"19","author":"Wiebe","year":"1997","journal-title":"Ann Behav Med"},{"key":"R48-11-20260130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1207\/s15324796abm2702_6","article-title":"Psychological and cognitive function: Predictors of adherence with cholesterol lowering treatment","volume":"27","author":"Stilley","year":"2004","journal-title":"Ann Behav Med"},{"key":"R49-11-20260130","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1055\/s-2007-1016466","article-title":"Heart transplantation: Are there psychosocial predictors for clinical success of surgery?","volume":"42","author":"Bunzel","year":"1994","journal-title":"Thorac Cardiovasc Surg"},{"key":"R50-11-20260130","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0277-9536(00)00065-4","article-title":"From social integration to health: Durkheim in the new millennium","volume":"51","author":"Berkman","year":"2000","journal-title":"Soc Sci Med"},{"key":"R51-11-20260130","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.healun.2003.09.016","article-title":"Effect of late medication non-compliance on outcome after heart transplantation: A 5-year follow-up","volume":"23","author":"Dobbels","year":"2004","journal-title":"J Heart Lung Transplant"},{"key":"R52-11-20260130","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1053-2498(98)00044-8","article-title":"Early post-transplant medical compliance and mental health predict physical morbidity and mortality one to three years after heart transplantation","volume":"18","author":"Dew","year":"1999","journal-title":"J Heart Lung Transplant"},{"key":"R53-11-20260130","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1046\/j.1523-1755.2001.00961.x","article-title":"The natural history of azathioprine compliance after renal transplantation","volume":"60","author":"Nevins","year":"2001","journal-title":"Kidney Int"},{"key":"R54-11-20260130","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1111\/j.1600-6143.2004.00537.x","article-title":"Prospective study on late consequences of subclinical non-compliance with immunosuppressive therapy in renal transplant patients","volume":"4","author":"Vlaminck","year":"2004","journal-title":"Am J Transplant"},{"key":"R55-11-20260130","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1097\/01.TP.0000158430.06507.87","article-title":"Prevalence and correlates of self-reported pre-transplant non-adherence with medication in heart, liver and lung transplant candidates","volume":"79","author":"Dobbels","year":"2005","journal-title":"Transplantation"},{"key":"R56-11-20260130","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/01.tp.0000258599.65257.a6","article-title":"Rates and risk factors for nonadherence to the medical regimen after solid organ transplantation","volume":"83","author":"Dew","year":"2007","journal-title":"Transplantation"}],"container-title":["Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00007890-200905270-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:01:22Z","timestamp":1769778082000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00007890-200905270-00011"}},"subtitle":["An Evidence Base for Pretransplant Psychosocial Screening"],"short-title":[],"issued":{"date-parts":[[2009,5,27]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/tp.0b013e3181a440ae","relation":{},"ISSN":["0041-1337"],"issn-type":[{"value":"0041-1337","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5,27]]}}}