{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:14:38Z","timestamp":1771503278370,"version":"3.50.1"},"reference-count":70,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Neurology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1097\/wco.0000000000000067","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T12:26:57Z","timestamp":1392812817000},"page":"227-235","source":"Crossref","is-referenced-by-count":69,"title":["Antiepileptogenesis in humans"],"prefix":"10.1097","volume":"27","author":[{"given":"Eugen","family":"Trinka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Brigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-14-20140228","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/epi.12293","volume":"54","author":"Galanopoulou","year":"2013","journal-title":"Epilepsia"},{"key":"R2-14-20140228","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1528-1167.2011.03391.x","volume":"53","author":"Galanopoulou","year":"2012","journal-title":"Epilepsia"},{"key":"R3-14-20140228","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/epi.12294","volume":"54","author":"French","year":"2013","journal-title":"Epilepsia"},{"key":"R4-14-20140228","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/epi.12295","volume":"54","author":"Galanopoulou","year":"2013","journal-title":"Epilepsia"},{"key":"R5-14-20140228","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/epi.12296","volume":"54","author":"Wilcox","year":"2013","journal-title":"Epilepsia"},{"key":"R6-14-20140228","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/epi.12297","volume":"54","author":"Pitkanen","year":"2013","journal-title":"Epilepsia"},{"key":"R7-14-20140228","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/epi.12298","volume":"54","author":"Brooks-Kayal","year":"2013","journal-title":"Epilepsia"},{"key":"R8-14-20140228","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/epi.12299","volume":"54","author":"Engel","year":"2013","journal-title":"Epilepsia"},{"key":"R10-14-20140228","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/WCO.0b013e32835efe29","volume":"26","author":"Simonato","year":"2013","journal-title":"Curr Opin Neurol"},{"key":"R11-14-20140228","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1528-1167.2010.02602.x","volume":"51","author":"Pitkanen","year":"2010","journal-title":"Epilepsia"},{"key":"R12-14-20140228","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1474-4422(10)70310-0","volume":"10","author":"Pitkanen","year":"2011","journal-title":"Lancet Neurol"},{"key":"R13-14-20140228","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1046\/j.1528-1157.2001.28900.x","volume":"42","author":"Temkin","year":"2001","journal-title":"Epilepsia"},{"key":"R14-14-20140228","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/j.1528-1167.2008.01726.x","volume":"50","author":"Adelow","year":"2009","journal-title":"Epilepsia"},{"key":"R15-14-20140228","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1001\/archneurol.2009.10","volume":"66","author":"Dichter","year":"2009","journal-title":"Arch Neurol"},{"key":"R16-14-20140228","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1684\/epd.2012.0512","volume":"14","author":"Schmidt","year":"2012","journal-title":"Epileptic Disord"},{"key":"R17-14-20140228","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1528-1167.2008.01931.x","volume":"49","author":"Sloviter","year":"2008","journal-title":"Epilepsia"},{"key":"R18-14-20140228","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuropharm.2012.01.022","volume":"69","author":"Sloviter","year":"2013","journal-title":"Neuropharmacology"},{"key":"R19-14-20140228","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1528-1167.2008.02005.x","volume":"50","author":"Temkin","year":"2009","journal-title":"Epilepsia"},{"key":"R20-14-20140228","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1056\/NEJMoa0902014","volume":"362","author":"Glauser","year":"2010","journal-title":"N Engl J Med"},{"key":"R21-14-20140228","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1528-1167.2007.01458.x","volume":"49","author":"Blumenfeld","year":"2008","journal-title":"Epilepsia"},{"key":"R22-14-20140228","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1111\/j.1528-1167.2009.02400.x","volume":"51","author":"Russo","year":"2010","journal-title":"Epilepsia"},{"key":"R23-14-20140228","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/j.1528-1167.2011.03112.x","volume":"52","author":"Russo","year":"2011","journal-title":"Epilepsia"},{"key":"R24-14-20140228","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.nbd.2013.08.013","volume":"60","author":"van Luijtelaar","year":"2013","journal-title":"Neurobiol Dis"},{"key":"R25-14-20140228","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/epi.12118","volume":"54","author":"Dezsi","year":"2013","journal-title":"Epilepsia"},{"key":"R26-14-20140228","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1111\/epi.12148","volume":"54","author":"Neligan","year":"2013","journal-title":"Epilepsia"},{"key":"R27-14-20140228","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1001\/archneurol.2012.1200","volume":"69","author":"Van Gompel","year":"2012","journal-title":"Arch Neurol"},{"key":"R28-14-20140228","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1212\/WNL.0b013e318250d7ea","volume":"78","author":"Englot","year":"2012","journal-title":"Neurology"},{"key":"R30-14-20140228","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1528-1157.44.s10.1.x","volume":"44","author":"Beghi","year":"2003","journal-title":"Epilepsia"},{"key":"R31-14-20140228","first-page":"CD000173","volume":"4","author":"Schierhout","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"R32-14-20140228","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/jnnp.23.4.295","volume":"23","author":"Jennett","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R33-14-20140228","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0140-6736(69)91822-4","volume":"1","author":"Jennett","year":"1969","journal-title":"Lancet"},{"key":"R34-14-20140228","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1212\/01.WNL.0000031432.05543.14","volume":"60","author":"Chang","year":"2003","journal-title":"Neurology"},{"key":"R35-14-20140228","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/TA.0b013e3182826e84","volume":"74","author":"Inaba","year":"2013","journal-title":"J Trauma Acute Care Surg"},{"key":"R36-14-20140228","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/TA.0b013e318224d307","volume":"71","author":"Cotton","year":"2011","journal-title":"J Trauma"},{"key":"R37-14-20140228","first-page":"66","volume":"26","author":"Glotzner","year":"1983","journal-title":"Neurochirurgia (Stuttg)"},{"key":"R38-14-20140228","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/jnnp.46.10.899","volume":"46","author":"McQueen","year":"1983","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R39-14-20140228","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3171\/jns.1983.58.2.0236","volume":"58","author":"Young","year":"1983","journal-title":"J Neurosurg"},{"key":"R40-14-20140228","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3171\/jns.1983.58.2.0231","volume":"58","author":"Young","year":"1983","journal-title":"J Neurosurg"},{"key":"R41-14-20140228","first-page":"185","volume":"10","author":"Young","year":"1983","journal-title":"Childs Brain"},{"key":"R42-14-20140228","first-page":"841","volume":"20","author":"Pechadre","year":"1991","journal-title":"Presse Med"},{"key":"R43-14-20140228","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJM199008233230801","volume":"323","author":"Temkin","year":"1990","journal-title":"N Engl J Med"},{"key":"R44-14-20140228","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1001\/jama.1991.03460100073027","volume":"265","author":"Dikmen","year":"1991","journal-title":"JAMA"},{"key":"R45-14-20140228","first-page":"311","volume":"46","author":"Manaka","year":"1992","journal-title":"Jpn J Psychiatry Neurol"},{"key":"R46-14-20140228","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.01.006","volume":"21","author":"Okuda","year":"2012","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"R47-14-20140228","first-page":"CD005398","volume":"6","author":"Kwan","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"R48-14-20140228","first-page":"CD008710","volume":"6","author":"Marigold","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"R49-14-20140228","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.seizure.2010.12.012","volume":"20","author":"van Tuijl","year":"2011","journal-title":"Seizure"},{"key":"R50-14-20140228","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1212\/WNL.67.12_suppl_4.S10","volume":"67","author":"Vecht","year":"2006","journal-title":"Neurology"},{"key":"R51-14-20140228","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1212\/WNL.38.2.194","volume":"38","author":"Delattre","year":"1988","journal-title":"Neurology"},{"key":"R52-14-20140228","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/j.seminoncol.2003.11.030","volume":"30","author":"Vecht","year":"2003","journal-title":"Semin Oncol"},{"key":"R53-14-20140228","first-page":"CD004424","volume":"2","author":"Tremont-Lukats","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"R54-14-20140228","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3171\/jns.1983.58.5.0672","volume":"58","author":"North","year":"1983","journal-title":"J Neurosurg"},{"key":"R55-14-20140228","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0090-3019(89)90067-0","volume":"31","author":"Lee","year":"1989","journal-title":"Surg Neurol"},{"key":"R56-14-20140228","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF01420191","volume":"103","author":"Franceschetti","year":"1990","journal-title":"Acta Neurochir (Wien)"},{"key":"R57-14-20140228","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1212\/WNL.46.4.985","volume":"46","author":"Glantz","year":"1996","journal-title":"Neurology"},{"key":"R58-14-20140228","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1017\/S0317167100053361","volume":"30","author":"Forsyth","year":"2003","journal-title":"Can J Neurol Sci"},{"key":"R59-14-20140228","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1212\/WNL.0b013e31822f02e1","volume":"77","author":"Weller","year":"2011","journal-title":"Neurology"},{"key":"R60-14-20140228","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ijrobp.2013.02.012","volume":"86","author":"Barker","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R61-14-20140228","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/neuonc\/not057","volume":"15","author":"Kerkhof","year":"2013","journal-title":"Neuro Oncol"},{"key":"R62-14-20140228","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3109\/02688697.2011.638996","volume":"26","author":"Tsai","year":"2012","journal-title":"Br J Neurosurg"},{"key":"R63-14-20140228","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1124\/pr.110.003046","volume":"62","author":"Loscher","year":"2010","journal-title":"Pharmacol Rev"},{"key":"R64-14-20140228","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s11910-012-0276-5","volume":"12","author":"Ryther","year":"2012","journal-title":"Curr Neurol Neurosci Rep"},{"key":"R65-14-20140228","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1126\/science.1076510","volume":"298","author":"Cohen","year":"2002","journal-title":"Science"},{"key":"R66-14-20140228","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/nm1301","volume":"11","author":"Dzhala","year":"2005","journal-title":"Nat Med"},{"key":"R67-14-20140228","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/nm.2850","volume":"18","author":"Koyama","year":"2012","journal-title":"Nat Med"},{"key":"R68-14-20140228","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","volume":"7","author":"Vezzani","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"R69-14-20140228","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1528-1167.2011.03242.x","volume":"52","author":"Vezzani","year":"2011","journal-title":"Epilepsia"},{"key":"R70-14-20140228","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.eplepsyres.2012.10.001","volume":"103","author":"Bialer","year":"2013","journal-title":"Epilepsy Res"},{"key":"R71-14-20140228","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.neulet.2011.03.010","volume":"497","author":"Mani","year":"2011","journal-title":"Neurosci Lett"},{"key":"R72-14-20140228","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrd4126","volume":"12","author":"Loscher","year":"2013","journal-title":"Nat Rev Drug Discov"}],"container-title":["Current Opinion in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/WCO.0000000000000067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T07:53:29Z","timestamp":1620978809000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.lww.com\/00019052-201404000-00014"}},"subtitle":["disappointing clinical evidence and ways to move forward"],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":70,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1097\/wco.0000000000000067","relation":{},"ISSN":["1350-7540"],"issn-type":[{"value":"1350-7540","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}