{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:33:39Z","timestamp":1777440819442,"version":"3.51.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Whipple disease is a rare, chronic multisystem infectious disease. The central nervous system (CNS) is secondarily involved in 43% of patients; 5% of patients have isolated or primary CNS involvement. The most frequent CNS symptoms are cognitive changes. Prosopagnosia is an inability to recognize familiar faces, in a person who does not have vision impairments or cognitive alterations. This relatively rare condition is usually related to vascular, traumatic, degenerative, or infectious lesions. We report a 54-year-old woman who presented subacutely with fever, headache, and seizures that led to a diagnosis of infectious meningoencephalitis. She improved temporarily on broad-spectrum antibiotics, but then developed a chronically evolving cognitive impairment with associative prosopagnosia as the major complaint. She had a history of sporadic abdominal pain and mild sacroiliac arthralgia. After a negative duodenal biopsy, we confirmed primary CNS Whipple disease by polymerase chain reaction and brain biopsy. We treated the patient with ceftriaxone for 15 days and then co-trimoxazole for 2 years. At 8-year follow-up, she had no further impairments, but continuing prosopagnosia. To our knowledge, this is the first description of isolated prosopagnosia in a patient with primary CNS Whipple disease. Because CNS Whipple disease can lead to serious, irreversible lesions if not promptly treated, clinicians must suspect the diagnosis, treat with long-term antibiotics, and follow patients carefully to prevent recurrence.<\/jats:p>","DOI":"10.1097\/wnn.0000000000000091","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T22:41:38Z","timestamp":1466721698000},"page":"100-106","source":"Crossref","is-referenced-by-count":7,"title":["Prosopagnosia as the Presenting Symptom of Whipple Disease"],"prefix":"10.1097","volume":"29","author":[{"given":"Miguel","family":"T\u00e1buas-Pereira","sequence":"first","affiliation":[{"name":"Neurology Department and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarida","family":"Vicente","sequence":"additional","affiliation":[{"name":"Neurology Department 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