{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T22:23:34Z","timestamp":1769379814585,"version":"3.49.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n            <jats:title>Purpose of review<\/jats:title>\n            <jats:p>Beta-lactam allergy is frequently reported, but only a minority of cases correspond to true allergies. Tools to stratify the risk of a real allergic reaction can possibly help delabeling patients. We aimed to retrieve evidence on algorithms for risk stratification of patients with a beta-lactam allergy label.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Recent findings<\/jats:title>\n            <jats:p>We performed a systematic review, searching three databases and included 28 studies. Most of the applied tools involved the assessment of the presence of rash\/hives\/other exanthemas (<jats:italic toggle=\"yes\">n<\/jats:italic>\u200a=\u200a24), angioedema\/localized swelling (<jats:italic toggle=\"yes\">n<\/jats:italic>\u200a=\u200a23), bronchospasm\/wheezing\/dyspnea (<jats:italic toggle=\"yes\">n<\/jats:italic>\u200a=\u200a22) and gastrointestinal symptoms (<jats:italic toggle=\"yes\">n<\/jats:italic>\u200a=\u200a21). Seventeen studies classified participants into different categories according to their risk of having a penicillin allergy; three studies presented algorithms indicating management approaches to be followed; six studies applied predictive models. Most studies had a high risk of bias, particularly concerning the reference standard and lack of external validation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary<\/jats:title>\n            <jats:p>Existing algorithms for beta-lactam allergy risk stratification are very heterogeneous and most of them lack validation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/aci.0000000000001086","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T14:00:13Z","timestamp":1750428013000},"page":"247-257","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Algorithms for the classification of patients with a \u03b2-lactam allergy label: a systematic review"],"prefix":"10.1097","volume":"25","author":[{"given":"Joana","family":"Sousa","sequence":"first","affiliation":[{"name":"MEDCIDS \u2013 Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto"},{"name":"USF Campos do Mondego, ULS Baixo Mondego"}]},{"given":"Joana","family":"Balseiro","sequence":"additional","affiliation":[{"name":"USF Terras de Cantanhede"}]},{"given":"Mariana","family":"Barreto","sequence":"additional","affiliation":[{"name":"USF S\u00e3o Marcos do Mondego, ULS Coimbra"}]},{"given":"Francisca","family":"Mendes","sequence":"additional","affiliation":[{"name":"USF S\u00e3o Marcos do Mondego, ULS Coimbra"}]},{"given":"Ana Margarida","family":"Pereira","sequence":"additional","affiliation":[{"name":"MEDCIDS \u2013 Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto"},{"name":"CINTESIS@RISE \u2013 Centre for Health Technology and Services Research, Health Research Network, Faculty of Medicine, University of Porto"},{"name":"Allergy Unit, CUF-Porto Hospital and Institute, Porto, Portugal"}]},{"given":"In\u00eas","family":"Ribeiro-Vaz","sequence":"additional","affiliation":[{"name":"MEDCIDS \u2013 Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto"},{"name":"CINTESIS@RISE \u2013 Centre for Health Technology and Services Research, Health Research Network, Faculty of Medicine, University of Porto"}]},{"given":"Ricardo","family":"Cruz-Correia","sequence":"additional","affiliation":[{"name":"MEDCIDS \u2013 Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto"},{"name":"CINTESIS@RISE \u2013 Centre for Health Technology and Services Research, Health Research Network, Faculty of Medicine, University of Porto"}]},{"given":"Bernardo","family":"Sousa-Pinto","sequence":"additional","affiliation":[{"name":"MEDCIDS \u2013 Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of 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