{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:41:41Z","timestamp":1792291301102,"version":"4.4.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE:<\/jats:title>\n            <jats:p>The purpose of this study was to analyze the influence of a diabetic foot ulcer on all-cause and cardiovascular disease (CVD) mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>DESIGN:<\/jats:title>\n            <jats:p>Retrospective case-control study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SUBJECTS AND SETTING OUTPATIENTS:<\/jats:title>\n            <jats:p>Eighty-eight patients with new-onset diabetic foot ulceration (DFU) were paired with 176 patients without DFU (controls). The study setting was the Department of Endocrinology, Sun Yat-sen Memorial Hospital, located in Guangzhou, China.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Cause-specific mortality was recorded during a median follow-up duration of 6.20 years up to 1 March 2016. Records review dates were from January 1, 2004, to December 31, 2010.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>The all-cause mortality rate for the DFU group and the control group was 48.9% and 22.7%, respectively. The risk of all-cause death in the DFU group was 3.126 times higher than that in the control group (risk ratio [RR]= 3.126; 95% CI, 1.998-4.891; <jats:italic toggle=\"yes\">P<\/jats:italic> = .000). The CVD mortality rate of the DFU group and the control group was 12.5% and 6.8%, respectively. The risk of CVD death in the DFU group was 3.277 times higher than that in the control group (RR = 3.277; 95% CI, 1.392-7.715; <jats:italic toggle=\"yes\">P<\/jats:italic> = .007).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Development of a diabetic foot ulcer was associated with a significantly higher all-cause and CVD-related death risk than that in a control group of persons with diabetes mellitus without DFU.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/won.0000000000000856","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T15:05:11Z","timestamp":1646665511000},"page":"175-179","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["Influence of Foot Ulceration on All-Cause and Cardiovascular Mortality in Diabetic Patients"],"prefix":"10.1097","volume":"49","author":[{"given":"Liangzhi","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"9","key":"R2-20250806","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.2337\/dc12-1272","article-title":"Sex differences in all-cause and cardiovascular mortality, hospitalization for individuals with and without diabetes, and patients with diabetes diagnosed early and late","volume":"36","author":"Roche","year":"2013","journal-title":"Diabetes Care"},{"issue":"3","key":"R3-20250806","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/0218492312451983","article-title":"Diabetic control and coronary artery bypass: effect on short-term outcomes","volume":"21","author":"Strahan","year":"2013","journal-title":"Asian Cardiovasc Thorac Ann"},{"issue":"5","key":"R4-20250806","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/dmrr.657","article-title":"Vibration perception threshold\u2014a valuable assessment of neural dysfunction in people with diabetes","volume":"22","author":"Garrow","year":"2006","journal-title":"Diabetes Metab Res Rev"},{"issue":"2","key":"R6-20250806","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/107110078100200202","article-title":"The dysvascular foot: a system for diagnosis and treatment","volume":"2","author":"Wagner","year":"1981","journal-title":"Foot Ankle"},{"issue":"4","key":"R7-20250806","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1742-481X.2007.00392.x","article-title":"Guest Editorial: are diabetes-related wounds and amputations worse than cancer","volume":"4","author":"Armstrong","year":"2007","journal-title":"Int Wound J"},{"issue":"5","key":"R8-20250806","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/iwj.12404","article-title":"The impact of foot ulceration and amputation on mortality in diabetic patients. I: from ulceration to death, a systematic review","volume":"13","author":"Jupiter","year":"2016","journal-title":"Int Wound J"},{"issue":"5","key":"R9-20250806","doi-asserted-by":"crossref","first-page":"816","DOI":"10.2337\/dc08-1695","article-title":"Mortality risk of Charcot arthropathy compared with that of diabetic foot ulcer and diabetes alone","volume":"32","author":"Sohn","year":"2008","journal-title":"Diabetes Care"},{"issue":"5","key":"R10-20250806","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.metabol.2008.01.004","article-title":"Cardiovascular risk profile and morbidity in subjects affected by type 2 diabetes mellitus with and without diabetic foot","volume":"57","author":"Pinto","year":"2008","journal-title":"Metabolism"},{"issue":"3","key":"R11-20250806","first-page":"201","article-title":"The outcomes of toe amputations in diabetic patients: a 5-year follow-up study","volume":"28","author":"Haojie","year":"2012","journal-title":"Chin J Diabetes Mellit"},{"issue":"2","key":"R12-20250806","first-page":"128","article-title":"Relationship between long-term mortality and diabetic complications in 139 patients with diabetic foot ulcer","volume":"27","author":"Xiang","year":"2011","journal-title":"Chin J Diabetes Mellit"},{"issue":"5","key":"R13-20250806","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/j.1464-5491.2011.03262.x","article-title":"History of foot ulcers increases mortality among patients with diabetes in Northern Thailand","volume":"28","author":"Junrungsee","year":"2011","journal-title":"Diabetic Med"},{"issue":"11","key":"R14-20250806","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1007\/s00125-012-2673-3","article-title":"The association of ulceration of the foot with cardiovascular and all-cause mortality in patients with diabetes: a meta-analysis","volume":"55","author":"Brownrigg","year":"2012","journal-title":"Diabetologia"},{"issue":"12","key":"R15-20250806","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.2337\/dc09-0651","article-title":"History of foot ulcer increases mortality among individuals with diabetes","volume":"32","author":"Iversen","year":"2009","journal-title":"Diabetes Care"},{"issue":"9","key":"R16-20250806","first-page":"88","article-title":"The association of ulceration of the foot with cardiovascular and all-cause mortality in patients with diabetes: a meta-analysis","author":"Yang","year":"2014","journal-title":"J Nurs Sci"},{"issue":"12","key":"R18-20250806","first-page":"1177","article-title":"Chinese expert consensus on multiple cardiovascular risk factors in diabetic patients","author":"Dayi","year":"2010","journal-title":"Chin J Hypertens"},{"issue":"1","key":"R19-20250806","first-page":"6","article-title":"Causes of death in inpatients with diabetes in 15 provinces from 1991 to 2005","author":"Huabing","year":"2009","journal-title":"Chin J Diabetes Mellit"},{"issue":"5","key":"R21-20250806","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1055\/s-0029-1241215","article-title":"In-hospital mortality in a tertiary referral hospital: causes of death and comparison between patients with and without diabetes","volume":"118","author":"Papazafiropoulou","year":"2010","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"2","key":"R22-20250806","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2337\/diacare.27.2.407","article-title":"Health-related quality of life and health adjusted life expectancy of people with diabetes in Ontario, Canada, 1996-1997","volume":"27","author":"Manuel","year":"2004","journal-title":"Diabetes Care"},{"issue":"suppl 2","key":"R23-20250806","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1007\/PL00002934","article-title":"Mortality and causes of death in the WHO multinational study of vascular disease in diabetes","volume":"44","author":"Morrish","year":"2001","journal-title":"Diabetologia"},{"issue":"7","key":"R24-20250806","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.2337\/dc14-2498","article-title":"Cardiovascular and all-cause mortality over a 23-year period among Chinese with newly diagnosed diabetes in the Da Qing IGT and Diabetes Study","volume":"38","author":"An","year":"2015","journal-title":"Diabetes Care"},{"issue":"3","key":"R25-20250806","doi-asserted-by":"crossref","first-page":"122","DOI":"10.7326\/0003-4819-147-3-200708070-00167","article-title":"Mortality trends in men and women with diabetes, 1971 to 2000","volume":"147","author":"Gregg","year":"2007","journal-title":"Ann Intern Med"},{"issue":"14","key":"R26-20250806","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1001\/jama.281.14.1291","article-title":"Diabetes and decline in heart disease mortality in US adults","volume":"281","author":"Gu","year":"1999","journal-title":"JAMA"},{"issue":"20","key":"R27-20250806","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1001\/jama.292.20.2495","article-title":"Trends in cardiovascular complications of diabetes","volume":"292","author":"Fox","year":"2004","journal-title":"JAMA"},{"issue":"13","key":"R28-20250806","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1161\/CIRCULATIONAHA.108.829176","article-title":"Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005","volume":"119","author":"Preis","year":"2009","journal-title":"Circulation"},{"issue":"5","key":"R29-20250806","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1001\/archinternmed.2011.2","article-title":"Impact of diabetes on cardiovascular disease risk and all-cause mortality in older men: influence of age at onset, diabetes duration, and established and novel risk factors","volume":"171","author":"Wannamethee","year":"2011","journal-title":"Arch Intern Med"},{"issue":"7","key":"R30-20250806","first-page":"397","article-title":"Status of blood glucose control and treatment of type 2 diabetes in China","volume":"4","author":"Linong","year":"2012","journal-title":"Chin J Diabetes Mellit"},{"issue":"6","key":"R31-20250806","first-page":"710","article-title":"Control of cardiovascular risk factors in patients with type 2 diabetes and coronary heart disease","author":"Jie","year":"2012","journal-title":"J Cardiopulm Rehabil Pulm Dis"},{"issue":"4","key":"R32-20250806","first-page":"302","article-title":"The status of the controlling of cardiovascular risk factors in diabetic patients with overweight or obesity in Guangdong Province","author":"Rongping","year":"2014","journal-title":"Chin J Diabetes Mellit"},{"issue":"11","key":"R33-20250806","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.2337\/dc08-1242","article-title":"Improved survival of diabetic foot ulcer patients 1995-2008: possible impact of aggressive cardiovascular risk management","volume":"31","author":"Young","year":"2008","journal-title":"Diabetes Care"}],"container-title":["Journal of Wound, Ostomy &amp; Continence Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/WON.0000000000000856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T15:03:33Z","timestamp":1754492613000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/WON.0000000000000856"}},"subtitle":["A Case-Control Study"],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1097\/won.0000000000000856","relation":{},"ISSN":["1071-5754"],"issn-type":[{"value":"1071-5754","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}