{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:16:26Z","timestamp":1791105386257,"version":"4.1.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,27]]},"DOI":"10.1097\/tp.0b013e318237d6d4","type":"journal-article","created":{"date-parts":[[2011,11,12]],"date-time":"2011-11-12T06:15:03Z","timestamp":1321078503000},"page":"1301-1308","source":"Crossref","is-referenced-by-count":52,"title":["Tolerance to Vascularized Composite Allografts in Canine Mixed Hematopoietic Chimeras"],"prefix":"10.1097","volume":"92","author":[{"given":"David W.","family":"Mathes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billanna","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott S.","family":"Graves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry E.","family":"Storer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Butts-Miwongtum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E.","family":"Sale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Nash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Storb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20210129","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1056\/NEJMoa020009","article-title":"The natural history of chronic allograft nephropathy.","volume":"349","author":"Nankivell","year":"2003","journal-title":"N Engl J Med"},{"key":"R2-3-20210129","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1600-6143.2004.00450.x","article-title":"Cancer after kidney transplantation in the United States.","volume":"4","author":"Kasiske","year":"2004","journal-title":"Am J Transplant"},{"key":"R3-3-20210129","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1365-2796.2007.01855.x","article-title":"Immune tolerance: Mechanisms and application in clinical transplantation (Review).","volume":"262","author":"Sykes","year":"2007","journal-title":"J Intern Med"},{"key":"R4-3-20210129","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/00007890-197111000-00014","article-title":"Acceptance of renal allografts in rat bone marrow chimeras.","volume":"12","author":"Guttmann","year":"1971","journal-title":"Transplantation"},{"key":"R5-3-20210129","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/00007890-199511000-00016","article-title":"Mixed allogeneic chimerism in the rat. Donor-specific transplantation tolerance without chronic rejection for primarily vascularized cardiac allografts.","volume":"60","author":"Colson","year":"1995","journal-title":"Transplantation"},{"key":"R6-3-20210129","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/01.tp.0000167724.38038.ae","article-title":"Robust tolerance to fully allogeneic islet transplants achieved by chimerism with minimal conditioning.","volume":"80","author":"Luo","year":"2005","journal-title":"Transplantation"},{"key":"R7-3-20210129","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00007890-200107150-00003","article-title":"Skin allograft rejection by stable hematopoietic chimeras that accept organ allografts still is an enigma [Letter].","volume":"72","author":"Steinmuller","year":"2001","journal-title":"Transplantation"},{"key":"R8-3-20210129","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1172\/JCI7913","article-title":"Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model.","volume":"105","author":"Huang","year":"2000","journal-title":"J Clin Invest"},{"key":"R9-3-20210129","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/00007890-200107150-00024","article-title":"Skin-specific alloantigens in miniature swine.","volume":"72","author":"Fuchimoto","year":"2001","journal-title":"Transplantation"},{"key":"R10-3-20210129","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00007890-200301150-00005","article-title":"Split tolerance to a composite tissue allograft in a swine model.","volume":"75","author":"Mathes","year":"2003","journal-title":"Transplantation"},{"key":"R11-3-20210129","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/01.TP.0000113806.52063.42","article-title":"Tolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine.","volume":"77","author":"Hettiaratchy","year":"2004","journal-title":"Transplantation"},{"key":"R12-3-20210129","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.transproceed.2009.01.015","article-title":"Induction of tolerance to an allogeneic skin flap transplant in a preclinical large animal model.","volume":"41","author":"Horner","year":"2009","journal-title":"Transplant Proc"},{"key":"R13-3-20210129","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/PRS.0b013e318200a92c","article-title":"Prolongation of composite tissue allotransplant survival by treatment with bone marrow mesenchymal stem cells is correlated with T-cell regulation in a swine hind-limb model.","volume":"127","author":"Kuo","year":"2011","journal-title":"Plast Reconstr Surg"},{"key":"R14-3-20210129","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1097\/TP.0b013e3181a664f1","article-title":"Mesenchymal stem cells prolong composite tissue allotransplant survival in a swine model.","volume":"87","author":"Kuo","year":"2009","journal-title":"Transplantation"},{"key":"R15-3-20210129","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/00007890-196611000-00003","article-title":"Immunologic relationships between skin and kidney homografts in dogs on immunosuppressive therapy.","volume":"4","author":"Moseley","year":"1966","journal-title":"Transplantation"},{"key":"R16-3-20210129","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/248796a0","article-title":"Differential survival of skin and heart allografts in radiation chimaeras provides further evidence for Sk histocompatibility antigen.","volume":"248","author":"Steinmuller","year":"1974","journal-title":"Nature"},{"key":"R17-3-20210129","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1182\/blood.V89.8.3048","article-title":"Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation.","volume":"89","author":"Storb","year":"1997","journal-title":"Blood"},{"key":"R18-3-20210129","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1182\/blood.V94.7.2523.419k18_2523_2529","article-title":"Stable mixed hematopoietic chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant.","volume":"94","author":"Storb","year":"1999","journal-title":"Blood"},{"key":"R19-3-20210129","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1097\/00007890-200205150-00020","article-title":"Tolerance to vascularized kidney grafts in canine mixed hematopoietic chimeras.","volume":"73","author":"Kuhr","year":"2002","journal-title":"Transplantation"},{"key":"R20-3-20210129","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/01.tp.0000270325.84036.52","article-title":"Long-term tolerance to kidney allografts in a preclinical canine model.","volume":"84","author":"Kuhr","year":"2007","journal-title":"Transplantation"},{"key":"R21-3-20210129","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1016\/S0041-1345(02)03614-X","article-title":"Survival of small bowel transplants in canine mixed hematopoietic chimeras: Preliminary results.","volume":"34","author":"Yunusov","year":"2002","journal-title":"Transplant Proc"},{"key":"R22-3-20210129","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1097\/TP.0b013e31820fafb4","article-title":"Evidence that FoxP3+ regulatory T cells may play a role in promoting long-term acceptance of composite tissue allotransplants.","volume":"91","author":"Bozulic","year":"2011","journal-title":"Transplantation"},{"key":"R23-3-20210129","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0140-6736(08)61277-5","article-title":"Repair of the lower and middle parts of the face by composite tissue allotransplantation in a patient with massive plexiform neurofibroma: A 1-year follow-up study.","volume":"372","author":"Lantieri","year":"2008","journal-title":"Lancet"},{"key":"R24-3-20210129","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/01.TP.0000157118.28394.FA","article-title":"The International Registry on Hand and Composite Tissue Transplantation.","volume":"79","author":"Lanzetta","year":"2005","journal-title":"Transplantation"},{"key":"R25-3-20210129","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(09)61155-7","article-title":"Near-total human face transplantation for a severely disfigured patient in the USA [Review].","volume":"374","author":"Siemionow","year":"2009","journal-title":"Lancet"},{"key":"R26-3-20210129","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.jhsa.2008.02.015","article-title":"Outcomes of the first 2 American hand transplants at 8 and 6 years posttransplant.","volume":"33","author":"Breidenbach","year":"2008","journal-title":"J Hand Surg Am"},{"key":"R27-3-20210129","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(08)61276-3","article-title":"Human facial allotransplantation: A 2-year follow-up study.","volume":"372","author":"Guo","year":"2008","journal-title":"Lancet"},{"key":"R28-3-20210129","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.transproceed.2009.01.013","article-title":"The Innsbruck hand transplant program: Update at 8 years after the first transplant.","volume":"41","author":"Brandacher","year":"2009","journal-title":"Transplant Proc"},{"key":"R29-3-20210129","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bjps.2007.11.019","article-title":"Composite tissue allotransplantation: A review of relevant immunological issues for plastic surgeons [Review].","volume":"61","author":"Whitaker","year":"2008","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"R30-3-20210129","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bjps.2004.02.012","article-title":"Composite tissue allotransplantation\u2014A new era in plastic surgery? (Review).","volume":"57","author":"Hettiaratchy","year":"2004","journal-title":"Br J Plast Surg"},{"key":"R31-3-20210129","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev.med.52.1.353","article-title":"Mixed chimerism and transplantation tolerance [Review].","volume":"52","author":"Wekerle","year":"2001","journal-title":"Annu Rev Med"},{"key":"R32-3-20210129","doi-asserted-by":"crossref","first-page":"540","DOI":"10.4049\/jimmunol.114.2_Part_1.540","article-title":"Canine radiation chimeras: An attempt to demonstrate serum blocking factors by an in vivo approach.","volume":"114","author":"Schroeder","year":"1975","journal-title":"J Immunol"},{"key":"R33-3-20210129","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/01.TP.0000045224.52516.FC","article-title":"Adoptive immunotherapy against kidney targets in dog-leukocyte antigen-identical mixed hematopoietic canine chimeras.","volume":"75","author":"Junghanss","year":"2003","journal-title":"Transplantation"},{"key":"R34-3-20210129","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.bbmt.2008.08.005","article-title":"Adoptive immunotherapy against allogeneic kidney grafts in dogs with stable hematopoietic trichimerism.","volume":"14","author":"Graves","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"key":"R35-3-20210129","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1172\/JCI106605","article-title":"Marrow grafts between canine siblings matched by serotyping and mixed leukocyte culture.","volume":"50","author":"Storb","year":"1971","journal-title":"J Clin Invest"},{"key":"R36-3-20210129","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1097\/00007890-199611150-00016","article-title":"Pattern of liver, kidney, heart, and intestine allograft rejection in different mouse strain combinations.","volume":"62","author":"Zhang","year":"1996","journal-title":"Transplantation"},{"key":"R37-3-20210129","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00007890-198507000-00006","article-title":"Lung allograft rejection in the rat. I. Accelerated rejection caused by graft lymphocytes.","volume":"40","author":"Prop","year":"1985","journal-title":"Transplantation"},{"key":"R38-3-20210129","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000154854","article-title":"Interaction of regulatory T cells with antigen-presenting cells in health and disease (Review).","volume":"94","author":"Mahnke","year":"2008","journal-title":"Chem Immunol Allergy"},{"key":"R39-3-20210129","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1097\/01.tp.0000250937.46187.ca","article-title":"Isolation of regulatory T cells in the skin of a human hand-allograft, up to six years posttransplantation.","volume":"82","author":"Eljaafari","year":"2006","journal-title":"Transplantation"},{"key":"R40-3-20210129","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.bbmt.2009.04.009","article-title":"Increase in FOXP3+ regulatory T cells in GVHD skin biopsies is associated with lower disease severity and treatment response.","volume":"15","author":"Fondi","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"R41-3-20210129","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/j.1600-6143.2009.02619.x","article-title":"Immunomodulatory effects of mixed hematopoietic chimerism: Immune tolerance in canine model of lung transplantation.","volume":"9","author":"Nash","year":"2009","journal-title":"Am J Transplant"},{"key":"R42-3-20210129","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/TP.0b013e31820f07ff","article-title":"Antagonistic and agonistic anti-canine CD28 monoclonal antibodies: Tools for allogeneic transplantation.","volume":"91","author":"Graves","year":"2011","journal-title":"Transplantation"},{"key":"R43-3-20210129","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1056\/NEJMoa051907","article-title":"Messenger RNA for FOXP3 in the urine of renal-allograft recipients.","volume":"353","author":"Muthukumar","year":"2005","journal-title":"N Engl J Med"},{"key":"R44-3-20210129","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1399-0039.1996.tb02668.x","article-title":"Molecular analysis of the DLA DR region.","volume":"48","author":"Wagner","year":"1996","journal-title":"Tissue Antigens"},{"key":"R45-3-20210129","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1399-0039.1998.tb03039.x","article-title":"Molecular analysis and polymorphism of the DLA-DQB genes.","volume":"52","author":"Wagner","year":"1998","journal-title":"Tissue Antigens"},{"key":"R46-3-20210129","first-page":"11","article-title":"Canine models of bone marrow transplantation.","volume":"40","author":"Ladiges","year":"1990","journal-title":"Lab Anim Sci"},{"key":"R47-3-20210129","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/00007890-199409270-00011","article-title":"Use of (CA)n polymorphisms to determine the origin of blood cells after allogeneic canine marrow grafting.","volume":"58","author":"Yu","year":"1994","journal-title":"Transplantation"},{"key":"R48-3-20210129","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1182\/blood-2007-02-071282","article-title":"Stable trichimerism after marrow grafting from 2 DLA-identical canine donors and nonmyeloablative conditioning.","volume":"110","author":"Graves","year":"2007","journal-title":"Blood"},{"key":"R49-3-20210129","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1055\/s-0030-1247717","article-title":"A preclinical canine model for composite tissue transplantation.","volume":"26","author":"Mathes","year":"2010","journal-title":"J Reconstr Microsurg"},{"key":"R50-3-20210129","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1399-0039.1983.tb00185.x","article-title":"The canine major histocompatibility complex. Population study of DLA-D alleles using a panel of homozygous typing cells.","volume":"21","author":"Raff","year":"1983","journal-title":"Tissue Antigens"}],"container-title":["Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/TP.0b013e318237d6d4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:23:58Z","timestamp":1786047838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00007890-201112270-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,27]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/tp.0b013e318237d6d4","relation":{},"ISSN":["0041-1337"],"issn-type":[{"value":"0041-1337","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12,27]]}}}