{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:28:01Z","timestamp":1771331281683,"version":"3.50.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1097\/ypg.0000000000000082","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T21:48:05Z","timestamp":1424900885000},"page":"106-111","source":"Crossref","is-referenced-by-count":25,"title":["Investigating the role of early childhood abuse and HPA axis genes in suicide attempters with bipolar disorder"],"prefix":"10.1097","volume":"25","author":[{"given":"Marie E.","family":"Breen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fayaz","family":"Seifuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter P.","family":"Zandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Potash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia L.","family":"Willour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-2-20210213","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1601-183X.2011.00703.x","article-title":"Gene-environment interactions between CRHR1 variants and physical assault in suicide attempts.","volume":"10","author":"Ben-Efraim","year":"2011","journal-title":"Genes Brain Behav"},{"key":"R2-2-20210213","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/mp.2012.86","article-title":"Family-based study of HTR2A in suicide attempts: observed gene, gene x environment and parent-of-origin associations.","volume":"18","author":"Ben-Efraim","year":"2013","journal-title":"Mol Psychiatry"},{"issue":"Suppl 1","key":"R4-2-20210213","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1016\/j.psyneuen.2009.05.021","article-title":"The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders.","volume":"34","author":"Binder","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"R5-2-20210213","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.psyneuen.2012.05.001","article-title":"Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner.","volume":"38","author":"Bourke","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"R6-2-20210213","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ajmg.c.30042","article-title":"Family genetic studies, suicide, and suicidal behavior.","volume":"133C","author":"Brent","year":"2005","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"R7-2-20210213","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.psc.2008.02.001","article-title":"Familial transmission of suicidal behavior.","volume":"31","author":"Brent","year":"2008","journal-title":"Psychiatr Clin North Am"},{"key":"R9-2-20210213","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.psc.2008.01.008","article-title":"The genetics of suicide: a critical review of molecular studies.","volume":"31","author":"Brezo","year":"2008","journal-title":"Psychiatr Clin North Am"},{"key":"R10-2-20210213","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1192\/bjp.bp.107.037994","article-title":"Predicting suicide attempts in young adults with histories of childhood abuse.","volume":"193","author":"Brezo","year":"2008","journal-title":"Br J Psychiatry"},{"key":"R11-2-20210213","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.psc.2008.02.002","article-title":"Adverse childhood experiences and suicidal behavior.","volume":"31","author":"Brodsky","year":"2008","journal-title":"Psychiatr Clin North Am"},{"key":"R13-2-20210213","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0092-8674(83)90430-0","article-title":"DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo.","volume":"33","author":"Chandler","year":"1983","journal-title":"Cell"},{"key":"R14-2-20210213","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1176\/ajp.138.8.1120","article-title":"Suicide and the dexamethasone suppression test in unipolar depression.","volume":"138","author":"Coryell","year":"1981","journal-title":"Am J Psychiatry"},{"key":"R16-2-20210213","first-page":"1","article-title":"Suicidal thoughts and behaviors among adults aged 18 years - United States, 2008-2009.","volume":"60","author":"Crosby","year":"2011","journal-title":"MMWR Surveill Summ"},{"key":"R17-2-20210213","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1074\/jbc.C100531200","article-title":"A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins.","volume":"277","author":"Davies","year":"2002","journal-title":"J Biol Chem"},{"key":"R18-2-20210213","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.eurpsy.2006.12.001","article-title":"Association study between the corticotropin-releasing hormone receptor 2 gene and suicidality in bipolar disorder.","volume":"22","author":"De Luca","year":"2007","journal-title":"Eur Psychiatry"},{"key":"R21-2-20210213","doi-asserted-by":"crossref","first-page":"T29","DOI":"10.1530\/JME-14-0050","article-title":"Molecular evolution of GPCRs: melanocortinmelanocortin receptors.","volume":"52","author":"Dores","year":"2014","journal-title":"J Mol Endocrinol"},{"key":"R22-2-20210213","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1017\/S0033291706008646","article-title":"Childhood adversities and risk for suicidal ideation and attempts: a longitudinal population-based study.","volume":"36","author":"Enns","year":"2006","journal-title":"Psychol Med"},{"key":"R23-2-20210213","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2007.05.018","article-title":"The glucocorticoid responses are shaped by molecular chaperones.","volume":"275","author":"Grad","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"R25-2-20210213","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.psyneuen.2008.03.008","article-title":"The link between childhood trauma and depression: insights from HPA axis studies in humans.","volume":"33","author":"Heim","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"R26-2-20210213","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mce.2008.10.041","article-title":"Structure and function of the melanocortin2 receptor accessory protein (MRAP).","volume":"300","author":"Hinkle","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"R28-2-20210213","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1379\/1466-1268(2001)006<0078:ROTHBI>2.0.CO;2","article-title":"Regulation of the Hsp90-binding immunophilin, cyclophilin 40, is mediated by multiple sites for GA-binding protein (GABP).","volume":"6","author":"Kumar","year":"2001","journal-title":"Cell Stress Chaperones"},{"key":"R29-2-20210213","doi-asserted-by":"crossref","first-page":"207361","DOI":"10.1155\/2013\/207361","article-title":"Association, haplotype, and gene-gene interactions of the HPA axis genes with suicidal behaviour in affective disorders.","volume":"2013","author":"Leszczynska-Rodziewicz","year":"2013","journal-title":"ScientificWorldJournal"},{"key":"R33-2-20210213","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1210\/endo.141.6.7489","article-title":"Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary.","volume":"141","author":"Meijer","year":"2000","journal-title":"Endocrinology"},{"key":"R37-2-20210213","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1001\/archpsyc.1988.01800300075009","article-title":"Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.","volume":"45","author":"Nemeroff","year":"1988","journal-title":"Arch Gen Psychiatry"},{"key":"R39-2-20210213","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1126\/science.270.5240.1354","article-title":"Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.","volume":"270","author":"Onate","year":"1995","journal-title":"Science"},{"key":"R40-2-20210213","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0006-291X(87)91369-6","article-title":"Specific high-affinity binding protein for human corticotropin-releasing hormone in normal human plasma.","volume":"143","author":"Orth","year":"1987","journal-title":"Biochem Biophys Res Commun"},{"key":"R41-2-20210213","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies.","volume":"38","author":"Price","year":"2006","journal-title":"Nat Genet"},{"key":"R43-2-20210213","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1471-4892(01)00117-5","article-title":"Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression.","volume":"2","author":"Reul","year":"2002","journal-title":"Curr Opin Pharmacol"},{"key":"R44-2-20210213","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/npp.2009.236","article-title":"Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide.","volume":"35","author":"Roy","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"R45-2-20210213","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jpsychires.2011.09.009","article-title":"Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior.","volume":"46","author":"Roy","year":"2012","journal-title":"J Psychiatr Res"},{"key":"R50-2-20210213","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.6267699","article-title":"Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin.","volume":"213","author":"Vale","year":"1981","journal-title":"Science"},{"key":"R51-2-20210213","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1601-183X.2007.00310.x","article-title":"The CRHR1 gene: a marker for suicidality in depressed males exposed to low stress.","volume":"7","author":"Wasserman","year":"2008","journal-title":"Genes Brain Behav"},{"key":"R52-2-20210213","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1601-183X.2008.00446.x","article-title":"Depression in suicidal males: genetic risk variants in the CRHR1 gene.","volume":"8","author":"Wasserman","year":"2009","journal-title":"Genes Brain Behav"},{"key":"R54-2-20210213","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1210\/en.2005-0751","article-title":"Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis function.","volume":"147","author":"Winnay","year":"2006","journal-title":"Endocrinology"}],"container-title":["Psychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/YPG.0000000000000082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T01:26:17Z","timestamp":1747704377000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00041444-201506000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1097\/ypg.0000000000000082","relation":{},"ISSN":["0955-8829"],"issn-type":[{"value":"0955-8829","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}