{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:15:23Z","timestamp":1791112523180,"version":"4.1.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,5]]},"DOI":"10.1097\/wnr.0b013e32832e34ee","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T03:23:16Z","timestamp":1247109796000},"page":"1098-1103","source":"Crossref","is-referenced-by-count":192,"title":["Distinct neuroinflammatory profile in post-mortem human Huntington's disease"],"prefix":"10.1097","volume":"20","author":[{"given":"Aurelio","family":"Silvestroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.M.","family":"Faull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Strand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20210201","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1055\/s-2007-971176","article-title":"Huntington's disease","volume":"27","author":"Walker","year":"2007","journal-title":"Semin Neurol"},{"key":"R2-12-20210201","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nrn1806","article-title":"Normal huntingtin function: an alternative approach to Huntington's disease","volume":"6","author":"Cattaneo","year":"2005","journal-title":"Nat Rev"},{"key":"R3-12-20210201","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J Neuropathol Exp Neurol"},{"key":"R4-12-20210201","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.it.2008.05.002","article-title":"Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression","volume":"29","author":"Gao","year":"2008","journal-title":"Trends Immunol"},{"key":"R5-12-20210201","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1006\/exnr.1999.7170","article-title":"Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease","volume":"159","author":"Singhrao","year":"1999","journal-title":"Exp Neurol"},{"key":"R6-12-20210201","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/jnen\/60.2.161","article-title":"Early and progressive accumulation of reactive microglia in the Huntington disease brain","volume":"60","author":"Sapp","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"R7-12-20210201","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/77528","article-title":"Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease","volume":"6","author":"Chen","year":"2000","journal-title":"Nat Med"},{"key":"R8-12-20210201","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/20446","article-title":"Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease","volume":"399","author":"Ona","year":"1999","journal-title":"Nature"},{"key":"R9-12-20210201","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1212\/01.wnl.0000222734.56412.17","article-title":"Microglial activation correlates with severity in Huntington disease: a clinical and PET study","volume":"66","author":"Pavese","year":"2006","journal-title":"Neurology"},{"key":"R10-12-20210201","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1084\/jem.20080178","article-title":"A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease","volume":"205","author":"Bj\u00f6rkqvist","year":"2008","journal-title":"J Exp Med"},{"key":"R11-12-20210201","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington's disease brain","volume":"15","author":"Hodges","year":"2006","journal-title":"Hum Mol Genet"},{"key":"R12-12-20210201","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/hmg\/ddm133","article-title":"Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage","volume":"16","author":"Kuhn","year":"2007","journal-title":"Hum Mol Genet"},{"key":"R13-12-20210201","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jneumeth.2007.06.001","article-title":"Quality control for microarray analysis of human brain samples: the impact of postmortem factors, RNA characteristics, and histopathology","volume":"165","author":"Weis","year":"2007","journal-title":"J Neurosci Methods"},{"key":"R14-12-20210201","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"R15-12-20210201","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0896-6273(02)00794-8","article-title":"Inflammation in neurodegenerative disease \u2013 a double-edged sword","volume":"35","author":"Wyss-Coray","year":"2002","journal-title":"Neuron"},{"key":"R16-12-20210201","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/glia.10161","article-title":"Microglia as a source and target of cytokines","volume":"40","author":"Hanisch","year":"2002","journal-title":"Glia"},{"key":"R17-12-20210201","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1002\/glia.20552","article-title":"Spatial arrangement of microglia in the mouse hippocampus: a stereological study in comparison with astrocytes","volume":"55","author":"Jinno","year":"2007","journal-title":"Glia"},{"key":"R18-12-20210201","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/nbt1236","article-title":"Evaluation of DNA microarray results with quantitative gene expression platforms","volume":"24","author":"Canales","year":"2006","journal-title":"Nat Biotechnol"},{"key":"R19-12-20210201","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tig.2005.12.005","article-title":"Reliability and reproducibility issues in DNA microarray measurements","volume":"22","author":"Draghici","year":"2006","journal-title":"Trends Genet"},{"key":"R20-12-20210201","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/nn1988","article-title":"Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease","volume":"10","author":"Lobsiger","year":"2007","journal-title":"Nat Neurosci"},{"key":"R21-12-20210201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jir.2005.25.1","article-title":"The AU-rich transcriptome: more than interferons and cytokines, and its role in disease","volume":"25","author":"Khabar","year":"2005","journal-title":"J Interferon Cytokine Res"},{"key":"R22-12-20210201","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cytogfr.2008.05.001","article-title":"The TNF superfamily-2008","volume":"19","author":"Ware","year":"2008","journal-title":"Cytokine Growth Factor Rev"},{"key":"R23-12-20210201","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.pneurobio.2007.03.004","article-title":"Transcriptional signatures in Huntington's disease","volume":"83","author":"Cha","year":"2007","journal-title":"Prog Neurobiol"},{"key":"R24-12-20210201","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"R25-12-20210201","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/brain\/awm044","article-title":"Microglial activation in presymptomatic Huntington's disease gene carriers","volume":"130","author":"Tai","year":"2007","journal-title":"Brain"}],"container-title":["NeuroReport"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00001756-200908050-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T22:04:37Z","timestamp":1618265077000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00001756-200908050-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,5]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/wnr.0b013e32832e34ee","relation":{},"ISSN":["0959-4965"],"issn-type":[{"value":"0959-4965","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8,5]]}}}