{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T06:33:08Z","timestamp":1778308388131,"version":"3.51.4"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,5,27]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Method.<\/jats:title>\n                    <jats:p>Combined liver kidney transplant (CLKT) is a recognized treatment option for end-stage renal disease due to primary hyperoxaluria (PH-I) and cystic disorders, yet there is only limited data on posttransplant renal function recovery. The objective of this study was to assess postoperative renal function of children with PH-I (group A) undergoing CLKT and to compare this with a cohort of children (group B) who received CLKT for other indications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      Twenty-three patients underwent CLKT between 1994 and 2008 (group A: 9 patients; median age 8.6 [1.6\u201316.7] years; group B: 14 patients; median age 8.5 [1.9\u201314.6] years). The median follow-up was 88 (14\u2013112) and 22 (4\u2013109) months. Both groups were transplanted with comparable organs. Eight (8\/9) and six (6\/14) patients received preoperative renal support in each group, respectively, whereas an equal proportion of them required early postoperative renal support (4\/8; 50% and 3\/6; 50%, respectively). Glomerular function was significantly different between groups until first year posttransplant (median estimated glomerular filtration rate: groups A vs. B; at pretransplant, 3 mo, 6 mo, and 12 mo posttransplant, respectively; 11.06 vs. 12.61 [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.4], 40.78 vs. 75.83 [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.03], 42.59 vs. 80.56 [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.04] and 53.57 vs. 76.75 [\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.005]). Overall 1-year survival is 89% versus 90% and 5-year survival is 89% versus 62%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary.<\/jats:title>\n                    <jats:p>Children with PH-I receiving CLKT seem to have delayed recovery of renal function compared with polycystic disease, possibly due to mobilization of systemic oxalate. Consideration should be given to earlier or preemptive transplantation for children with PH-I.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/tp.0b013e3181a4e710","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T17:18:37Z","timestamp":1242926317000},"page":"1584-1589","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Renal Function Recovery in Children Undergoing Combined Liver Kidney Transplants"],"prefix":"10.1097","volume":"87","author":[{"given":"M Thamara P.R.","family":"Perera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"McKiernan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David V.","family":"Milford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre A.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darius F.","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-23-20260130","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/BF01957682","article-title":"Primary hyperoxaluria type I","volume":"149","author":"Latta","year":"1990","journal-title":"Eur J Pediatr"},{"key":"R2-23-20260130","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/ndt\/10.supp8.53","article-title":"Selection of transplantation procedures and perioperative management in primary hyperoxaluria type 1","volume":"10","author":"Latta","year":"1995","journal-title":"Nephrol Dial Transplant"},{"key":"R3-23-20260130","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/ndt\/16.2.348","article-title":"Combined liver-kidney transplantation for primary hyperoxaluria type 1 in young children","volume":"16","author":"Ellis","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"R4-23-20260130","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1046\/j.1399-3046.2003.00132.x","article-title":"The effect of long-term calcineurin inhibitor therapy on renal function in children after liver transplantation","volume":"8","author":"Arora-Gupta","year":"2004","journal-title":"Pediatr Transplant"},{"key":"R5-23-20260130","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0022-3476(85)80697-1","article-title":"A simple estimate of glomerular filtration rate in adolescent boys","volume":"106","author":"Schwartz","year":"1985","journal-title":"J Pediatr"},{"key":"R6-23-20260130","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0022-3476(84)80479-5","article-title":"A simple estimate of glomerular filtration rate in full-term infants during the first year of life","volume":"104","author":"Schwartz","year":"1984","journal-title":"J Pediatr"},{"key":"R7-23-20260130","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/00007890-200108150-00012","article-title":"Primary herperoxaluria type I: Improved outcome with timely liver transplantation: A single centre report of 36 children","volume":"72","author":"Shaprio","year":"2001","journal-title":"Transplantation"},{"key":"R8-23-20260130","first-page":"1557","article-title":"Liver and kidney transplantation in the treatment of primary hyperoxaluria","volume":"23","author":"Jamieson","year":"1991","journal-title":"Transplant Proc"},{"key":"R10-23-20260130","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/ndt\/10.supp8.42","article-title":"Transplantation for primary hyperoxaluria in the USA","volume":"10","author":"Scheinman","year":"1995","journal-title":"Nephrol Dial Transplant"},{"key":"R11-23-20260130","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1159\/000086359","article-title":"A 20-Year Experience of Combined Liver\/Kidney Transplantation for Primary Hyperoxaluria (PH-I): The European PH-I Transplant Registry Experience 1984\u20132004","volume":"25","author":"Jamieson","year":"2005","journal-title":"Am J Nephrol"},{"key":"R12-23-20260130","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/ndt\/10.supp8.33","article-title":"The European Primary Hyperoxaluria Type 1 Transplant Registry report on the results of combined liver\/kidney transplantation for primary hyperoxaluria 1984\u20131994. 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