{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:17:24Z","timestamp":1786119444377,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,2]]},"DOI":"10.1097\/wnr.0b013e3283373126","type":"journal-article","created":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T02:45:16Z","timestamp":1272941116000},"page":"543-548","source":"Crossref","is-referenced-by-count":16,"title":["L-methionine decreases dendritic spine density in mouse frontal cortex"],"prefix":"10.1097","volume":"21","author":[{"given":"Patricia","family":"Tueting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marin","family":"Veldic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pibiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashkim","family":"Kadriu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Guidotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erminio","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-1-20210201","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/archpsyc.57.1.65","article-title":"Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia","volume":"57","author":"Glanz","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"R2-1-20210201","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archpsyc.57.11.1061","article-title":"Decreased reelin and glutamic acid decarboxylase 67 (GAD67) expression in schizophrenia and bipolar disorders a postmortem brain study","volume":"57","author":"Guidotti","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"R3-1-20210201","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.mp.4001954","article-title":"Selective epigenetic alteration of layer 1 GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection","volume":"12","author":"Ruzicka","year":"2007","journal-title":"Mol Psychiatry"},{"key":"R4-1-20210201","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1073\/pnas.051614698","article-title":"Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse","volume":"98","author":"Liu","year":"2001","journal-title":"Proc Nat Acad Sci U S A"},{"key":"R5-1-20210201","first-page":"422","article-title":"The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene","volume":"1779","author":"Levenson","year":"2008","journal-title":"Biochem Biophys Acta"},{"key":"R6-1-20210201","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.neubiorev.2006.04.001","article-title":"Reelin down-regulation in mice and psychosis endophenotypes","volume":"30","author":"Tueting","year":"2006","journal-title":"Neurosci Biobehav Rev"},{"key":"R7-1-20210201","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4161\/epi.4.3.8534","article-title":"From trans-methylation to cytosine methylation: Evolution of the methylation hypothesis of schizophrenia","volume":"4","author":"Grayson","year":"2009","journal-title":"Epigenetics"},{"key":"R8-1-20210201","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.biopsych.2004.11.046","article-title":"Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice","volume":"57","author":"Tremolizzo","year":"2005","journal-title":"Biol Psychiatry"},{"key":"R10-1-20210201","doi-asserted-by":"crossref","first-page":"13614","DOI":"10.1073\/pnas.0805493105","article-title":"Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation","volume":"105","author":"Dong","year":"2008","journal-title":"Proc Nat Acad Sci U S A"},{"key":"R11-1-20210201","first-page":"387","article-title":"Dendritic organization in the neurons of the visual and motor cortices of the cat","volume":"87","author":"Sholl","year":"1953","journal-title":"J Anat"},{"key":"R12-1-20210201","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1001\/archpsyc.57.4.349","article-title":"Structural abnormalities of subicular dendrites in subjects with schizophrenia and mood disorders","volume":"57","author":"Rosoklija","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"R13-1-20210201","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/schbul\/sbm064","article-title":"Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanism","volume":"33","author":"Benes","year":"2007","journal-title":"Schizophrenia Bull"},{"key":"R14-1-20210201","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/sj.npp.1301563","article-title":"Neuroplasticity of neocortical circuits in schizophrenia","volume":"33","author":"Lewis","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"R15-1-20210201","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1073\/pnas.97.7.3550","article-title":"Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex","volume":"97","author":"Rodriguez","year":"2000","journal-title":"Proc Nat Acad Sci U S A"},{"key":"R16-1-20210201","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1006\/nbdi.2001.0436","article-title":"Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability","volume":"8","author":"Costa","year":"2001","journal-title":"Neurobiol Dis"},{"key":"R17-1-20210201","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1073\/pnas.0810764106","article-title":"The N-terminal region of reelin regulates postnatal dendritic maturation of cortical pyramidal neurons","volume":"106","author":"Chameau","year":"2009","journal-title":"Proc Nat Acad Sci U S A"},{"key":"R18-1-20210201","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1073\/pnas.1031602100","article-title":"A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes","volume":"100","author":"Dong","year":"2003","journal-title":"Proc Nat Acad Sci U S A"},{"key":"R19-1-20210201","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.biopsych.2005.01.010","article-title":"Analysis of pyramidal neuron morphology in an inducible knockout of brain-derived neurotrophic factor","volume":"57","author":"Hill","year":"2005","journal-title":"Biol Psychiatry"},{"key":"R20-1-20210201","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.schres.2007.11.030","article-title":"Increased truncated TrkB receptor expression and decreased BDNF\/TrkB signaling in the frontal cortex of reeler mouse model of schizophrenia","volume":"100","author":"Pillai","year":"2008","journal-title":"Schizophr Res"},{"key":"R21-1-20210201","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/carcin\/bgl167","article-title":"Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes","volume":"28","author":"Milutinovic","year":"2007","journal-title":"Carcinogenesis"},{"key":"R22-1-20210201","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tips.2008.10.010","article-title":"Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling","volume":"30","author":"Guidotti","year":"2009","journal-title":"Trends Pharm Sci"},{"key":"R23-1-20210201","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature07925","article-title":"HDAC2 negatively regulates memory formation and synaptic plasticity","volume":"459","author":"Guan","year":"2009","journal-title":"Nature"},{"key":"R24-1-20210201","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.schres.2009.03.002","article-title":"Chronic psychotropic drug treatment causes differential expression of reelin signaling system in freontal cortex of rats","volume":"111","author":"Fatemi","year":"2009","journal-title":"Schizophr Res"},{"key":"R25-1-20210201","doi-asserted-by":"crossref","first-page":"13479","DOI":"10.1073\/pnas.0702334104","article-title":"\u03b2-catenin regulates excitatory postsynaptic strength at hippocampal synapses","volume":"104","author":"Okuda","year":"2007","journal-title":"Proc Nat Acad Sci U S A"}],"container-title":["NeuroReport"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001756-201006020-00001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:19:03Z","timestamp":1786040343000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001756-201006020-00001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,2]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/wnr.0b013e3283373126","relation":{},"ISSN":["0959-4965"],"issn-type":[{"value":"0959-4965","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6,2]]}}}