{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:23:11Z","timestamp":1770978191004,"version":"3.50.1"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>In patients with bilateral sequential nonarteritic anterior ischemic optic neuropathy (NA-AION), previous studies have reported conflicting results on whether or not the visual outcome is similar in the 2 eyes. The authors investigated this issue in 174 consecutive patients with bilateral NA-AION.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>At the first visit, all patients had a detailed ophthalmic and medical history and comprehensive ophthalmic evaluation. Visual evaluation was performed by recording Snellen visual acuity and visual fields with kinetic perimetry. The same ophthalmic evaluation was performed at each follow-up visit. The data on the difference in visual acuity, which was converted to logarithm of the minimum angle of resolution (logMAR) form, and visual field defects between the first eye and the second eye of each patient at the initial visit and at the final follow-up were analyzed. A similar subgroup analysis was performed on patients treated with systemic corticosteroids.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>At presentation, both initial visual acuity and visual field defects were significantly better in the second eye than in the first eye (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.0001). As a predictor of initial visual acuity in the second eye, the initial logMAR of the first eye only explained 7.0% (R<jats:sup>2<\/jats:sup>) of the total variation in the initial logMAR of the second eye. Intraclass correlation (ICC) between the paired eyes was 0.19 (95% confidence interval [CI], 0.04\u20130.33), indicating poor agreement. The absolute difference in initial visual field grade between the 2 eyes was 0.5 or greater in 78%. The weighted kappa statistic for agreement between visual field defects of the 2 eyes was 0.27 (95% CI, 0.19\u20130.36), indicating poor agreement. At the final follow-up, a difference in logMAR of at least 0.3 between the paired eyes was found in 38% of the steroid-treated group and 45% of the untreated group. For visual field grade, there was a difference of at least 0.5 in 70% of those who were treated with steroid and in 76% of those not treated. The ICC for logMAR and weighted kappa for visual field grade for the paired eyes was below 0.60 for both the groups. The findings indicated poor agreement between the 2 eyes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>The results show that in patients with bilateral sequential NA-AION, there are large differences between the visual acuity and visual field findings of paired eyes at initial and final visit, whether or not treated with steroids. It is not possible to predict the visual acuity and visual field grade in the second eye based solely on the first eye.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/wno.0b013e31829b5d03","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T13:44:51Z","timestamp":1373377491000},"page":"338-343","source":"Crossref","is-referenced-by-count":10,"title":["Bilateral Nonarteritic Anterior Ischemic Optic Neuropathy"],"prefix":"10.1097","volume":"33","author":[{"given":"Sohan Singh","family":"Hayreh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Bridget","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-4-20240116","first-page":"506","article-title":"Study of numerous cases of vascular pseudopapilitis in French.","volume":"79","author":"Georgiades","year":"1966","journal-title":"Bull Mem Soc Fr Ophthalmol"},{"key":"R2-4-20240116","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/brain\/98.4.689","article-title":"Ischaemic optic neuropathy: the clinical profile and history.","volume":"98","author":"Boghen","year":"1975","journal-title":"Brain"},{"key":"R3-4-20240116","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/00041327-199712000-00007","article-title":"Aspirin reduces the incidence of second eye NAION: a retrospective study.","volume":"17","author":"Kupersmith","year":"1997","journal-title":"J Neuroophthalmol"},{"key":"R4-4-20240116","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0161-6420(97)30354-6","article-title":"Comparison of visual function in fellow eyes after bilateral nonarteritic anterior ischemic optic neuropathy.","volume":"104","author":"WuDunn","year":"1997","journal-title":"Ophthalmology"},{"key":"R5-4-20240116","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0002-9394(02)01639-2","article-title":"The fellow eye in NAION.","volume":"134","author":"Newman","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"R6-4-20240116","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/BF00944015","article-title":"Vascular opticopathy.","volume":"26","author":"Kurz","year":"1969","journal-title":"Doc Ophthalmol"},{"key":"R7-4-20240116","first-page":"46","article-title":"Anterior ischemic optic neuropathy and aging.","volume":"12","author":"Moro","year":"1989","journal-title":"Metab Pediatr Syst Ophthalmol"},{"key":"R8-4-20240116","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0161-6420(96)30519-8","article-title":"Visual outcome in bilateral nonarteritic anterior ischemic optic neuropathy.","volume":"103","author":"Boone","year":"1996","journal-title":"Ophthalmology"},{"key":"R9-4-20240116","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/archophthalmol.2012.581","article-title":"Bilateral sequential nonarteritic anterior ischemic optic neuropathya comparison of visual outcomes in fellow eyes using quantitative analysis of Goldmann visual fields.","volume":"130","author":"Mercado","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"R10-4-20240116","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1001\/jama.1995.03520320035038","article-title":"Optic nerve decompression surgery for nonarteritic anterior ischemic optic neuropathy (NAION) is not effective and may be harmful.","volume":"273","year":"1995","journal-title":"JAMA"},{"key":"R11-4-20240116","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ophtha.2007.05.027","article-title":"Non-arteritic anterior ischemic optic neuropathynatural history of visual outcome.","volume":"115","author":"Hayreh","year":"2008","journal-title":"Ophthalmology"},{"key":"R12-4-20240116","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00417-008-0805-8","article-title":"Non-arteritic anterior ischemic optic neuropathy: role of systemic corticosteroid therapy.","volume":"246","author":"Hayreh","year":"2008","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R13-4-20240116","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.ophtha.2006.11.035","article-title":"Incipient non-arteritic anterior ischemic optic neuropathy.","volume":"114","author":"Hayreh","year":"2007","journal-title":"Ophthalmology"},{"key":"R14-4-20240116","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s00417-006-0494-0","article-title":"Optic disc edema in non-arteritic anterior ischemic optic neuropathy.","volume":"245","author":"Hayreh","year":"2007","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R15-4-20240116","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1037\/0033-2909.86.2.420","article-title":"Intraclass correlations: uses in assessing rater reliability.","volume":"86","author":"Shrout","year":"1979","journal-title":"Psychol Bull"},{"key":"R16-4-20240116","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data.","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"R18-4-20240116","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1001\/archopht.1968.03850040402007","article-title":"Grid for scoring visual fields. II. Perimeter.","volume":"79","author":"Esterman","year":"1968","journal-title":"Arch Ophthalmol"}],"container-title":["Journal of Neuro-Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00041327-201312000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T19:20:32Z","timestamp":1705432832000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00041327-201312000-00004"}},"subtitle":["Comparison of Visual Outcome in the Two Eyes"],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/wno.0b013e31829b5d03","relation":{},"ISSN":["1070-8022"],"issn-type":[{"value":"1070-8022","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}