{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:27:00Z","timestamp":1762100820114},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1097\/wco.0b013e3282fd171a","type":"journal-article","created":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T07:02:21Z","timestamp":1209625341000},"page":"288-293","source":"Crossref","is-referenced-by-count":23,"title":["Genetics of migraine: an update with special attention to genetic comorbidity"],"prefix":"10.1097","volume":"21","author":[{"given":"Anine H","family":"Stam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arn MJM","family":"van den Maagdenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost","family":"Haan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela M","family":"Terwindt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel D","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-12-20210206","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00018-006-5592-y","article-title":"The search for migraine genes: an overview of current knowledge","volume":"64","author":"Colson","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"R2-12-20210206","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1001\/archneur.64.5.643","article-title":"Genetic models of migraine","volume":"64","author":"Van de Ven","year":"2007","journal-title":"Arch Neurol"},{"key":"R3-12-20210206","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/WCO.0b013e3281338d1f","article-title":"Migraine: gene mutations and functional consequences","volume":"20","author":"Van den Maagdenberg","year":"2007","journal-title":"Curr Opin Neurol"},{"key":"R4-12-20210206","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S1474-4422(07)70126-6","article-title":"M, Terwindt GM, Kaunisto, et al. Migraine: a complex genetic disorder.","volume":"6","year":"2007","journal-title":"Lancet Neurol"},{"key":"R5-12-20210206","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s10194-007-0389-4","article-title":"Genetics in primary headaches","volume":"8","author":"Russell","year":"2007","journal-title":"J Headache Pain"},{"key":"R6-12-20210206","first-page":"1","article-title":"2nd Edition.","volume":"24","year":"2004","journal-title":"Cephalalgia"},{"key":"R7-12-20210206","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/brain\/awl334","article-title":"The genetic spectrum of a population-based sample of familial hemiplegic migraine","volume":"130","author":"Thomsen","year":"2007","journal-title":"Brain"},{"key":"R8-12-20210206","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jns.2007.01.008","article-title":"Early-onset progressive ataxia associated with the first CACNA1A mutation identified within the I-II loop","volume":"254","author":"Cricchi","year":"2007","journal-title":"J Neurol Sci"},{"key":"R9-12-20210206","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0092-8674(00)81373-2","article-title":"Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4","volume":"87","author":"Ophoff","year":"1996","journal-title":"Cell"},{"key":"R10-12-20210206","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1399-0004.2007.00892.x","article-title":"Amino acid changes in the amino terminus of the Na, K-adenosine triphosphatase alpha-2 subunit associated to familial and sporadic hemiplegic migraine","volume":"72","author":"Tonelli","year":"2007","journal-title":"Clin Genet"},{"key":"R11-12-20210206","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/sj.ejhg.5201841","article-title":"First case of compound heterozygosity in Na, K-ATPase gene ATP1A2 in familial hemiplegic migraine","volume":"15","author":"Vanmolkot","year":"2007","journal-title":"Eur J Hum Genet"},{"key":"R12-12-20210206","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1399-0004.2007.00918.x","article-title":"Two novel functional mutations in the Na(+), K(+)-ATPase alpha2-subunit ATP1A2 gene in patients with familial hemiplegic migraine and associated neurological phenotypes","volume":"73","author":"Castro","year":"2008","journal-title":"Clin Genet"},{"key":"R13-12-20210206","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1212\/01.WNL.0000127310.11526.FD","article-title":"Variability of familial hemiplegic migraine with novel A1A2 Na+\/K+-ATPase variants","volume":"62","author":"Jurkat-Rott","year":"2004","journal-title":"Neurology"},{"key":"R14-12-20210206","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/jnnp.2006.103267","article-title":"Prolonged hemiplegic episodes in children due to mutations in ATP1A2","volume":"78","author":"Jen","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R15-12-20210206","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/ana.20760","article-title":"Severe episodic neurological deficits and permanent mental retardation in a child with a novel FHM2 ATP1A2 mutation","volume":"59","author":"Vanmolkot","year":"2006","journal-title":"Ann Neurol"},{"key":"R16-12-20210206","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1528-1167.2007.01415.x","article-title":"Epilepsy as part of the phenotype associated with ATP1A2 mutations","volume":"49","author":"Deprez","year":"2008","journal-title":"Epilepsia"},{"key":"R17-12-20210206","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/ana.10674","article-title":"Novel mutations in the Na+, K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions","volume":"54","author":"Vanmolkot","year":"2003","journal-title":"Ann Neurol"},{"key":"R18-12-20210206","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/ng1081","article-title":"Haploinsufficiency of ATP1A2 encoding the Na+\/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2","volume":"33","author":"De Fusco","year":"2003","journal-title":"Nat Genet"},{"key":"R19-12-20210206","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1526-4610.2007.00848.x","article-title":"A Novel ATP1A2 gene mutation in an Irish familial hemiplegic migraine kindred","volume":"48","author":"Fernandez","year":"2008","journal-title":"Headache"},{"key":"R20-12-20210206","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/humu.9361","article-title":"ATP1A2 mutations in 11 families with familial hemiplegic migraine","volume":"26","author":"Riant","year":"2005","journal-title":"Hum Mutat"},{"key":"R21-12-20210206","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s10038-007-0205-7","article-title":"Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine","volume":"52","author":"Castro","year":"2007","journal-title":"J Hum Genet"},{"key":"R22-12-20210206","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0140-6736(05)66786-4","article-title":"Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine","volume":"366","author":"Dichgans","year":"2005","journal-title":"Lancet"},{"key":"R23-12-20210206","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1172\/JCI25466","article-title":"Sodium channel mutations in epilepsy and other neurological disorders","volume":"115","author":"Meisler","year":"2005","journal-title":"J Clin Invest"},{"key":"R24-12-20210206","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/humu.20178","article-title":"SCN1A mutations and epilepsy","volume":"25","author":"Mulley","year":"2005","journal-title":"Hum Mutat"},{"key":"R25-12-20210206","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/humu.9486","article-title":"The novel p.L1649Q mutation in the SCN1A epilepsy gene is associated with familial hemiplegic migraine: genetic and functional studies. Mutation in brief #957. Online","volume":"28","author":"Vanmolkot","year":"2007","journal-title":"Hum Mutat"},{"key":"R26-12-20210206","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pediatrneurol.2007.06.016","article-title":"Novel mutation confirms seizure locus SCN1A is also familial hemiplegic migraine locus FHM3","volume":"37","author":"Gargus","year":"2007","journal-title":"Pediatr Neurol"},{"key":"R27-12-20210206","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1212\/01.wnl.0000295670.01629.5a","article-title":"Systematic analysis of three FHM genes in 39 sporadic patients with hemiplegic migraine","volume":"69","author":"De Vries","year":"2007","journal-title":"Neurology"},{"key":"R28-12-20210206","doi-asserted-by":"crossref","first-page":"23944","DOI":"10.1016\/S0021-9258(19)51029-8","article-title":"Functional consequences of amino-terminal diversity of the catalytic subunit of the Na, K-ATPase","volume":"269","author":"Daly","year":"1994","journal-title":"J Biol Chem"},{"key":"R29-12-20210206","doi-asserted-by":"crossref","first-page":"9239","DOI":"10.1074\/jbc.275.13.9239","article-title":"Three new familial hemiplegic migraine mutants affect P\/Q-type Ca(2+) channel kinetics","volume":"275","author":"Kraus","year":"2000","journal-title":"J Biol Chem"},{"key":"R30-12-20210206","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1468-2982.2006.01231.x","article-title":"Haemochromatosis gene (HFE) polymorphisms and migraine: an association study","volume":"27","author":"Rainero","year":"2007","journal-title":"Cephalalgia"},{"key":"R31-12-20210206","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1468-2982.2007.01254.x","article-title":"An adenosine A2A receptor gene haplotype is associated with migraine with aura","volume":"27","author":"Hohoff","year":"2007","journal-title":"Cephalalgia"},{"key":"R32-12-20210206","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jocn.2006.04.018","article-title":"The A218C polymorphism of tryptophan hydroxylase gene and migraine","volume":"14","author":"Erdal","year":"2007","journal-title":"J Clin Neurosci"},{"key":"R33-12-20210206","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1468-2982.2006.01269.x","article-title":"Combined effects of ACE and MMP-3 polymorphisms on migraine development","volume":"27","author":"Kara","year":"2007","journal-title":"Cephalalgia"},{"key":"R35-12-20210206","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-2350-8-57","article-title":"Association analysis of chromosome 1 migraine candidate genes","volume":"8","author":"Fernandez","year":"2007","journal-title":"BMC Med Genet"},{"key":"R36-12-20210206","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10048-001-0125-1","article-title":"A typical migraine susceptibility region localizes to chromosome 1q31","volume":"4","author":"Lea","year":"2002","journal-title":"Neurogenetics"},{"key":"R37-12-20210206","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1179\/016164105X39978","article-title":"Analysis of chromosome 1 microsatellite markers and the FHM2-ATP1A2 gene mutations in migraine pedigrees","volume":"27","author":"Curtain","year":"2005","journal-title":"Neurol Res"},{"key":"R38-12-20210206","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ajmg.b.30566","article-title":"No association of migraine to the GABA-A receptor complex on chromosome 15","volume":"147","author":"Oswell","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"R39-12-20210206","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/ajmg.b.30560","article-title":"Genetic association studies of the chromosome 15 GABA-A receptor cluster in migraine with aura","volume":"147","author":"Netzer","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"R40-12-20210206","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1086\/427521","article-title":"A new susceptibility locus for migraine with aura in the 15q11-q13 genomic region containing three GABA-A receptor genes","volume":"76","author":"Russo","year":"2005","journal-title":"Am J Hum Genet"},{"key":"R41-12-20210206","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/01.wco.0000169750.52406.a2","article-title":"Comorbidity of migraine","volume":"18","author":"Scher","year":"2005","journal-title":"Curr Opin Neurol"},{"key":"R42-12-20210206","first-page":"105","article-title":"A review of the genetic relation between migraine and epilepsy","volume":"28","author":"Haan","year":"2008","journal-title":"Cephalgia"},{"key":"R43-12-20210206","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1212\/01.wnl.0000262764.78511.17","article-title":"Familial occipitotemporal lobe epilepsy and migraine with visual aura: linkage to chromosome 9q","volume":"68","author":"Deprez","year":"2007","journal-title":"Neurology"},{"key":"R44-12-20210206","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/ana.410440506","article-title":"The phenotypic spectrum of CADASIL: clinical findings in 102 cases","volume":"44","author":"Dichgans","year":"1998","journal-title":"Ann Neurol"},{"key":"R45-12-20210206","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1750-3639.2002.tb00451.x","article-title":"CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia","volume":"2","author":"Kalimo","year":"2002","journal-title":"Brain Pathol"},{"key":"R46-12-20210206","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1212\/01.wnl.0000295994.46586.e7","article-title":"Clinical and brain MRI follow-up study of a family with COL4A1 mutation","volume":"69","author":"Vahedi","year":"2007","journal-title":"Neurology"},{"key":"R47-12-20210206","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/ng2082","article-title":"Truncations in the carboxyl-terminus of human 3\u2032\u20135\u2032 DNA exonuclease TREX1 cause retinal vasculopathy with cerebral leukodystrophy","volume":"39","author":"Richard","year":"2007","journal-title":"Nat Genet"},{"key":"R48-12-20210206","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/brain\/121.2.303","article-title":"Clinical and genetic analysis of a large Dutch family with autosomal dominant vascular retinopathy, migraine and Raynaud's phenomenon","volume":"121","author":"Terwindt","year":"1998","journal-title":"Brain"},{"key":"R49-12-20210206","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/j.1468-2982.2005.00994.x","article-title":"The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine","volume":"25","author":"Hottenga","year":"2005","journal-title":"Cephalalgia"},{"key":"R50-12-20210206","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2006.06.005","article-title":"The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death","volume":"23","author":"Chowdhury","year":"2006","journal-title":"Mol Cell"},{"key":"R51-12-20210206","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/ng1845","article-title":"Mutations in the gene encoding the 3\u2032-5\u2032 DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus","volume":"38","author":"Crow","year":"2006","journal-title":"Nat Genet"},{"key":"R52-12-20210206","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00109-007-0199-9","article-title":"A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus","volume":"85","author":"Lee-Kirsch","year":"2007","journal-title":"J Mol Med"},{"key":"R53-12-20210206","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1086\/513443","article-title":"Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome","volume":"80","author":"Rice","year":"2007","journal-title":"Am J Hum Genet"},{"key":"R54-12-20210206","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/ng2091","article-title":"Mutations in the gene encoding the 3\u2032-5\u2032 DNA exonuclease TREX1 are associated with systemic lupus erythematosus","volume":"39","author":"Lee-Kirsch","year":"2007","journal-title":"Nat Genet"},{"key":"R55-12-20210206","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1212\/01.wnl.0000265415.18382.fb","article-title":"Migraine as a systemic disorder","volume":"68","author":"Tietjen","year":"2007","journal-title":"Neurology"}],"container-title":["Current Opinion in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/WCO.0b013e3282fd171a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T17:50:16Z","timestamp":1708883416000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00019052-200806000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/wco.0b013e3282fd171a","relation":{},"ISSN":["1350-7540"],"issn-type":[{"value":"1350-7540","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}