{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:14:47Z","timestamp":1772838887372,"version":"3.50.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1097\/wad.0b013e3181572046","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T14:16:42Z","timestamp":1236262602000},"page":"177-180","source":"Crossref","is-referenced-by-count":9,"title":["The Sp1\/Egr1-tandem Repeat Polymorphism in the 5-Lipoxygenase Gene Promoter is not Associated With Late Onset Alzheimer Disease"],"prefix":"10.1097","volume":"22","author":[{"given":"Victoria","family":"Alvarez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pelayo","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana I.","family":"Corao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Men\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos H.","family":"Lahoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maite","family":"Calatayud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliecer","family":"Coto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-14-20210128","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1046\/j.1525-1381.1999.t01-1-99231.x","article-title":"The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms","volume":"111","author":"Silverman","year":"1999","journal-title":"Proc Assoc Am Physicians"},{"key":"R2-14-20210128","doi-asserted-by":"crossref","first-page":"12852","DOI":"10.1073\/pnas.91.26.12852","article-title":"Altered inflammatory responses in leukotriene-deficient mice","volume":"91","author":"Goulet","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"R3-14-20210128","doi-asserted-by":"crossref","first-page":"684","DOI":"10.7326\/0003-4819-121-9-199411010-00010","article-title":"The role of leukotrienes in inflammation","volume":"121","author":"Henderson","year":"1994","journal-title":"Ann Intern Med"},{"key":"R4-14-20210128","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.tins.2005.02.001","article-title":"Neurovascular mechanisms of Alzheimer's neurodegeneration","volume":"28","author":"Zlokovic","year":"2005","journal-title":"Trends Neurosci"},{"key":"R5-14-20210128","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00702-004-0188-x","article-title":"Alzheimer's associated inflammation, potential drug targets and future therapies","volume":"112","author":"Stuchbury","year":"2005","journal-title":"LJ Neural Transm"},{"issue":"2","key":"R6-14-20210128","doi-asserted-by":"crossref","first-page":"S435","DOI":"10.1016\/S0197-4580(04)81434-9","article-title":"5-lipoxygenase protein is elevated in the hippocampus of Alzheimer's disease patients","volume":"25","author":"Ikonomovic","year":"2004","journal-title":"Neurobiol Aging"},{"key":"R7-14-20210128","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.mehy.2005.09.031","article-title":"5-lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease","volume":"66","author":"Manev","year":"2006","journal-title":"Med Hypoth"},{"key":"R8-14-20210128","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1176\/jnp.13.2.304","article-title":"5-lipoxygenase (5-LOX) promoter polymorphism in patients with early and late-onset Alzheimer's disease","volume":"13","author":"Qu","year":"2001","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"R9-14-20210128","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1172\/JCI119241","article-title":"Naturally occurring mutations in the human 5-lipoxygensase gene promoter that modify transcription factor binding and reporter gene transcription","volume":"99","author":"In","year":"1997","journal-title":"J Clin Invest"},{"key":"R10-14-20210128","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1056\/NEJMoa025079","article-title":"Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis","volume":"350","author":"Dwyer","year":"2004","journal-title":"N Engl J Med"},{"key":"R11-14-20210128","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/9680","article-title":"Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment","volume":"22","author":"Drazen","year":"1999","journal-title":"Nat Genet"},{"key":"R12-14-20210128","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1398-9995.2006.00979.x","article-title":"ALOX5 promoter genotype, asthma severity and LTC production by eosinophils","volume":"61","author":"Kalayci","year":"2006","journal-title":"Allergy"},{"key":"R13-14-20210128","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/0140-6736(91)92823-K","article-title":"Apolipoprotein E genotyping by one-stage PCR","volume":"337","author":"Wenham","year":"1991","journal-title":"Lancet"},{"key":"R14-14-20210128","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/372179a0","article-title":"Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene","volume":"372","author":"Chen","year":"1994","journal-title":"Nature"},{"key":"R15-14-20210128","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00228-002-0458-1","article-title":"5-lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists","volume":"58","author":"Fowler","year":"2002","journal-title":"Eur J Clin Pharmacol"},{"key":"R16-14-20210128","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ng1311","article-title":"The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infraction and stroke","volume":"36","author":"Helgadottir","year":"2004","journal-title":"Nat Genet"},{"key":"R17-14-20210128","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/ng1692","article-title":"A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction","volume":"38","author":"Helgadottir","year":"2006","journal-title":"Nat Genet"},{"key":"R18-14-20210128","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1161\/01.ATV.0000172632.96987.2d","article-title":"Association between 5-lipoxygenase expression and plaque instability in humans","volume":"25","author":"Cipollone","year":"2005","journal-title":"Art Thromb Vasc Biol"},{"key":"R19-14-20210128","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1164\/ajrccm.161.supplement_1.ltta-16","article-title":"Genetic variations in the 5-lipoxygenase core promoter: description and functional implications","volume":"161","author":"Silverman","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"R20-14-20210128","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1744-313X.2007.00671.x","article-title":"A functional Sp1\/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene is not associated with myocardial infarction","volume":"34","author":"Gonz\u00e1lez","year":"2007","journal-title":"Int J Immunogenet"},{"key":"R21-14-20210128","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1172\/JCI24761","article-title":"The genetic epidemiology of neurodegenerative disease","volume":"115","author":"Bertram","year":"2005","journal-title":"J Clin Invest"},{"key":"R22-14-20210128","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(01)00476-7","article-title":"New frontiers in Alzheimer's disease genetics","volume":"32","author":"Tanzi","year":"2001","journal-title":"Neuron"},{"key":"R23-14-20210128","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1001\/archneur.1991.00530150037014","article-title":"Risk of dementia in first-degree relatives of patients with Alzheimer's disease and related disorders","volume":"48","author":"Mayeux","year":"1991","journal-title":"Arch Neurol"},{"key":"R24-14-20210128","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: high activity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"R25-14-20210128","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.20.9649","article-title":"Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease","volume":"90","author":"Schmechel","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"R26-14-20210128","first-page":"441","article-title":"Frequency of the APOE-4 allele in Alzheimer's disease and its variation with age in Asturias (Spain)","volume":"113","author":"Alvarez","year":"1999","journal-title":"Med Clin (Barc)"},{"key":"R27-14-20210128","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/00002093-199601040-00002","article-title":"Accuracy of clinical diagnosis of Alzheimer disease and clinical features of patients with non-Alzheimer disease neuropathology","volume":"10","author":"Rasmusson","year":"1996","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"R28-14-20210128","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1212\/01.WNL.0000150886.50187.30","article-title":"Atherosclerosis and AD. Analysis of data from the US National Alzheimer's Coordinating Center","volume":"64","author":"Honig","year":"2005","journal-title":"Neurology"},{"key":"R29-14-20210128","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/01.STR.26.5.743","article-title":"Relation of coronary atherosclerosis and apolipoprotein E genotypes in Alzheimer patients","volume":"26","author":"Kosunen","year":"1995","journal-title":"Stroke"}],"container-title":["Alzheimer Disease & Associated Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00002093-200804000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T01:48:56Z","timestamp":1618278536000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00002093-200804000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/wad.0b013e3181572046","relation":{},"ISSN":["0893-0341"],"issn-type":[{"value":"0893-0341","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}