{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:05:58Z","timestamp":1776297958627,"version":"3.50.1"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate if psychological\/cognitive aspects and executive functions can influence conditioned pain modulation (CPM) activity in elderly people with and without chronic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A cross-sectional unifactorial repeated measures case-control study with 19 adults (89.5% women, age: 73.2\u00b15.6\u00a0y) with chronic primary musculoskeletal pain and 38 adults (74.5% women, age: 74.3\u00b14.4\u00a0y) without chronic pain was conducted. Pain features, psychological\/cognitive (anxiety, depression, pain hypervigilance, and pain catastrophizing), and 2 executive functions (working memory, mental inhibition) were assessed. Subsequently, CPM was evaluated on changes obtained in mechanical (pressure pain threshold\u2014PPT) stimuli with the cold-pressor test paradigm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A significant group X time interaction after controlling all cofounders was found: PPTs were higher after the conditioned stimulus in individuals without chronic pain (CPM increase 15%\u00b110%), whereas PPTs were lower after the conditioned stimulus in those with chronic pain (CPM decrease \u221211%\u00b17%) when compared with PPTs at baseline. In elderly people with chronic pain, pain intensity and catastrophizing accounted for 28.6% of the variance of the CPM activation index. In elderly people without chronic pain, just pain catastrophizing had significant predictive value accounting for 10.6% of the variance of CPM activation index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Elderly people with chronic musculoskeletal pain exhibited impaired CPM activation as compared with adults without chronic pain. Thus, CPM activation was associated with the intensity of pain and, in a lesser extent, with pain catastrophizing, but not with anxiety\/depressive levels and executive functions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/ajp.0000000000001366","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T10:00:09Z","timestamp":1772013609000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Influence of Pain Intensity and Pain Catastrophizing on Conditioned Pain Modulation in Elderly People With and Without Chronic Pain"],"prefix":"10.1097","volume":"42","author":[{"given":"Francisco G.","family":"Fern\u00e1ndez-Palacios","sequence":"first","affiliation":[{"name":"Department of Research and Psychology in Education, Universidad Complutense de Madrid, Madrid, 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