{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:34:33Z","timestamp":1793363673568,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background.<\/jats:title>\n                    <jats:p>Older donor livers have higher rates of biliary complications after transplantation, but early mechanisms of bile duct injury remain incompletely understood. Peribiliary glands (PBGs) in the bile duct wall contain progenitor-like and secretory elements that may support epithelial maintenance and repair. We examined whether donor age is associated with early PBG injury and recovery and explored links with the basement-membrane component laminin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Livers from young or aged rats were transplanted into young recipients. Extrahepatic bile ducts were evaluated before transplantation and at 24, 72, and 168\u2009h after liver transplantation. PBG morphology and detachment, laminin \u03b31 expression, and markers related to progenitor-cell characteristics, mucus production, microvascular density, and apoptosis were assessed histologically and immunohistochemically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>In aged donor grafts, PBGs showed progressive structural injury after transplantation, with marked cell detachment and loss of glandular architecture at 168\u2009h. In contrast, PBGs in young donor grafts were largely preserved. Areas of PBG cell detachment in aged grafts were spatially associated with reduced laminin \u03b31 expression. Recovery of laminin \u03b31 expression over time was less evident in aged grafts and was accompanied by impaired progenitor-cell marker expression, reduced mucus production, persistently decreased microvascular density, and increased shedding of apoptotic PBG cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Aged donor grafts showed more pronounced early structural PBG injury after transplantation, together with persistent reduction of laminin \u03b31 expression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/txd.0000000000001981","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:00:17Z","timestamp":1783353617000},"page":"e1981","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Peribiliary Gland Detachment in Aged Donor Grafts After Rat Liver Transplantation"],"prefix":"10.1097","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0795-7193","authenticated-orcid":false,"given":"Kaoru","family":"Katano","sequence":"first","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Nakanuma","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sugio","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Horio","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaichiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Iwao","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isamu","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-5761","authenticated-orcid":false,"given":"Shintaro","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"R1-20261030","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.3748\/wjg.v29.i21.3257","article-title":"Biliary complications after liver transplantation: a computed tomography and magnetic resonance imaging pictorial review.","volume":"29","author":"Vernuccio","year":"2023","journal-title":"World J Gastroenterol"},{"key":"R2-20261030","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00534-005-1080-2","article-title":"Causes and consequences of ischemic-type biliary lesions after 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