{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:26:25Z","timestamp":1791271585740,"version":"4.1.0"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1097\/yco.0b013e3282fad375","type":"journal-article","created":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T07:01:54Z","timestamp":1207033314000},"page":"290-295","source":"Crossref","is-referenced-by-count":186,"title":["The contribution of failing adult hippocampal neurogenesis to psychiatric disorders"],"prefix":"10.1097","volume":"21","author":[{"given":"Gerd","family":"Kempermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Fabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20210206","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ana.10262","article-title":"Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment","volume":"52","author":"Kempermann","year":"2002","journal-title":"Ann Neurol"},{"key":"R2-13-20210206","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/cne.901240303","article-title":"Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats","volume":"124","author":"Altman","year":"1965","journal-title":"J Comp Neurol"},{"key":"R5-13-20210206","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nn1969","article-title":"Adult hippocampal neurogenesis in depression","volume":"10","author":"Sahay","year":"2007","journal-title":"Nat Neurosci"},{"key":"R6-13-20210206","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/hipo.20167","article-title":"A functional hypothesis for adult hippocampal neurogenesis: avoidance of catastrophic interference in the dentate gyrus","volume":"16","author":"Wiskott","year":"2006","journal-title":"Hippocampus"},{"key":"R7-13-20210206","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nn1707","article-title":"Potential role for adult neurogenesis in the encoding of time in new memories","volume":"9","author":"Aimone","year":"2006","journal-title":"Nat Neurosci"},{"key":"R8-13-20210206","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tics.2006.10.013","article-title":"A model of hippocampal neurogenesis in memory and mood disorders","volume":"11","author":"Becker","year":"2007","journal-title":"Trends Cogn Sci"},{"key":"R9-13-20210206","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.expneurol.2007.03.006","article-title":"Amyloid, memory and neurogenesis","volume":"205","author":"Morgan","year":"2007","journal-title":"Exp Neurol"},{"key":"R10-13-20210206","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1073\/pnas.2634794100","article-title":"Increased hippocampal neurogenesis in Alzheimer's disease","volume":"101","author":"Jin","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R11-13-20210206","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2217\/17460751.1.1.15","article-title":"Adult neurogenesis and neurodegenerative disorders","volume":"1","author":"Steiner","year":"2006","journal-title":"Regen Med"},{"key":"R12-13-20210206","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1471-4159.2006.04241.x","article-title":"Dopamine and adult neurogenesis","volume":"100","author":"Borta","year":"2007","journal-title":"J Neurochem"},{"key":"R14-13-20210206","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00406-007-0731-5","article-title":"Adult hippocampal neurogenesis and aging","volume":"257","author":"Klempin","year":"2007","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"R15-13-20210206","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00406-007-0732-4","article-title":"Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant?","volume":"257","author":"Kuhn","year":"2007","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"R16-13-20210206","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1586\/14737175.7.7.853","article-title":"Regulation of adult hippocampal neurogenesis: relevance to depression","volume":"7","author":"Vaidya","year":"2007","journal-title":"Expert Rev Neurother"},{"key":"R17-13-20210206","doi-asserted-by":"crossref","first-page":"73754","DOI":"10.1155\/2007\/73754","article-title":"Hippocampal neurogenesis, depressive disorders, and antidepressant therapy","volume":"2007","author":"Paizanis","year":"2007","journal-title":"Neural Plast"},{"key":"R18-13-20210206","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2174\/187152707783220929","article-title":"Regulation of neurogenesis and gliogenesis by stress and antidepressant treatment","volume":"6","author":"Banasr","year":"2007","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"R19-13-20210206","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.npp.1301574","article-title":"Stress, depression, and neuroplasticity: a convergence of mechanisms","volume":"33","author":"Pittenger","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"R20-13-20210206","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00406-007-0728-0","article-title":"What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?","volume":"257","author":"Czeh","year":"2007","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"R21-13-20210206","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jpsychires.2006.06.007","article-title":"Causality of stem cell based neurogenesis and depression: to be or not to be, is that the question?","volume":"41","author":"Feldmann","year":"2007","journal-title":"J Psychiatr Res"},{"key":"R23-13-20210206","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/nature04108","article-title":"Wnt signalling regulates adult hippocampal neurogenesis","volume":"437","author":"Lie","year":"2005","journal-title":"Nature"},{"key":"R24-13-20210206","doi-asserted-by":"crossref","first-page":"12156","DOI":"10.1523\/JNEUROSCI.1898-07.2007","article-title":"The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus","volume":"27","author":"Thakker-Varia","year":"2007","journal-title":"J Neurosci"},{"key":"R26-13-20210206","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1523\/JNEUROSCI.0237-07.2007","article-title":"Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates","volume":"27","author":"Perera","year":"2007","journal-title":"J Neurosci"},{"key":"R27-13-20210206","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/sj.mp.4001791","article-title":"Neural stem cell proliferation is decreased in schizophrenia, but not in depression","volume":"11","author":"Reif","year":"2006","journal-title":"Mol Psychiatry"},{"key":"R28-13-20210206","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"R29-13-20210206","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/sj.npp.1301399","article-title":"Behavioral effects of chronic fluoxetine in BALB\/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor","volume":"33","author":"Holick","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"R30-13-20210206","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1073\/pnas.0510291103","article-title":"Natural variation and genetic covariance in adult hippocampal neurogenesis","volume":"103","author":"Kempermann","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R31-13-20210206","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00406-007-0733-3","article-title":"Neurogenesis and schizophrenia: dividing neurons in a divided mind?","volume":"257","author":"Reif","year":"2007","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"R32-13-20210206","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.schres.2006.09.030","article-title":"Adult neurogenesis and schizophrenia: a window on abnormal early brain development?","volume":"90","author":"Toro","year":"2007","journal-title":"Schizophr Res"},{"key":"R33-13-20210206","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1176\/appi.ajp.161.11.1957","article-title":"Hippocampal volume and depression: a meta-analysis of MRI studies","volume":"161","author":"Videbech","year":"2004","journal-title":"Am J Psychiatry"},{"key":"R34-13-20210206","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1192\/bjp.188.6.510","article-title":"Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies","volume":"188","author":"Steen","year":"2006","journal-title":"Br J Psychiatry"},{"key":"R35-13-20210206","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainresrev.2006.12.008","article-title":"Hippocampal abnormalities and memory deficits: new evidence of a strong pathophysiological link in schizophrenia","volume":"54","author":"Boyer","year":"2007","journal-title":"Brain Res Rev"},{"key":"R36-13-20210206","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1523\/JNEUROSCI.1120-05.2005","article-title":"Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs","volume":"25","author":"Kippin","year":"2005","journal-title":"J Neurosci"},{"key":"R37-13-20210206","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s007020050061","article-title":"Adult treatment with haloperidol increases dentate granule cell proliferation in the gerbil hippocampus","volume":"105","author":"Dawirs","year":"1998","journal-title":"J Neural Transm"},{"key":"R38-13-20210206","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00702-003-0070-2","article-title":"Hippocampal volume and cell proliferation after acute and chronic clozapine or haloperidol treatment","volume":"111","author":"Schmitt","year":"2004","journal-title":"J Neural Transm"},{"key":"R39-13-20210206","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/syn.20275","article-title":"Effects of repeated phencyclidine administration on adult hippocampal neurogenesis in the rat","volume":"60","author":"Liu","year":"2006","journal-title":"Synapse"},{"key":"R40-13-20210206","doi-asserted-by":"crossref","first-page":"13178","DOI":"10.1073\/pnas.202035899","article-title":"Reelin, disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus","volume":"99","author":"Forster","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R41-13-20210206","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1523\/JNEUROSCI.5516-05.2006","article-title":"Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus","volume":"26","author":"Heinrich","year":"2006","journal-title":"J Neurosci"},{"key":"R42-13-20210206","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000096213","article-title":"Balance between neurogenesis and gliogenesis in the adult hippocampus: role for reelin","volume":"29","author":"Zhao","year":"2007","journal-title":"Dev Neurosci"},{"key":"R43-13-20210206","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.expneurol.2005.12.008","article-title":"Reelin-deficient mice show impaired neurogenesis and increased stroke size","volume":"198","author":"Won","year":"2006","journal-title":"Exp Neurol"},{"key":"R44-13-20210206","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/schbul\/sbj079","article-title":"Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness","volume":"32","author":"Hennah","year":"2006","journal-title":"Schizophr Bull"},{"key":"R45-13-20210206","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.molmed.2006.04.009","article-title":"Disrupted in schizophrenia 1: building brains and memories","volume":"12","author":"Porteous","year":"2006","journal-title":"Trends Mol Med"},{"key":"R46-13-20210206","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuron.2006.09.015","article-title":"Neurobiology of schizophrenia","volume":"52","author":"Ross","year":"2006","journal-title":"Neuron"},{"key":"R47-13-20210206","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1073\/pnas.0511189103","article-title":"Disc1 is mutated in the 129S6\/SvEv strain and modulates working memory in mice","volume":"103","author":"Koike","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R48-13-20210206","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2007.07.010","article-title":"Disrupted-in-schizophrenia 1 regulates integration of newly generated neurons in the adult brain","volume":"130","author":"Duan","year":"2007","journal-title":"Cell"},{"key":"R49-13-20210206","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cell.2007.09.004","article-title":"DISC1 puts the brakes on neurogenesis","volume":"130","author":"Dranovsky","year":"2007","journal-title":"Cell"},{"key":"R50-13-20210206","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1136\/jmg.40.5.325","article-title":"Disruption of the neuronal PAS3 gene in a family affected with schizophrenia","volume":"40","author":"Kamnasaran","year":"2003","journal-title":"J Med Genet"},{"key":"R51-13-20210206","doi-asserted-by":"crossref","first-page":"13648","DOI":"10.1073\/pnas.0405310101","article-title":"Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors","volume":"101","author":"Erbel-Sieler","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R52-13-20210206","doi-asserted-by":"crossref","first-page":"14052","DOI":"10.1073\/pnas.0506713102","article-title":"The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice","volume":"102","author":"Pieper","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R53-13-20210206","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.biopsych.2005.11.002","article-title":"Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology","volume":"60","author":"Harrison","year":"2006","journal-title":"Biol Psychiatry"},{"key":"R54-13-20210206","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1073\/pnas.0510410103","article-title":"The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone","volume":"103","author":"Ghashghaei","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R55-13-20210206","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1586\/14737175.7.1.29","article-title":"Schizophrenia: more evidence for less glutamate","volume":"7","author":"Morrison","year":"2007","journal-title":"Expert Rev Neurother"},{"key":"R56-13-20210206","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10571-006-9062-8","article-title":"Glutamate and schizophrenia: beyond the dopamine hypothesis","volume":"26","author":"Coyle","year":"2006","journal-title":"Cell Mol Neurobiol"},{"key":"R57-13-20210206","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/hipo.20160","article-title":"The role of N-methyl-D-asparate receptors in neurogenesis","volume":"16","author":"Nacher","year":"2006","journal-title":"Hippocampus"},{"key":"R58-13-20210206","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00406-007-0730-6","article-title":"Adult neurogenesis and the memories of drug addiction","volume":"257","author":"Canales","year":"2007","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"R59-13-20210206","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/hipo.20162","article-title":"Alcohol and adult neurogenesis: roles in neurodegeneration and recovery in chronic alcoholism","volume":"16","author":"Nixon","year":"2006","journal-title":"Hippocampus"},{"key":"R60-13-20210206","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1017\/S1461145705005286","article-title":"Moderate ethanol consumption increases hippocampal cell proliferation and neurogenesis in the adult mouse","volume":"8","author":"Aberg","year":"2005","journal-title":"Int J Neuropsychopharmacol"},{"key":"R61-13-20210206","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1111\/j.1530-0277.2006.00239.x","article-title":"BHT blocks NF-kappaB activation and ethanol-induced brain damage","volume":"30","author":"Crews","year":"2006","journal-title":"Alcohol Clin Exp Res"},{"key":"R62-13-20210206","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.nbd.2007.02.011","article-title":"Single alcohol exposure in early life damages hippocampal stem\/progenitor cells and reduces adult neurogenesis","volume":"26","author":"Ieraci","year":"2007","journal-title":"Neurobiol Dis"},{"key":"R63-13-20210206","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1111\/j.1530-0277.2007.00528.x","article-title":"Persistent impairment of hippocampal neurogenesis in young adult rats following early postnatal alcohol exposure","volume":"31","author":"Klintsova","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"R64-13-20210206","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/hipo.20164","article-title":"Hippocampal cell proliferation is reduced following prenatal ethanol exposure but can be rescued with voluntary exercise","volume":"16","author":"Redila","year":"2006","journal-title":"Hippocampus"},{"key":"R65-13-20210206","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/hipo.20161","article-title":"Opiates, psychostimulants, and adult hippocampal neurogenesis: insights for addiction and stem cell biology","volume":"16","author":"Eisch","year":"2006","journal-title":"Hippocampus"},{"key":"R66-13-20210206","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1007\/s00018-007-7063-5","article-title":"Adult hippocampal neurogenesis: regulation by HIV and drugs of abuse","volume":"64","author":"Venkatesan","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"R67-13-20210206","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1460-9568.2006.04924.x","article-title":"Chronic cocaine exposure impairs progenitor proliferation but spares survival and maturation of neural precursors in adult rat dentate gyrus","volume":"24","author":"Dominguez-Escriba","year":"2006","journal-title":"Eur J Neurosci"},{"key":"R68-13-20210206","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.neuropharm.2006.06.019","article-title":"Binge administration of 3,4-methylenedioxymethamphetamine (\u2018ecstasy\u2019) impairs the survival of neural precursors in adult rat dentate gyrus","volume":"51","author":"Hernandez-Rabaza","year":"2006","journal-title":"Neuropharmacology"}],"container-title":["Current Opinion in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/YCO.0b013e3282fad375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T07:42:58Z","timestamp":1620978178000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00001504-200805000-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/yco.0b013e3282fad375","relation":{},"ISSN":["0951-7367"],"issn-type":[{"value":"0951-7367","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}