{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:16:40Z","timestamp":1786119400612,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,27]]},"DOI":"10.1097\/tp.0b013e3181c425fd","type":"journal-article","created":{"date-parts":[[2010,1,16]],"date-time":"2010-01-16T02:55:14Z","timestamp":1263610514000},"page":"161-168","source":"Crossref","is-referenced-by-count":21,"title":["rHuEPo Reduces Ischemia-Reperfusion Injury and Improves Survival After Transplantation of Fatty Livers in Rats"],"prefix":"10.1097","volume":"89","author":[{"given":"Maximilian","family":"Schmeding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Rademacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Boas-Knoop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Roecken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Lendeckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Neuhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf P.","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210129","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/lt.20304","article-title":"Expanded criteria donor grafts for deceased donor liver transplantation under the MELD system: A decision analysis.","volume":"10","author":"Amin","year":"2004","journal-title":"Liver Transpl"},{"key":"R2-6-20210129","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1600-6143.2004.00703.x","article-title":"The survival benefit of liver transplantation.","volume":"5","author":"Merion","year":"2005","journal-title":"Am J Transplant"},{"key":"R3-6-20210129","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1600-6143.2007.02086.x","article-title":"The survival benefit of deceased donor liver transplantation as a function of candidate disease severity and donor quality.","volume":"8","author":"Schaubel","year":"2008","journal-title":"Am J Transplant"},{"key":"R4-6-20210129","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/01.TP.0000071846.35825.B1","article-title":"Beneficial effect of pentoxifylline on microvesicular steatotic livers submitted to a prolonged cold ischemia.","volume":"76","author":"Arnault","year":"2003","journal-title":"Transplantation"},{"key":"R5-6-20210129","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1111\/j.1600-6143.2004.00546.x","article-title":"Fatty acid synthase blockade protects steatotic livers from warm ischemia reperfusion injury and transplantation.","volume":"4","author":"Chavin","year":"2004","journal-title":"Am J Transplant"},{"key":"R6-6-20210129","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/01.TP.0000065299.29900.17","article-title":"Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat.","volume":"76","author":"Lehmann","year":"2003","journal-title":"Transplantation"},{"key":"R7-6-20210129","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jhep.2005.07.032","article-title":"Mouse livers with macrosteatosis are more susceptible to normothermic ischemic injury than those with microsteatosis.","volume":"44","author":"Selzner","year":"2006","journal-title":"J Hepatol"},{"key":"R8-6-20210129","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0168-8278(03)00147-8","article-title":"Ischemic preconditioning protects the steatotic mouse liver against reperfusion injury: An ATP dependent mechanism.","volume":"39","author":"Selzner","year":"2003","journal-title":"J Hepatol"},{"key":"R9-6-20210129","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/01.TP.0000071205.52835.A4","article-title":"Use of steatotic graft in living-donor liver transplantation.","volume":"76","author":"Soejima","year":"2003","journal-title":"Transplantation"},{"key":"R10-6-20210129","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2170\/physiolsci.RP004806","article-title":"Erythropoietin changes contractility, cAMP, and nitrite levels of isolated rat hearts.","volume":"56","author":"Kaygisiz","year":"2006","journal-title":"J Physiol Sci"},{"key":"R11-6-20210129","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1172\/JCI18200","article-title":"A novel protective effect of erythropoietin in the infarcted heart.","volume":"112","author":"Parsa","year":"2003","journal-title":"J Clin Invest"},{"key":"R12-6-20210129","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/sj.jcbfm.9600370","article-title":"Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives.","volume":"27","author":"Villa","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"R13-6-20210129","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/01.shk.00001276869.21260.9d","article-title":"Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia.","volume":"22","author":"Abdelrahman","year":"2004","journal-title":"Shock"},{"key":"R14-6-20210129","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1440-1797.2006.00585.x","article-title":"Novel renoprotective actions of erythropoietin: New uses for an old hormone.","volume":"11","author":"Johnson","year":"2006","journal-title":"Nephrology (Carlton)"},{"key":"R15-6-20210129","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/j.1432-2277.2006.00366.x","article-title":"Recombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat.","volume":"19","author":"Sepodes","year":"2006","journal-title":"Transpl Int"},{"key":"R16-6-20210129","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000101009","article-title":"Erythropoietin reduces ischemia-reperfusion injury in the rat liver.","volume":"39","author":"Schmeding","year":"2007","journal-title":"Eur Surg Res"},{"key":"R17-6-20210129","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10495-007-0155-8","article-title":"Recombinant human erythropoietin attenuates hepatic injury induced by ischemia\/reperfusion in an isolated mouse liver model.","volume":"13","author":"Hochhauser","year":"2008","journal-title":"Apoptosis"},{"key":"R18-6-20210129","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1432-2277.2009.00861.x","article-title":"Erythropoietin reduces ischemia-reperfusion injury after liver transplantation in rats.","volume":"22","author":"Schmeding","year":"2009","journal-title":"Transpl Int"},{"key":"R19-6-20210129","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/j.1440-1746.2007.05265.x","article-title":"Erythropoietin promotes hepatic regeneration after extended liver resection in rats.","volume":"23","author":"Schmeding","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"R20-6-20210129","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/ejvs.1999.0889","article-title":"A possible side-effect of human erythropoietin therapy: Thrombosis of peripheral arterial reconstruction.","volume":"18","author":"Mingoli","year":"1999","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"R21-6-20210129","first-page":"179","article-title":"Erythropoietin alert: Risks of high hematocrit hemodialysis.","volume":"34","author":"Shinaberger","year":"1988","journal-title":"ASAIO Trans"},{"key":"R22-6-20210129","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1254\/jphs.FP0050966","article-title":"Effects of erythropoietin on cardiac remodeling after myocardial infarction.","volume":"101","author":"Nishiya","year":"2006","journal-title":"J Pharmacol Sci"},{"key":"R23-6-20210129","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1073\/pnas.0630444100","article-title":"Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling.","volume":"100","author":"Calvillo","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"R24-6-20210129","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1111\/j.1600-6143.2005.00877.x","article-title":"The influence of phosphatidylinositol 3-kinase\/Akt pathway on the ischemic injury during rat liver graft preservation.","volume":"5","author":"Li","year":"2005","journal-title":"Am J Transplant"},{"key":"R25-6-20210129","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.jhep.2005.01.030","article-title":"JNK mediates hepatic ischemia reperfusion injury.","volume":"42","author":"Uehara","year":"2005","journal-title":"J Hepatol"},{"issue":"2 suppl 1","key":"R26-6-20210129","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1002\/hep.21062","article-title":"Apoptosis and necrosis in the liver: A tale of two deaths?","volume":"43","author":"Malhi","year":"2006","journal-title":"Hepatology"},{"key":"R27-6-20210129","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1203\/01.PDR.0000163616.89767.69","article-title":"Erythropoietin improves functional and histological outcome in neonatal stroke.","volume":"58","author":"Chang","year":"2005","journal-title":"Pediatr Res"},{"key":"R28-6-20210129","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1073\/pnas.0812708106","article-title":"Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection.","volume":"106","author":"Gunnarson","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"R29-6-20210129","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1161\/STROKEAHA.107.483008","article-title":"Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia\/ischemia in rats.","volume":"38","author":"Iwai","year":"2007","journal-title":"Stroke"},{"key":"R30-6-20210129","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/hep.510260619","article-title":"Interleukin-6 protects liver against warm ischemia\/reperfusion injury and promotes hepatocyte proliferation in the rodent.","volume":"26","author":"Camargo","year":"1997","journal-title":"Hepatology"},{"key":"R31-6-20210129","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1053\/jhep.2000.16604","article-title":"Hyperstimulation with interleukin 6 inhibits cell cycle progression after hepatectomy in mice.","volume":"32","author":"Wustefeld","year":"2000","journal-title":"Hepatology"},{"key":"R32-6-20210129","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.resuscitation.2007.10.003","article-title":"Early high-dose erythropoietin therapy and hypothermia after out-of-hospital cardiac arrest: A matched control study.","volume":"76","author":"Cariou","year":"2008","journal-title":"Resuscitation"},{"key":"R33-6-20210129","doi-asserted-by":"crossref","first-page":"14907","DOI":"10.1073\/pnas.0406491101","article-title":"Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor.","volume":"101","author":"Brines","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"R34-6-20210129","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/15216540410001703956","article-title":"New insights into the regulation of erythroid cells.","volume":"56","author":"Ingley","year":"2004","journal-title":"IUBMB Life"},{"key":"R35-6-20210129","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00395-004-0508-1","article-title":"Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways.","volume":"100","author":"Rafiee","year":"2005","journal-title":"Basic Res Cardiol"},{"key":"R36-6-20210129","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1001\/jama.293.1.90","article-title":"New avenues of exploration for erythropoietin.","volume":"293","author":"Maiese","year":"2005","journal-title":"JAMA"},{"key":"R37-6-20210129","doi-asserted-by":"crossref","first-page":"10291","DOI":"10.1523\/JNEUROSCI.22-23-10291.2002","article-title":"Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: Evidence from an in vitro model.","volume":"22","author":"Ruscher","year":"2002","journal-title":"J Neurosci"},{"key":"R38-6-20210129","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0168-8278(00)80364-5","article-title":"Atrial natriuretic peptide reduces expression of TNF-alpha mRNA during reperfusion of the rat liver upon decreased activation of NF-kappaB and AP-1.","volume":"33","author":"Kiemer","year":"2000","journal-title":"J Hepatol"},{"key":"R39-6-20210129","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/01.sla.0000110321.64275.95","article-title":"Glutathione protects the rat liver against reperfusion injury after prolonged warm ischemia.","volume":"239","author":"Schauer","year":"2004","journal-title":"Ann Surg"},{"key":"R40-6-20210129","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/hep.21929","article-title":"Matrix metalloproteinase inhibition protects rat livers from prolonged cold ischemia-warm reperfusion injury.","volume":"47","author":"Defamie","year":"2008","journal-title":"Hepatology"},{"key":"R41-6-20210129","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.20480","article-title":"Biliverdin therapy protects rat livers from ischemia and reperfusion injury.","volume":"40","author":"Fondevila","year":"2004","journal-title":"Hepatology"},{"key":"R42-6-20210129","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/hep.21922","article-title":"Metalloproteinase-9 deficiency protects against hepatic ischemia\/reperfusion injury.","volume":"47","author":"Hamada","year":"2008","journal-title":"Hepatology"},{"key":"R43-6-20210129","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1097\/01.TP.0000141095.06273.10","article-title":"Caspase 3 inhibition improves survival and reduces early graft injury after ischemia and reperfusion in rat liver transplantation.","volume":"78","author":"Mueller","year":"2004","journal-title":"Transplantation"},{"key":"R44-6-20210129","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s10495-008-0234-5","article-title":"Blockade of the Fas\/Fas ligand interaction suppresses hepatocyte apoptosis in ischemia-reperfusion rat liver.","volume":"13","author":"Nakajima","year":"2008","journal-title":"Apoptosis"}],"container-title":["Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/TP.0b013e3181c425fd","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:12:38Z","timestamp":1786039958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00007890-201001270-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,27]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/tp.0b013e3181c425fd","relation":{},"ISSN":["0041-1337"],"issn-type":[{"value":"0041-1337","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1,27]]}}}