{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:50:35Z","timestamp":1787835035332,"version":"build-2784847793"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1097\/yco.0000000000000046","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T08:43:22Z","timestamp":1389948202000},"page":"138-142","source":"Crossref","is-referenced-by-count":25,"title":["Lifetime requirement of the methionine cycle for neuronal development and maintenance"],"prefix":"10.1097","volume":"27","author":[{"given":"Thomas B.","family":"Shea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-9-20210206","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0166-2236(03)00032-8","article-title":"Folate and homocysteine in neural plasticity and neurodegenerative disorders.","volume":"26","author":"Mattson","year":"2003","journal-title":"Trends Neurosci"},{"key":"R3-9-20210206","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1093\/ilar.53.3-4.322","article-title":"Gene-environment interactions and epigenetic pathways in autism: the importance of one-carbon metabolism.","volume":"53","author":"Schaevitz","year":"2012","journal-title":"ILAR J"},{"key":"R4-9-20210206","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/jnr.10416","article-title":"Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage.","volume":"70","author":"Ho","year":"2002","journal-title":"J Neurosci Res"},{"key":"R5-9-20210206","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.gene.2013.09.063","article-title":"Folate: metabolism, genes, polymorphisms and the associated diseases.","volume":"533","author":"Nazki","year":"2014","journal-title":"Gene"},{"key":"R6-9-20210206","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.biochi.2012.11.017","article-title":"Vitamin B12 in neurology and ageing; clinical and genetic aspects.","volume":"95","author":"McCaddon","year":"2013","journal-title":"Biochimie"},{"key":"R7-9-20210206","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.mehy.2008.04.013","article-title":"Has enhanced folate status during pregnancy altered natural selection and possibly autism prevalence A closer look at a possible link.","volume":"7","author":"Rogers","year":"2008","journal-title":"Med Hypotheses"},{"key":"R8-9-20210206","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.gene.2013.09.098","article-title":"Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level.","volume":"533","author":"Weiner","year":"2014","journal-title":"Gene"},{"key":"R9-9-20210206","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1515\/revneuro-2013-0008","article-title":"Histone lysine methylation: critical regulator of memory and behavior.","volume":"24","author":"Jarome","year":"2013","journal-title":"Rev Neurosci"},{"key":"R10-9-20210206","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1534\/genetics.113.153981","article-title":"Nutritional control of epigenetic processes in yeast and human cells.","volume":"195","author":"Sadhu","year":"2013","journal-title":"Genetics"},{"key":"R11-9-20210206","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1101\/lm.029363.112","article-title":"Histone H3 lysine methylation in cognition and intellectual disability disorders.","volume":"20","author":"Parkel","year":"2013","journal-title":"Learn Mem"},{"key":"R12-9-20210206","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2174\/138920210791233090","article-title":"One-carbon metabolism and Alzheimers disease: focus on epigenetics.","volume":"11","author":"Coppede","year":"2010","journal-title":"Curr Genomics"},{"key":"R13-9-20210206","first-page":"1192","article-title":"One-carbon metabolism and Alzheimers disease: is it all a methylation matter Neurobiol","volume":"32","author":"Fuso","year":"2011","journal-title":"Aging"},{"key":"R14-9-20210206","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00702-012-0849-0","article-title":"Positive argument for debate in J Neural Transmission: Alzheimers disease - are we intervening too late Yes, by decades.","volume":"119","author":"Shea","year":"2012","journal-title":"J Neural Trans"},{"key":"R15-9-20210206","first-page":"67","article-title":"S-adenosyl methionine: a natural therapeutic agent effective against multiple hallmarks and risk factors associated with Alzheimers disease.","volume":"1","author":"Shea","year":"2008","journal-title":"J Alz Dis"},{"key":"R16-9-20210206","first-page":"423","article-title":"Dietary supplementation with S-adenosyl methionine delayed Abeta and tau pathology in 3xTg-AD mice.","volume":"28","author":"Lee","year":"2011","journal-title":"J Alz Dis"},{"key":"R17-9-20210206","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00702-003-0096-5","article-title":"Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive function.","volume":"111","author":"Kennedy","year":"2004","journal-title":"J Neur Trans"},{"key":"R18-9-20210206","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1136\/jnnp.53.12.1096","article-title":"Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.","volume":"53","author":"Bottiglieri","year":"1990","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R19-9-20210206","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.neurobiolaging.2012.10.013","article-title":"Oxidative stress induces DNA demethylation and histone acetylation in SH-SY5Y cells: potential epigenetic mechanisms in gene transcription in A production.","volume":"34","author":"Gu","year":"2013","journal-title":"Neurobiol Aging"},{"key":"R20-9-20210206","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.bbamem.2009.01.012","article-title":"The interaction of beta-amyloid protein with cellular membranes stimulates its own production.","volume":"1788","author":"Peters","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"R21-9-20210206","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1471-4159.2007.05072.x","article-title":"Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein.","volume":"104","author":"Tamagno","year":"2008","journal-title":"J Neurochem"},{"key":"R23-9-20210206","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3945\/jn.112.161828","article-title":"Status of vitamins B-12 and B-6 but not of folate, homocysteine, and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults.","volume":"142","author":"Moorthy","year":"2012","journal-title":"J Nutr"},{"key":"R24-9-20210206","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1517\/13543784.2011.601740","article-title":"Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before.","volume":"20","author":"Mancuso","year":"2011","journal-title":"Expert Opin Investig Drugs"},{"key":"R25-9-20210206","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.jada.2007.09.008","article-title":"Poor nutrient intakes during 1-year follow-up with community-dwelling older adults with early-stage Alzheimer dementia compared to cognitively intact matched controls.","volume":"107","author":"Shatenstein","year":"2007","journal-title":"J Am Diet Assoc"},{"key":"R26-9-20210206","first-page":"75","article-title":"REAL. FR GroupImpact of nutritional status on the evolution of Alzheimers disease and on response to acetylcholinesterase inhibitor treatment.","volume":"9","author":"Vellas","year":"2005","journal-title":"J Nutr Health Aging"},{"key":"R27-9-20210206","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/ars.2011.4368","article-title":"Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimers disease patients and healthy controls.","volume":"17","author":"Coppede","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"R28-9-20210206","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1155\/2013\/524106","article-title":"The MTHFR 677T allele may influence the severity and biochemical risk factors of Alzheimers disease in an Egyptian population.","volume":"35","author":"Elhawary","year":"2013","journal-title":"Dis Markers"},{"key":"R29-9-20210206","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF02982630","article-title":"Dietary and genetic compromise in folate availability reduces acetylcholine and cognitive performance: critical role of S-adenosylmethionine.","volume":"12","author":"Chan","year":"2008","journal-title":"J Health Nutr Aging"},{"key":"R30-9-20210206","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1177\/1533317508325093","article-title":"Efficacy of a vitaminnutriceutical formulation for early-stage Alzheimers disease: a one-year open-label pilot study with a 16-month extension.","volume":"23","author":"Chan","year":"2008","journal-title":"Am J Alz Dis Other Dementias"},{"key":"R31-9-20210206","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s12603-010-0054-5","article-title":"Efficacy of a vitaminnutriceutical formulation on cognitive speed and recall in adults with no known or suspected dementia.","volume":"14","author":"Chan","year":"2010","journal-title":"J Nutr Health Aging"},{"key":"R32-9-20210206","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/1533317508325094","article-title":"Efficacy of a vitaminnutriceutical formulation for moderate to late-stage Alzheimers disease: A placebo-controlled pilot study.","volume":"24","author":"Remington","year":"2009","journal-title":"Am J Alz Dis Other Dementias"}],"container-title":["Current Opinion in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/YCO.0000000000000046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T08:29:00Z","timestamp":1716452940000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00001504-201403000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1097\/yco.0000000000000046","relation":{},"ISSN":["0951-7367"],"issn-type":[{"value":"0951-7367","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}