{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:21:11Z","timestamp":1786119671154,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2,27]]},"DOI":"10.1097\/tp.0b013e318204be15","type":"journal-article","created":{"date-parts":[[2010,12,30]],"date-time":"2010-12-30T05:39:52Z","timestamp":1293687592000},"page":"398-405","source":"Crossref","is-referenced-by-count":8,"title":["Embryonic Pig Pancreatic Tissue for the Treatment of Diabetes: Potential Role of Immune Suppression With \u201cOff-the-Shelf\u201d Third-Party Regulatory T Cells"],"prefix":"10.1097","volume":"91","author":[{"given":"Dalit","family":"Tchorsh-Yutsis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Zlotnikov Klionsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Bachar-Lustig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Aronovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Feine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Shezen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chava","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivka","family":"Bitcover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smadar","family":"Eventov-Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Katchman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Zangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orna","family":"Tal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivan","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Reisner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20210129","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1097\/00007890-199712150-00007","article-title":"Engraftment of human kidney tissue in rat radiation chimera: I. A new model of human kidney allograft rejection.","volume":"64","author":"Dekel","year":"1997","journal-title":"Transplantation"},{"key":"R2-5-20210129","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nm812","article-title":"Human and porcine early kidney precursors as a new source for transplantation.","volume":"9","author":"Dekel","year":"2003","journal-title":"Nat Med"},{"key":"R3-5-20210129","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/00000658-198610000-00008","article-title":"Fetal allograft survival in immunocompetent recipients is age dependent and organ specific.","volume":"204","author":"Foglia","year":"1986","journal-title":"Ann Surg"},{"key":"R4-5-20210129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trim.2005.03.020","article-title":"Windows of opportunity for organogenesis.","volume":"15","author":"Hammerman","year":"2005","journal-title":"Transplant Immunol"},{"key":"R5-5-20210129","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s00383-002-0856-6","article-title":"Organ-specific maturation of the major histocompatibility antigens in rats.","volume":"18","author":"Metzger","year":"2002","journal-title":"Pediatr Surg Int"},{"key":"R6-5-20210129","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0022-5347(17)42354-8","article-title":"Fetal and postnatal testis shows immunoprivilege as donor tissue.","volume":"139","author":"Statter","year":"1988","journal-title":"J Urol"},{"key":"R7-5-20210129","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s001090050326","article-title":"Fetal islet xenotransplantation in rodents and primates.","volume":"77","author":"Mandel","year":"1999","journal-title":"J Mol Med (Berlin, Germany)"},{"key":"R8-5-20210129","first-page":"1996","article-title":"Fetal islet transplantation.","volume":"24","author":"Mandel","year":"1992","journal-title":"Transplant Proc"},{"key":"R9-5-20210129","doi-asserted-by":"crossref","first-page":"19075","DOI":"10.1073\/pnas.0607012103","article-title":"Correction of hemophilia as a proof of concept for treatment of monogenic diseases by fetal spleen transplantation.","volume":"103","author":"Aronovich","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"R10-5-20210129","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1073\/pnas.0500177102","article-title":"Embryonic pig liver, pancreas, and lung as a source for transplantation: Optimal organogenesis without teratoma depends on distinct time windows.","volume":"102","author":"Eventov-Friedman","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"R11-5-20210129","doi-asserted-by":"crossref","first-page":"e215","DOI":"10.1371\/journal.pmed.0030215","article-title":"Embryonic pig pancreatic tissue transplantation for the treatment of diabetes.","volume":"3","author":"Eventov-Friedman","year":"2006","journal-title":"PLoS Med"},{"key":"R12-5-20210129","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1634\/stemcells.2007-0631","article-title":"Embryonic porcine liver as a source for transplantation: Advantage of intact liver implants over isolated hepatoblasts in overcoming homeostatic inhibition by the quiescent host liver.","volume":"26","author":"Katchman","year":"2008","journal-title":"Stem Cells (Dayton, Ohio)"},{"key":"R13-5-20210129","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.2337\/db09-0112","article-title":"Pig embryonic pancreatic tissue as a source for transplantation in diabetes: Transient treatment with anti-LFA1, anti-CD48 and FTY720 enables long term graft maintenance in mice with only mild ongoing immunosuppression.","volume":"58","author":"Tchorsh-Yutsis","year":"2009","journal-title":"Diabetes"},{"key":"R14-5-20210129","doi-asserted-by":"crossref","first-page":"8659","DOI":"10.1073\/pnas.0812253106","article-title":"Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model.","volume":"106","author":"Hecht","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"R15-5-20210129","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.2337\/db07-1712","article-title":"CD28\/CD154 blockade prevents autoimmune diabetes by inducing nondeletional tolerance after effector t-cell inhibition and regulatory T-cell expansion.","volume":"57","author":"Rigby","year":"2008","journal-title":"Diabetes"},{"key":"R16-5-20210129","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1097\/01.tp.0000244064.66136.04","article-title":"Costimulation blockade-induced cardiac allograft tolerance: Inhibition of T cell expansion and accumulation of intragraft cD4(+)Foxp3(+) T cells.","volume":"82","author":"Oderup","year":"2006","journal-title":"Transplantation"},{"key":"R17-5-20210129","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0966-3274(03)00016-9","article-title":"Simultaneous blockade of co- stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation.","volume":"12","author":"Guo","year":"2003","journal-title":"Transplant Immunol"},{"key":"R18-5-20210129","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.exphem.2006.02.017","article-title":"Overcoming T cell- mediated rejection of bone marrow allografts by T-regulatory cells: Synergism with veto cells and rapamycin.","volume":"34","author":"Steiner","year":"2006","journal-title":"Exp Hematol"},{"key":"R19-5-20210129","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.exphem.2005.10.011","article-title":"Tolerance induction by third-party \u201coff-the-shelf\u201d CD4+CD25+ Treg cells.","volume":"34","author":"Steiner","year":"2006","journal-title":"Exp Hematol"},{"key":"R20-5-20210129","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1182\/blood-2007-06-094482","article-title":"Differential impact of mammalian target of rapamycin inhibition on CD4+ CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells.","volume":"111","author":"Zeiser","year":"2008","journal-title":"Blood"},{"key":"R21-5-20210129","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.4049\/jimmunol.164.11.5761","article-title":"FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory.","volume":"164","author":"Pinschewer","year":"2000","journal-title":"J Immunol"},{"key":"R22-5-20210129","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0009-9120(98)00045-9","article-title":"Rapamune (RAPA, rapamycin, sirolimus): Mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression.","volume":"31","author":"Sehgal","year":"1998","journal-title":"Clin Biochem"},{"key":"R23-5-20210129","doi-asserted-by":"crossref","first-page":"7973","DOI":"10.4049\/jimmunol.175.12.7973","article-title":"The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+\/CD25+ T-regulatory cells and enhances their functional activity.","volume":"175","author":"Sawicka","year":"2005","journal-title":"J Immunol"},{"key":"R24-5-20210129","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1084\/jem.20040139","article-title":"In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.","volume":"199","author":"Tang","year":"2004","journal-title":"J Exp Med"},{"issue":"suppl 2","key":"R25-5-20210129","doi-asserted-by":"crossref","first-page":"14622","DOI":"10.1073\/pnas.0405234101","article-title":"Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells.","volume":"101","author":"Bluestone","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"R26-5-20210129","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1158\/1078-0432.CCR-06-0035","article-title":"Human regulatory T cells control xenogeneic graft-versus-host disease induced by autologous t cells in RAG2\u2212\/\u2212 \u03b3c\u2212\/\u2212 immunodeficient mice.","volume":"12","author":"Mutis","year":"2006","journal-title":"Clin Cancer Res"},{"key":"R27-5-20210129","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.4049\/jimmunol.181.4.2855","article-title":"CD28 costimulation is essential for human T regulatory expansion and function.","volume":"181","author":"Golovina","year":"2008","journal-title":"J Immunol"},{"key":"R28-5-20210129","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1172\/JCI28423","article-title":"Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling.","volume":"116","author":"Zanin-Zhorov","year":"2006","journal-title":"J Clin Invest"},{"key":"R29-5-20210129","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1084\/jem.20082824","article-title":"In vivo expansion of T reg cells with IL-2-mAb complexes: Induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.","volume":"206","author":"Webster","year":"2009","journal-title":"J Exp Med"},{"key":"R30-5-20210129","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nm1652","article-title":"Deacetylase inhibition promotes the generation and function of regulatory T cells.","volume":"13","author":"Tao","year":"2007","journal-title":"Nat Med"},{"key":"R31-5-20210129","doi-asserted-by":"crossref","first-page":"050507","DOI":"10.1117\/1.2364903","article-title":"Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing.","volume":"11","author":"Kalchenko","year":"2006","journal-title":"J Biomed Optics"}],"container-title":["Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/TP.0b013e318204be15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:53:40Z","timestamp":1786042420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00007890-201102270-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,27]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/tp.0b013e318204be15","relation":{},"ISSN":["0041-1337"],"issn-type":[{"value":"0041-1337","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2,27]]}}}