{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:45:05Z","timestamp":1791308705514,"version":"4.3.1"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7,27]]},"DOI":"10.1097\/tp.0b013e3181e2a932","type":"journal-article","created":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T07:05:43Z","timestamp":1275548743000},"page":"189-197","source":"Crossref","is-referenced-by-count":69,"title":["Validation of Noninvasive Diagnosis of BK Virus Nephropathy and Identification of Prognostic Biomarkers"],"prefix":"10.1097","volume":"90","author":[{"given":"Darshana","family":"Dadhania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Snopkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchuang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thangamani","family":"Muthukumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heejung","family":"Bang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya","family":"Seshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"August","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Kapur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikkam","family":"Suthanthiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20210129","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1097\/01.TP.0000156165.83160.09","article-title":"Polyomavirus-associated nephropathy in renal transplantation: Interdisciplinary analyses and recommendations.","volume":"79","author":"Hirsch","year":"2005","journal-title":"Transplantation"},{"key":"R2-13-20210129","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/TP.0b013e318197c17d","article-title":"The decade of polyomavirus BK-associated nephropathy: State of affairs.","volume":"87","author":"Ramos","year":"2009","journal-title":"Transplantation"},{"key":"R3-13-20210129","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00007890-199901150-00018","article-title":"Human polyoma virus-associated interstitial nephritis in the allograft kidney.","volume":"67","author":"Randhawa","year":"1999","journal-title":"Transplantation"},{"key":"R4-13-20210129","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1681\/ASN.V1051080","article-title":"Polyomavirus infection of renal allograft recipients: From latent infection to manifest disease.","volume":"10","author":"Nickeleit","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"R5-13-20210129","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1097\/01.ASN.0000023435.07320.81","article-title":"Clinical course of polyoma virus nephropathy in 67 renal transplant patients.","volume":"13","author":"Ramos","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R6-13-20210129","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0272-6386(95)90608-8","article-title":"BK virus infection in a kidney allograft diagnosed by needle biopsy.","volume":"26","author":"Purighalla","year":"1995","journal-title":"Am J Kidney Dis"},{"key":"R7-13-20210129","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/sj.ki.5000040","article-title":"BK virus nephritis after renal transplantation.","volume":"69","author":"Hariharan","year":"2006","journal-title":"Kidney Int"},{"key":"R8-13-20210129","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2215\/CJN.02021205","article-title":"Histologic versus molecular diagnosis of BK polyomavirus-associated nephropathy: A shifting paradigm?","volume":"1","author":"Drachenberg","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"R9-13-20210129","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJM200005043421802","article-title":"Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy.","volume":"342","author":"Nickeleit","year":"2000","journal-title":"N Engl J Med"},{"key":"R10-13-20210129","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1097\/00007890-200210150-00016","article-title":"Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine.","volume":"74","author":"Ding","year":"2002","journal-title":"Transplantation"},{"key":"R11-13-20210129","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1128\/JCM.42.3.1176-1180.2004","article-title":"Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients.","volume":"42","author":"Randhawa","year":"2004","journal-title":"J Clin Microbiol"},{"key":"R12-13-20210129","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/01.tp.0000275205.41078.51","article-title":"Polyomavirus polymerase chain reaction as a surrogate marker of polyomavirus-associated nephropathy.","volume":"84","author":"Viscount","year":"2007","journal-title":"Transplantation"},{"key":"R13-13-20210129","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1440-1797.2009.01118.x","article-title":"Diagnostic accuracy of blood qualitative nucleic acid testing for polyomavirus-associated nephropathy in kidney recipients.","volume":"14","author":"Cross","year":"2009","journal-title":"Nephrology (Carlton)"},{"key":"R14-13-20210129","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJMoa020439","article-title":"Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients.","volume":"347","author":"Hirsch","year":"2002","journal-title":"N Engl J Med"},{"key":"R15-13-20210129","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1046\/j.1600-6143.2004.00603.x","article-title":"Histological patterns of polyomavirus nephropathy: Correlation with graft outcome and viral load.","volume":"4","author":"Drachenberg","year":"2004","journal-title":"Am J Transplant"},{"key":"R16-13-20210129","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/01.tp.0000226176.87700.a4","article-title":"Clinical utility of histological features of polyomavirus allograft nephropathy.","volume":"82","author":"Gaber","year":"2006","journal-title":"Transplantation"},{"issue":"5","key":"R17-13-20210129","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/j.1600-6143.2006.01296.x","article-title":"Kidney transplant function and histological clearance of virus following diagnosis of polyomavirus-associated nephropathy (PVAN).","volume":"6","author":"Wadei","year":"2006","journal-title":"Am J Transplant"},{"key":"R18-13-20210129","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/TP.0b013e31817eef7b","article-title":"Noninvasive prediction of organ graft rejection and outcome using gene expression patterns.","volume":"86","author":"Anglicheau","year":"2008","journal-title":"Transplantation"},{"key":"R19-13-20210129","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/TP.0b013e31817c6447","article-title":"Epidemiology of BK virus in renal allograft recipients: Independent risk factors for BK virus replication.","volume":"86","author":"Dadhania","year":"2008","journal-title":"Transplantation"},{"key":"R20-13-20210129","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1046\/j.1523-1755.1999.00299.x","article-title":"The Banff 97 working classification of renal allograft pathology.","volume":"55","author":"Racusen","year":"1999","journal-title":"Kidney Int"},{"key":"R21-13-20210129","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1111\/j.1600-6143.2004.00585.x","article-title":"Banff 2003 meeting report: New diagnostic insights and standards.","volume":"4","author":"Racusen","year":"2004","journal-title":"Am J Transplant"},{"key":"R22-13-20210129","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jviromet.2009.09.010","article-title":"A real-time PCR assay for quantification of canine adenoviral vectors.","volume":"163","author":"Segura","year":"2010","journal-title":"J Virol Methods"},{"key":"R23-13-20210129","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1056\/NEJMoa051907","article-title":"Messenger RNA for FOXP3 in the urine of renal-allograft recipients.","volume":"353","author":"Muthukumar","year":"2005","journal-title":"N Engl J Med"},{"key":"R24-13-20210129","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1128\/JCM.37.2.327-332.1999","article-title":"High-throughput real-time reverse transcription-PCR quantitation of hepatitis C virus RNA.","volume":"37","author":"Martell","year":"1999","journal-title":"J Clin Microbiol"},{"key":"R25-13-20210129","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/0-387-32957-9_6","article-title":"Molecular genetics of the BK virus.","volume":"577","author":"Cubitt","year":"2006","journal-title":"Adv Exp Med Biol"},{"key":"R26-13-20210129","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1086\/431522","article-title":"Quantitation of DNA of polyomaviruses BK and JC in human kidneys.","volume":"192","author":"Randhawa","year":"2005","journal-title":"J Infect Dis"},{"key":"R27-13-20210129","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/01.tp.0000269706.59977.a5","article-title":"Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: A prospective evaluation.","volume":"84","author":"Drachenberg","year":"2007","journal-title":"Transplantation"},{"key":"R28-13-20210129","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"R29-13-20210129","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1136\/jcp.37.5.578","article-title":"Prospective study of the human polyomaviruses BK and JC and cytomegalovirus in renal transplant recipients.","volume":"37","author":"Gardner","year":"1984","journal-title":"J Clin Pathol"},{"key":"R30-13-20210129","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1097\/00007890-199903270-00022","article-title":"Polyomavirus disease under new immunosuppressive drugs: A cause of renal graft dysfunction and graft loss.","volume":"67","author":"Binet","year":"1999","journal-title":"Transplantation"},{"key":"R31-13-20210129","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1097\/00007890-199911150-00011","article-title":"Diagnosis and management of BK polyomavirus interstitial nephritis in renal transplant recipients.","volume":"68","author":"Howell","year":"1999","journal-title":"Transplantation"},{"key":"R32-13-20210129","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/0-387-32957-9_15","article-title":"Urine cytology findings of polyomavirus infections.","volume":"577","author":"Singh","year":"2006","journal-title":"Adv Exp Med Biol"},{"key":"R33-13-20210129","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1681\/ASN.2008010117","article-title":"Presence of urinary Haufen accurately predicts polyomavirus nephropathy.","volume":"20","author":"Singh","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"R34-13-20210129","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1086\/324425","article-title":"Prospective monitoring of BK virus load after discontinuing sirolimus treatment in a renal transplant patient with BK virus nephropathy.","volume":"84","author":"Hirsch","year":"2001","journal-title":"J Infect Dis"},{"key":"R35-13-20210129","first-page":"2141","article-title":"Fields' virology, vol II.","author":"Cole","year":"2001"},{"key":"R36-13-20210129","first-page":"2263","article-title":"Fields virology, vol 2.","author":"Imperiale","year":"2007"},{"key":"R37-13-20210129","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1111\/j.1523-1755.2005.00602.x","article-title":"BK virus nephritis: Risk factors, timing, and outcome in renal transplant recipients.","volume":"68","author":"Vasudev","year":"2005","journal-title":"Kidney Int"},{"key":"R38-13-20210129","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1600-6143.2004.00685.x","article-title":"BKV in simultaneous pancreas-kidney transplant recipients: A leading cause of renal graft loss in first 2 years post-transplant.","volume":"5","author":"Lipshutz","year":"2005","journal-title":"Am J Transplant"},{"key":"R39-13-20210129","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-065X.1995.tb00690.x","article-title":"Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis.","volume":"146","author":"Shresta","year":"1995","journal-title":"Immunol Rev"},{"key":"R40-13-20210129","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cellimm.2007.03.004","article-title":"Expression of high levels of human proteinase inhibitor 9 blocks both perforin\/granzyme and Fas\/Fas ligand-mediated cytotoxicity.","volume":"245","author":"Cunningham","year":"2007","journal-title":"Cell Immunol"},{"key":"R41-13-20210129","doi-asserted-by":"crossref","first-page":"27802","DOI":"10.1074\/jbc.271.44.27802","article-title":"A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes.","volume":"271","author":"Sun","year":"1996","journal-title":"J Biol Chem"},{"key":"R42-13-20210129","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1440-1797.2008.01050.x","article-title":"Immunophenotyping of interstitial infiltrate does not distinguish between BK virus nephropathy and acute cellular rejection.","volume":"14","author":"Rogers","year":"2009","journal-title":"Nephrology (Carlton)"},{"key":"R43-13-20210129","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1111\/j.1600-6143.2005.01096.x","article-title":"Molecular evaluation of BK polyomavirus nephropathy.","volume":"5","author":"Mannon","year":"2005","journal-title":"Am J Transplant"}],"container-title":["Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00007890-201007270-00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:22:08Z","timestamp":1786040528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00007890-201007270-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,27]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/tp.0b013e3181e2a932","relation":{},"ISSN":["0041-1337"],"issn-type":[{"value":"0041-1337","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7,27]]}}}