{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:44:45Z","timestamp":1782981885227,"version":"3.54.5"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Peristomal pyoderma gangrenosum (PPG) is a variant of pyoderma gangrenosum (PG). It results from a pathergy response to trauma from effluent from the ostomy or secondary to trauma caused by removal of the ostomy appliance adhesive in contact with the skin. Currently, no evidence-based guidelines for the management of PPG exist. This case study reports a dramatic response to crushed corticosteroid tablets in a patient who proved refractory to first- and second-line treatments of her PPG and several surgeries.<\/jats:p>\n <\/jats:sec>\n \n CASE:<\/jats:title>\n Ms T. was a 39-year-old woman with Crohn's disease who underwent several ileostomies, developed PPG, and failed treatment with adalimumab. Her PPG was successfully treated topically with crushed prednisone tablets.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n We found that crushed corticosteroid tablets were an effective treatment of PPG, due to the ability to reduce pain and allow adhesion of the ostomy appliance.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/won.0000000000000798","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T15:38:05Z","timestamp":1631115485000},"page":"460-462","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Crushed Corticosteroid Tablets in Peristomal Pyoderma Gangrenosum"],"prefix":"10.1097","volume":"48","author":[{"given":"Martina","family":"Burlando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Paravisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Bodini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Cozzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Parodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"3","key":"R1-20250806","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s40257-017-0251-7","article-title":"Pyoderma gangrenosum: an update on pathophysiology, diagnosis and treatment","volume":"18","author":"Alavi","year":"2017","journal-title":"Am J Clin Dermatol"},{"issue":"5","key":"R2-20250806","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/iwj.13164","article-title":"A novel topical therapy for resistant and early peristomal pyoderma gangrenosum","volume":"16","author":"Pearson","year":"2019","journal-title":"Int Wound J"},{"issue":"3","key":"R3-20250806","doi-asserted-by":"crossref","first-page":"224","DOI":"10.7861\/clinmedicine.19-3-224","article-title":"Pyoderma gangrenosum\u2014a guide to diagnosis and management","volume":"19","author":"George","year":"2019","journal-title":"Clin Med (Lond)"},{"issue":"6","key":"R4-20250806","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.jaad.2017.12.049","article-title":"Diagnosis and management of peristomal pyoderma gangrenosum: a systematic review","volume":"78","author":"Afifi","year":"2018","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"R5-20250806","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/WON.0000000000000657","article-title":"Peristomal pyoderma gangrenosum in a rectal cancer patient with an ileostomy: a case study","volume":"47","author":"Santacruz Cerd\u00e1n","year":"2020","journal-title":"J Wound Ostomy Continence Nurs"},{"issue":"2","key":"R6-20250806","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/WON.0000000000000745","article-title":"Italian guidelines for the nursing management of enteral and urinary stomas in adults: an executive summary","volume":"48","author":"Roveron","year":"2021","journal-title":"J Wound Ostomy Continence Nurs"},{"issue":"2","key":"R7-20250806","doi-asserted-by":"crossref","first-page":"e14736","DOI":"10.1111\/dth.14736","article-title":"Treatment of pyoderma gangrenosum: a multicenter survey-based study assessing satisfaction and quality of life","volume":"34","author":"Hobbs","year":"2021","journal-title":"Dermatol Ther"},{"key":"R8-20250806","doi-asserted-by":"crossref","first-page":"F1000 Faculty Rev-2092","DOI":"10.12688\/f1000research.19909.1","article-title":"Recent advances in managing and understanding pyoderma gangrenosum","volume":"8","author":"Fletcher","year":"2019","journal-title":"F1000Res"},{"issue":"6","key":"R9-20250806","first-page":"50","article-title":"Treating peristomal pyoderma gangrenosum with topical crushed prednisone: a report of three cases","volume":"60","author":"Demartyn","year":"2014","journal-title":"Ostomy Wound Manag"}],"container-title":["Journal of Wound, Ostomy & Continence Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/WON.0000000000000798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T15:02:37Z","timestamp":1754492557000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/WON.0000000000000798"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1097\/won.0000000000000798","relation":{},"ISSN":["1071-5754"],"issn-type":[{"value":"1071-5754","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}