{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:24:46Z","timestamp":1793420686440,"version":"4.5.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>We aim to evaluate recurrence rates of gallstone pancreatitis in children undergoing early vs interval cholecystectomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>STUDY DESIGN<\/jats:title>\n            <jats:p>A multicenter, retrospective review of pediatric patients admitted with gallstone pancreatitis from 2010 through 2017 was performed. Children were evaluated based on timing of cholecystectomy. Early cholecystectomy was defined as surgery during the index admission, whereas the delayed group was defined as no surgery or surgery after discharge. Outcomes, recurrence rates, and complications were evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>Of 246 patients from 6 centers with gallstone pancreatitis, 178 (72%) were female, with mean age 13.5 \u00b1 3.2 years and a mean body mass index of 28.9 \u00b1 15.2. Most (90%) patients were admitted with mild pancreatitis (Atlanta Classification). Early cholecystectomy was performed in 167 (68%) patients with no difference in early cholecystectomy rates across institutions. Delayed group patients weighed less (61\u2009kg vs. 72\u2009kg, p = 0.003) and were younger (12 vs. 14 years, p = 0.001) than those who underwent early cholecystectomy. However, there were no differences in clinical, radiological, or laboratory characteristics between groups. There were 4 (2%) episodes of postoperative recurrent pancreatitis in the early group compared with 22% in the delayed group. More importantly, when cholecystectomy was delayed more than 6 weeks from index discharge, recurrence approached 60%. There were no biliary complications in any group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS<\/jats:title>\n            <jats:p>Cholecystectomy during the index admission for children with gallstone pancreatitis reduces recurrent pancreatitis. Recurrence proportionally increases with time when patients are treated with a delayed approach.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/xcs.0000000000000062","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T01:00:38Z","timestamp":1649120438000},"page":"352-358","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Index Admission Cholecystectomy and Recurrence of Pediatric Gallstone Pancreatitis: Multicenter Cohort Analysis"],"prefix":"10.1097","volume":"234","author":[{"given":"Armando S","family":"Mu\u00f1oz Abraham","sequence":"first","affiliation":[{"name":"From the Section of Pediatric Surgery, Cardinal Glennon Children\u2019s Medical Center, Saint Louis University School of Medicine, St. Louis, MO (Mu\u00f1oz Abraham, Osei, Greenspon, Willalona)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Osei","sequence":"additional","affiliation":[{"name":"From the Section of Pediatric Surgery, Cardinal Glennon Children\u2019s Medical Center, Saint Louis University School of Medicine, St. Louis, MO (Mu\u00f1oz Abraham, Osei, Greenspon, Willalona)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Bajinting","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saint Louis Children\u2019s Hospital, Washington University School of Medicine, St. Louis, MO (Bajinting, Keller)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Cowles","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery and Department of Surgery, Yale University School of Medicine, New Haven, CT (Cowles, Shaughnessy)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Greenspon","sequence":"additional","affiliation":[{"name":"From the Section of Pediatric Surgery, Cardinal Glennon Children\u2019s Medical Center, Saint Louis University School of Medicine, St. Louis, MO (Mu\u00f1oz Abraham, Osei, Greenspon, Willalona)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brain D","family":"Hosfield","sequence":"additional","affiliation":[{"name":"Department of Surgery, Riley Hospital for Children at IU Health, Indiana University School of Medicine, Indianapolis, IN (Hosfield, Landman)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saint Louis Children\u2019s Hospital, Washington University School of Medicine, St. Louis, MO (Bajinting, Keller)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P","family":"Landman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Riley Hospital for Children at IU Health, Indiana University School of Medicine, Indianapolis, IN (Hosfield, Landman)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hawkins","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Surgery, Texas Children\u2019s Hospital and Baylor College of Medicine, Houston, TX (Owens, Vogel)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P","family":"Shaughnessy","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery and Department of Surgery, Yale University School of Medicine, New Haven, CT (Cowles, Shaughnessy)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn D","family":"St. Peter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Mercy Hospital, Kansas City MO (St. Peter, Sujka)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Sujka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Mercy Hospital, Kansas City MO (St. Peter, Sujka)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Texas Children\u2019s Hospital and Baylor College of Medicine, Houston, TX (Owens, Vogel)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A","family":"Villalona","sequence":"additional","affiliation":[{"name":"From the Section of Pediatric Surgery, Cardinal Glennon Children\u2019s Medical Center, Saint Louis University School of Medicine, St. Louis, MO (Mu\u00f1oz Abraham, Osei, Greenspon, Willalona)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"R1-20250821","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.suc.2014.01.006","article-title":"Gallstone pancreatitis.","volume":"94","author":"Cucher","year":"2014","journal-title":"Surg Clin North Am"},{"key":"R2-20250821","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/MPA.0b013e3181baac47","article-title":"Increasing incidence of acute pancreatitis at an American pediatric tertiary care center: Is greater awareness among physicians responsible?","volume":"39","author":"Morinville","year":"2010","journal-title":"Pancreas"},{"key":"R3-20250821","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/j.1440-1746.2007.04936.x","article-title":"Changing incidence of acute pancreatitis: 10-year experience at the Royal Children\u2019s Hospital, 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