{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:15:10Z","timestamp":1786119310095,"version":"build-2736575974"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1097\/wco.0b013e32832fd563","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T03:15:29Z","timestamp":1252984529000},"page":"480-485","source":"Crossref","is-referenced-by-count":46,"title":["Monoclonal gammopathy and neuropathy"],"prefix":"10.1097","volume":"22","author":[{"given":"Sindhu","family":"Ramchandren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210206","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1001\/archneur.1963.00460110102011","article-title":"Neurologic complications of myelomatosis","volume":"9","author":"Silverstein","year":"1963","journal-title":"Arch Neurol"},{"key":"R2-6-20210206","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1001\/archneur.1971.00490050038003","article-title":"The neuropathy of multiple myeloma: an electrophysiological and histological study","volume":"25","author":"Walsh","year":"1971","journal-title":"Arch Neurol"},{"key":"R3-6-20210206","first-page":"14","article-title":"Peripheral neuropathies associated with monoclonal gammopathies of undetermined significance","volume":"5","author":"Kelly","year":"2008","journal-title":"Rev Neurol Dis"},{"key":"R4-6-20210206","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/hon.845","article-title":"Review of peripheral neuropathy in plasma cell disorders","volume":"26","author":"Silberman","year":"2008","journal-title":"Hematol Oncol"},{"key":"R5-6-20210206","first-page":"67","article-title":"Dysimmune neuropathy","author":"Kwan","year":"2009"},{"key":"R6-6-20210206","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.0954-6820.1966.tb05453.x","article-title":"Frequency of pathological proteins (M-components) in 6,995 sera from an adult population","volume":"179","author":"Axelsson","year":"1966","journal-title":"Acta Med Scand"},{"key":"R7-6-20210206","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/jcp.35.1.63","article-title":"Monoclonal gammopathies in the adult population of Finistere, France","volume":"35","author":"Saleun","year":"1982","journal-title":"J Clin Pathol"},{"key":"R8-6-20210206","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1212\/WNL.31.11.1480","article-title":"Prevalence of monoclonal protein in peripheral neuropathy","volume":"31","author":"Kelly","year":"1981","journal-title":"Neurology"},{"key":"R9-6-20210206","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1002\/ana.410370705","article-title":"Pathogenesis and therapy of neuropathies associated with monoclonal gammopathies","volume":"37","author":"Latov","year":"1995","journal-title":"Ann Neurol"},{"key":"R10-6-20210206","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1056\/NEJM199212313272705","article-title":"Plasma cell dyscrasia with polyneuropathy: the spectrum of POEMS syndrome","volume":"327","author":"Miralles","year":"1992","journal-title":"N Engl J Med"},{"key":"R12-6-20210206","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1600-0404.1992.tb06033.x","article-title":"Peripheral neuropathy in monoclonal gammopathy of unknown significance: prevalence and immunopathogenetic studies","volume":"85","author":"Nobile-Orazio","year":"1992","journal-title":"Acta Neurol Scand"},{"key":"R13-6-20210206","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0022-510X(93)90297-C","article-title":"Clinical, neurophysiological, and immunological evidence of polyneuropathy in patients with monoclonal gammopathies","volume":"114","author":"Vrethem","year":"1993","journal-title":"J Neurol Sci"},{"key":"R14-6-20210206","first-page":"45","article-title":"Primary systemic amyloidosis: clinical and laboratory features in 474 cases","volume":"32","author":"Kyle","year":"1995","journal-title":"Semin Hematol"},{"key":"R15-6-20210206","first-page":"665","article-title":"Amyloidosis (AL): clinical and laboratory features in 229 cases","volume":"58","author":"Kyle","year":"1983","journal-title":"Mayo Clin Proc"},{"key":"R16-6-20210206","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1182\/blood.V83.6.1452.1452","article-title":"Waldenstrom's macroglobulinemia","volume":"83","author":"Dimopolous","year":"1994","journal-title":"Blood"},{"key":"R18-6-20210206","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1001\/jama.1984.03340380031018","article-title":"\u2018Benign\u2019 monoclonal gammopathy: a misnomer?","volume":"251","author":"Kyle","year":"1984","journal-title":"J Am Med Assoc"},{"key":"R19-6-20210206","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1212\/01.WNL.0000176296.79088.9A","article-title":"Malignant transformation in polyneuropathy associated with monoclonal gammopathy","volume":"64","author":"Eurelings","year":"2005","journal-title":"Neurology"},{"issue":"s2","key":"R20-6-20210206","first-page":"62","article-title":"Paraproteinemia related neuropathies","volume":"92","author":"Nobile-Orazio","year":"2007","journal-title":"Haematologica"},{"key":"R21-6-20210206","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/ana.410360313","article-title":"Frequency and clinical correlates of antineural IgM antibodies in neuropathy associated with IgM monoclonal gammopathy","volume":"36","author":"Nobile-Orazio","year":"1994","journal-title":"Ann Neurol"},{"key":"R22-6-20210206","first-page":"301","article-title":"Peripheral neuropathy and anti-MAG antibodies","volume":"3","author":"Latov","year":"1988","journal-title":"CRC Crit Rev Neurobiol"},{"key":"R23-6-20210206","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/BF00878529","article-title":"Neuropathy associated with \u2018benign\u2019 antimyelin-associated glycoprotein IgM gammopathy: clinical, immunological, neurophysiological and pathological findings and response to treatment in 33 cases","volume":"243","author":"Ellis","year":"1996","journal-title":"J Neurol"},{"key":"R24-6-20210206","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/ana.410330514","article-title":"Experimental paraprotein neuropathy, demyelination by passive transfer of human IgM antimyelin-associated glycoprotein","volume":"33","author":"Tatum","year":"1993","journal-title":"Ann Neurol"},{"key":"R25-6-20210206","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1212\/WNL.47.5.1227","article-title":"Intermittent cyclophosphamide and prednisone treatment of polyneuropathy associated with monoclonal gammopathy of undetermined significance","volume":"47","author":"Notermans","year":"1996","journal-title":"Neurology"},{"key":"R26-6-20210206","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1098-1101(1999)14:3<149::AID-JCA8>3.0.CO;2-9","article-title":"Clinical features, evaluation and treatment of patients with polyneuropathy associated with monoclonal gammopathy of undetermined significance (MGUS)","volume":"14","author":"Gorson","year":"1999","journal-title":"J Clin Apher"},{"key":"R27-6-20210206","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0022-510X(99)00049-0","article-title":"Clinical features and antineural reactivity in neuropathy associated with IgG monoclonal gammopathy of undetermined significance","volume":"164","author":"Di Troia","year":"1999","journal-title":"J Neurol Sci"},{"key":"R28-6-20210206","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1440-1789.2008.00875.x","article-title":"Presence of crystalline inclusions in the peripheral nerve of a patient with IgA lambda monoclonal gammopathy of undetermined significance","volume":"28","author":"Vital","year":"2008","journal-title":"Neuropathology"},{"key":"R29-6-20210206","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.micron.2006.12.005","article-title":"Contribution of electron microscopy to the study of neuropathies associated with an IgG monoclonal paraproteinemia","volume":"39","author":"Vallat","year":"2008","journal-title":"Micron"},{"key":"R30-6-20210206","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/brain\/123.4.710","article-title":"Long term prognosis of neuropathy associated with anti-MAG IgM M proteins and its relation with immune therapies","volume":"123","author":"Nobile-Orazio","year":"2000","journal-title":"Brain"},{"key":"R31-6-20210206","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/1097-4598(200103)24:3<311::AID-MUS1001>3.0.CO;2-A","article-title":"Clinical spectrum of chronic acquired demyelinating polyneuropathies","volume":"24","author":"Saperstein","year":"2001","journal-title":"Muscle Nerve"},{"key":"R32-6-20210206","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/brain\/117.5.941","article-title":"Distal accentuation of conduction slowing in polyneuropathy associated with antibodies to myelin-associated glycoprotein and sulphated glucuronyl paragloboside","volume":"117","author":"Kaku","year":"1994","journal-title":"Brain"},{"key":"R33-6-20210206","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/mus.880160113","article-title":"Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance","volume":"16","author":"Simmons","year":"1993","journal-title":"Muscle Nerve"},{"key":"R34-6-20210206","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1046\/j.1468-1331.2003.00687.x","article-title":"Polyneuropathy associated with IgG\/IgA monoclonal gammopathy: a clinical and electrophysiological study of 15 cases","volume":"10","author":"Magy","year":"2003","journal-title":"Eur J Neurol"},{"key":"R35-6-20210206","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s00277-001-0420-9","article-title":"IgM myeloma: a report of four cases","volume":"81","author":"Dierlamm","year":"2002","journal-title":"Ann Hematol"},{"key":"R36-6-20210206","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00005792-198007000-00006","article-title":"Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes: the POEMS syndrome; report on two cases and a review of the literature","volume":"59","author":"Bardwick","year":"1980","journal-title":"Medicine"},{"key":"R37-6-20210206","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1750-3639.2001.tb00407.x","article-title":"Paraproteinemic neuropathies","volume":"11","author":"Vital","year":"2001","journal-title":"Brain Pathol"},{"key":"R38-6-20210206","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1182\/blood.V87.4.1458.bloodjournal8741458","article-title":"Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome","volume":"87","author":"Gherardi","year":"1996","journal-title":"Blood"},{"key":"R39-6-20210206","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1093\/brain\/124.10.1968","article-title":"The clinical and laboratory features of chronic sensory ataxic neuropathy with antidisialosyl IgM antibodies","volume":"124","author":"Willison","year":"2001","journal-title":"Brain"},{"key":"R40-6-20210206","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1085-9489.2006.00059.x","article-title":"European Federation of Neurological Societies\/Peripheral Nerve Society Guideline on management of paraproteinemic demyelinating neuropathies. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society.","volume":"11","year":"2006","journal-title":"J Peripher Nerv Syst"},{"key":"R41-6-20210206","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0022-510X(99)00317-2","article-title":"The spectrum of chronic inflammatory demyelinating polyneuropathy","volume":"173","author":"Rotta","year":"2000","journal-title":"J Neurol Sci"},{"key":"R42-6-20210206","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1212\/WNL.54.3.615","article-title":"Distal acquired demyelinating symmetric neuropathy","volume":"54","author":"Katz","year":"2000","journal-title":"Neurology"},{"key":"R43-6-20210206","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1056\/NEJM199111213252105","article-title":"Plasma exchange in polyneuropathy associated with monoclonal gammopathy of undetermined significance","volume":"325","author":"Dyck","year":"1991","journal-title":"N Engl J Med"},{"key":"R44-6-20210206","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/jnnp.59.3.243","article-title":"Plasma exchange and chlorambucil in polyneuropathy associated with monoclonal IgM gammopathy. IgM-associated polyneuropathy study group","volume":"59","author":"Oksenhendler","year":"1995","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R45-6-20210206","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/ana.410230415","article-title":"Plasmapheresis alleviated neuropathy accompanying IgM antimyelin associated glycoprotein paraproteinemia","volume":"23","author":"Haas","year":"1988","journal-title":"Ann Neurol"},{"key":"R46-6-20210206","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/mus.1069","article-title":"Treatment experience in patients with antimyelin-associated glycoprotein neuropathy","volume":"24","author":"Gorson","year":"2001","journal-title":"Muscle Nerve"},{"key":"R47-6-20210206","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/jnnp.66.5.575","article-title":"Successful treatment of IgM paraproteinemia with fludarabine","volume":"66","author":"Wilson","year":"1999","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R48-6-20210206","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/ana.410400516","article-title":"A controlled study of intravenous immunoglobulin in demyelinating neuropathy with IgM gammopathy","volume":"40","author":"Dalakas","year":"1996","journal-title":"Ann Neurol"},{"issue":"S2","key":"R50-6-20210206","first-page":"A551","article-title":"Therapy of neuropathy associated with anti-MAG IgM monoclonal gammopathy with rituxan","volume":"52","author":"Latov","year":"1999","journal-title":"Neurology"},{"key":"R51-6-20210206","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1212\/WNL.52.8.1701","article-title":"IgM antibody-related polyneuropathies: B cell depletion chemotherapy using rituximab","volume":"52","author":"Levine","year":"1999","journal-title":"Neurology"},{"key":"R52-6-20210206","first-page":"78","article-title":"Chronic peripheral neuropathy responsive to rituximab","volume":"3","author":"Kelly","year":"2006","journal-title":"Rev Neurol Dis"},{"key":"R53-6-20210206","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1529-8027.2007.00129.x","article-title":"Predictors of response to rituximab in patients with neuropathy and antimyelin associated glycoprotein immunoglobulin M","volume":"12","author":"Benedetti","year":"2007","journal-title":"J Peripher Nerv Syst"},{"key":"R54-6-20210206","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/ana.21577","article-title":"Placebo-controlled trial of rituximab in IgM antimyelin-associated glycoprotein antibody demyelinating neuropathy","volume":"65","author":"Dalakas","year":"2009","journal-title":"Ann Neurol"},{"key":"R55-6-20210206","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1212\/01.wnl.0000335268.70325.33","article-title":"Long-term effect of rituximab in anti-MAG polyneuropathy","volume":"71","author":"Benedetti","year":"2008","journal-title":"Neurology"},{"issue":"Suppl 1","key":"R56-6-20210206","first-page":"A491","article-title":"Rituximab is effective for some patients with IgM kappa related polyneuropathy: a report of results in 8 patients","volume":"60","author":"Lewis","year":"2003","journal-title":"Neurology"},{"key":"R57-6-20210206","first-page":"A175","article-title":"Long term efficacy of rituximab for IgM and anti-MAG neuropathy","volume":"13","author":"Lewis","year":"2008","journal-title":"J Peripher Nerv Syst"}],"container-title":["Current Opinion in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/WCO.0b013e32832fd563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:57:48Z","timestamp":1786039068000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00019052-200910000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/wco.0b013e32832fd563","relation":{},"ISSN":["1350-7540"],"issn-type":[{"value":"1350-7540","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}