{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:12:57Z","timestamp":1786119177815,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,8]]},"DOI":"10.1097\/wnr.0b013e3282f3b0ec","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T22:36:59Z","timestamp":1236206219000},"page":"117-120","source":"Crossref","is-referenced-by-count":24,"title":["Taurine attenuates aminoglycoside ototoxicity by inhibiting inducible nitric oxide synthase expression in the cochlea"],"prefix":"10.1097","volume":"19","author":[{"given":"Hai-ying","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-lu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-yuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-22-20210201","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00019052-200202000-00003","article-title":"Nitric oxide in the inner ear","volume":"15","author":"Takumida","year":"2002","journal-title":"Curr Opin Neurol"},{"key":"R2-22-20210201","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-5955(99)00188-4","article-title":"Lipopolysaccharide-induced expression of inducible nitric oxide synthase in the guinea pig organ of Corti","volume":"140","author":"Takumida","year":"2000","journal-title":"Hear Res"},{"key":"R3-22-20210201","first-page":"63","article-title":"Free radicals in the guinea pig inner ear following gentamicin exposure","volume":"61","author":"Takumida","year":"1999","journal-title":"J Otorhinolaryngol"},{"key":"R4-22-20210201","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00001813-200001000-00005","article-title":"Expression of inducible nitric oxide synthase (iNOS\/NOS II) in the vestibule of guinea pigs after the application of cisplatin","volume":"11","author":"Watanabe","year":"2000","journal-title":"Anticancer Drugs"},{"key":"R5-22-20210201","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00020840-200310000-00004","article-title":"Ototoxicity: bioprotective mechanisms","volume":"11","author":"Rybak","year":"2003","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"R6-22-20210201","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.heares.2005.08.009","article-title":"Gentamicin induced nitric oxide-related oxidative damages on vestibular afferents in the guinea pig","volume":"211","author":"Hong","year":"2006","journal-title":"Hear Res"},{"key":"R7-22-20210201","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0165-5876(03)00035-1","article-title":"Effect of round window membrane application of nitric oxide on hearing and nitric oxide concentration in perilymph","volume":"67","author":"Hanson","year":"2003","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"R8-22-20210201","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0378-5955(93)90214-L","article-title":"Cellular localisation of taurine in the organ of Corti","volume":"65","author":"Harding","year":"1993","journal-title":"Hear Res"},{"key":"R9-22-20210201","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.brainres.2005.01.058","article-title":"Mode of action of taurine as a neuroprotector","volume":"1038","author":"Wu","year":"2005","journal-title":"Brain Res"},{"key":"R10-22-20210201","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-1-4615-0077-3_39","article-title":"Why is taurine cytoprotective?","volume":"526","author":"Schaffer","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"R11-22-20210201","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1006\/niox.2000.0297","article-title":"Suppression of bleomycin-induced nitric oxide production in mice by taurine and niacin","volume":"4","author":"Gurujeyalakshmi","year":"2000","journal-title":"Nitric Oxide"},{"key":"R12-22-20210201","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.4049\/jimmunol.167.4.2275","article-title":"Taurine chloramine inhibits inducible nitric oxide synthase and TNF-alpha gene expression in activated alveolar macrophages: decreased NF-kappaB activation and IkappaB kinase activity","volume":"167","author":"Barua","year":"2001","journal-title":"J Immunol"},{"key":"R13-22-20210201","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neulet.2006.01.070","article-title":"Taurine modulates calcium influx through L-type voltage-gated calcium channels in isolated cochlear outer hair cells in guinea pigs","volume":"399","author":"Liu","year":"2006","journal-title":"Neurosci Lett"},{"key":"R14-22-20210201","first-page":"12","article-title":"The effect of single combined administration of gentamycin and furosemide on auditory brainstem responses and succinate dehydrogenase activity in guinea pigs","volume":"6","author":"Liu","year":"2006","journal-title":"Chin J Ophthalmol and Otorhinolaryngol"},{"key":"R15-22-20210201","first-page":"189","article-title":"Handbook of mouse auditory research.","author":"Ding","year":"2001"},{"key":"R16-22-20210201","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0378-5955(02)00796-7","article-title":"Altered expression of inducible nitric oxide synthase (iNOS) in the cochlea","volume":"177","author":"Shi","year":"2003","journal-title":"Hear Res"},{"key":"R17-22-20210201","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/03005364000000050","article-title":"The effect of gentamicin and furosemide given in combination on cochlear potentials in the guinea pig","volume":"32","author":"Mulheran","year":"1998","journal-title":"Br J Audiol"},{"key":"R18-22-20210201","first-page":"3","article-title":"Aminoglycoside antibiotics","volume":"5","author":"Forge","year":"2000","journal-title":"Audiol"},{"issue":"Suppl","key":"R19-22-20210201","doi-asserted-by":"crossref","first-page":"s28","DOI":"10.3109\/00016488809102854","article-title":"Furosemide-induced alteration of drug pathway to cochlea","volume":"447","author":"Yamane","year":"1988","journal-title":"Acta Otolaryngol"},{"key":"R20-22-20210201","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0378-5955(01)00315-X","article-title":"Ischemia-reperfusion injury of the cochlea: effects of an iron chelator and nitric oxide synthase inhibitors","volume":"160","author":"Tabuchi","year":"2001","journal-title":"Hear Res"},{"key":"R21-22-20210201","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s004050050071","article-title":"Taurine entry into perilymph of the guinea pig","volume":"255","author":"Angelini","year":"1998","journal-title":"Eur Arch Otorhinolaryngol"}],"container-title":["NeuroReport"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/WNR.0b013e3282f3b0ec","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:40:42Z","timestamp":1786038042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001756-200801080-00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,8]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/wnr.0b013e3282f3b0ec","relation":{},"ISSN":["0959-4965"],"issn-type":[{"value":"0959-4965","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1,8]]}}}