{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:59:58Z","timestamp":1771469998399,"version":"3.50.1"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1097\/cad.0b013e32834438f6","type":"journal-article","created":{"date-parts":[[2011,4,28]],"date-time":"2011-04-28T06:54:11Z","timestamp":1303973651000},"page":"507-518","source":"Crossref","is-referenced-by-count":44,"title":["Involvement of mitochondrial and B-RAF\/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells"],"prefix":"10.1097","volume":"22","author":[{"given":"Ana","family":"Burgeiro","sequence":"first","affiliation":[]},{"given":"Consuelo","family":"Gajate","sequence":"additional","affiliation":[]},{"given":"EL Habib","family":"Dakir","sequence":"additional","affiliation":[]},{"given":"Janny A.","family":"Villa-Pulgar\u00edn","sequence":"additional","affiliation":[]},{"given":"Paulo J.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Faustino","family":"Mollinedo","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"key":"R1-5-20210203","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/ptr.2399","article-title":"Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine.","volume":"22","author":"Imanshahidi","year":"2008","journal-title":"Phytother Res"},{"key":"R2-5-20210203","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.phrs.2007.06.003","article-title":"Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells.","volume":"56","author":"Lee","year":"2007","journal-title":"Pharmacol Res"},{"key":"R3-5-20210203","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jbbm.2007.07.009","article-title":"Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by microcalorimetry.","volume":"70","author":"Yan","year":"2008","journal-title":"J Biochem Biophys Methods"},{"key":"R4-5-20210203","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nm1135","article-title":"Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.","volume":"10","author":"Kong","year":"2004","journal-title":"Nat Med"},{"key":"R5-5-20210203","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/db07-1552","article-title":"Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action.","volume":"57","author":"Turner","year":"2008","journal-title":"Diabetes"},{"key":"R6-5-20210203","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.bmcl.2006.12.085","article-title":"Antiviral activity of berberine and related compounds against human cytomegalovirus.","volume":"17","author":"Hayashi","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"R7-5-20210203","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejphar.2007.05.002","article-title":"Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride.","volume":"569","author":"Kulkarni","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"R8-5-20210203","first-page":"4063","article-title":"Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells.","volume":"29","author":"Ho","year":"2009","journal-title":"Anticancer Res"},{"key":"R9-5-20210203","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.phymed.2009.02.015","article-title":"Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model.","volume":"16","author":"Ho","year":"2009","journal-title":"Phytomedicine"},{"key":"R10-5-20210203","doi-asserted-by":"crossref","first-page":"27456","DOI":"10.1074\/jbc.M109.033795","article-title":"Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at threonine 567.","volume":"284","author":"Tang","year":"2009","journal-title":"J Biol Chem"},{"key":"R11-5-20210203","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.phymed.2009.08.012","article-title":"The alkaloid Berberine inhibits the growth of Anoikis-resistant MCF-7 and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest.","volume":"17","author":"Kim","year":"2009","journal-title":"Phytomedicine"},{"key":"R12-5-20210203","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/jcb.22198","article-title":"The combination of berberine and irradiation enhances anti-cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells.","volume":"107","author":"Hur","year":"2009","journal-title":"J Cell Biochem"},{"key":"R13-5-20210203","first-page":"1221","article-title":"Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells.","volume":"34","author":"Choi","year":"2009","journal-title":"Int J Oncol"},{"key":"R14-5-20210203","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mrfmmm.2008.12.009","article-title":"Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage.","volume":"662","author":"Liu","year":"2009","journal-title":"Mutat Res"},{"key":"R16-5-20210203","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3748\/wjg.v12.i1.21","article-title":"Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line.","volume":"12","author":"Lin","year":"2006","journal-title":"World J Gastroenterol"},{"key":"R17-5-20210203","first-page":"3777","article-title":"Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis.","volume":"28","author":"Choi","year":"2008","journal-title":"Anticancer Res"},{"key":"R18-5-20210203","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1248\/bpb.31.558","article-title":"Berberine induces G1 arrest and apoptosis in human glioblastoma T98G cells through mitochondrialcaspases pathway.","volume":"31","author":"Eom","year":"2008","journal-title":"Biol Pharm Bull"},{"key":"R19-5-20210203","first-page":"1681","article-title":"Involvement of reactive oxygen species and caspase-dependent pathway in berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cells.","volume":"34","author":"Chen","year":"2009","journal-title":"Int J Oncol"},{"key":"R20-5-20210203","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.canlet.2005.08.024","article-title":"Berberine-antiproliferative activity in vitro and induction of apoptosisnecrosis of the U937 and B16 cells.","volume":"239","author":"Letasiova","year":"2006","journal-title":"Cancer Lett"},{"key":"R21-5-20210203","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s00280-007-0558-9","article-title":"Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line.","volume":"61","author":"Serafim","year":"2008","journal-title":"Cancer Chemother Pharmacol"},{"key":"R22-5-20210203","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1124\/jpet.107.128017","article-title":"Mitochondrially targeted effects of berberine Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.","volume":"323","author":"Pereira","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"R23-5-20210203","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/toxsci\/kfn131","article-title":"Mechanisms of berberine (natural yellow 18)-induced mitochondrial dysfunction: interaction with the adenine nucleotide translocator.","volume":"105","author":"Pereira","year":"2008","journal-title":"Toxicol Sci"},{"key":"R24-5-20210203","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1056\/NEJMra052166","article-title":"Melanoma.","volume":"355","author":"Miller","year":"2006","journal-title":"N Engl J Med"},{"key":"R26-5-20210203","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10863-006-9056-8","article-title":"Chemotherapy through mitochondrial apoptosis using nutritional supplements and herbs: a brief overview.","volume":"39","author":"Kwon","year":"2007","journal-title":"J Bioenerg Biomembr"},{"key":"R27-5-20210203","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1093\/carcin\/bgl043","article-title":"Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP.","volume":"27","author":"Mantena","year":"2006","journal-title":"Carcinogenesis"},{"key":"R28-5-20210203","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1158\/1535-7163.MCT-05-0448","article-title":"Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells.","volume":"5","author":"Mantena","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"R29-5-20210203","first-page":"1097","article-title":"Down-regulation of cyclin B1 and up-regulation of Wee1 by berberine promotes entry of leukemia cells into the G2M-phase of the cell cycle.","volume":"26","author":"Lin","year":"2006","journal-title":"Anticancer Res"},{"key":"R30-5-20210203","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/(SICI)1097-0215(20000415)86:2<208::AID-IJC10>3.0.CO;2-E","article-title":"Involvement of mitochondria and caspase-3 in ET-18-OCH3-induced apoptosis of human leukemic cells.","volume":"86","author":"Gajate","year":"2000","journal-title":"Int J Cancer"},{"key":"R31-5-20210203","first-page":"1535","article-title":"Rapid and selective apoptosis in human leukemic cells induced by aplidine through a FasCD95- and mitochondrial-mediated mechanism.","volume":"9","author":"Gajate","year":"2003","journal-title":"Clin Cancer Res"},{"key":"R32-5-20210203","first-page":"1320","article-title":"Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-XL.","volume":"57","author":"Mollinedo","year":"1997","journal-title":"Cancer Res"},{"key":"R34-5-20210203","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1083\/jcb.200212059","article-title":"Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol.","volume":"160","author":"Breckenridge","year":"2003","journal-title":"J Cell Biol"},{"key":"R35-5-20210203","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1073\/pnas.94.13.6939","article-title":"Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis.","volume":"94","author":"Kharbanda","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R36-5-20210203","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1182\/blood-2006-04-016824","article-title":"Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.","volume":"109","author":"Gajate","year":"2007","journal-title":"Blood"},{"key":"R37-5-20210203","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ccr.2007.03.009","article-title":"Rewired ERK-JNK signaling pathways in melanoma.","volume":"11","author":"Lopez-Bergami","year":"2007","journal-title":"Cancer Cell"},{"key":"R38-5-20210203","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1136\/jcp.2005.025957","article-title":"Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma.","volume":"58","author":"Zhuang","year":"2005","journal-title":"J Clin Pathol"},{"key":"R39-5-20210203","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1158\/0008-5472.CAN-07-2038","article-title":"Is B-Raf a good therapeutic target for melanoma and other malignancies.","volume":"68","author":"Madhunapantula","year":"2008","journal-title":"Cancer Res"},{"key":"R40-5-20210203","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.2174\/092986709789378206","article-title":"Apoptosis and human diseases: mitochondrion damage and lethal role of released cytochrome C as proapoptotic protein.","volume":"16","author":"Caroppi","year":"2009","journal-title":"Curr Med Chem"},{"key":"R41-5-20210203","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejphar.2010.07.037","article-title":"Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway.","volume":"645","author":"Patil","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"R42-5-20210203","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/carcin\/bgn220","article-title":"Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells.","volume":"30","author":"Jiang","year":"2009","journal-title":"Carcinogenesis"},{"key":"R43-5-20210203","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/S0006-2952(02)00982-6","article-title":"Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid.","volume":"63","author":"Kang","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"R44-5-20210203","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1158\/0008-5472.CAN-08-0511","article-title":"Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.","volume":"68","author":"Pandey","year":"2008","journal-title":"Cancer Res"},{"key":"R45-5-20210203","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/pros.20899","article-title":"Butanol fraction containing berberine or related compound from nexrutine inhibits NF-kappaB signaling and induces apoptosis in prostate cancer cells.","volume":"69","author":"Muralimanoharan","year":"2009","journal-title":"Prostate"},{"key":"R46-5-20210203","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ejphar.2010.04.033","article-title":"Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury.","volume":"638","author":"Liu","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"R47-5-20210203","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.bcp.2005.06.016","article-title":"Activation of the aryl hydrocarbon receptor by berberine in HepG2 and H4IIE cells: biphasic effect on CYP1A1.","volume":"70","author":"Vrzal","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"R48-5-20210203","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1124\/mol.104.005223","article-title":"The aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis.","volume":"67","author":"Park","year":"2005","journal-title":"Mol Pharmacol"},{"key":"R49-5-20210203","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1091\/mbc.e08-04-0359","article-title":"The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis.","volume":"19","author":"Marlowe","year":"2008","journal-title":"Mol Biol Cell"},{"key":"R50-5-20210203","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1124\/mol.53.3.438","article-title":"PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.","volume":"53","author":"Reiners","year":"1998","journal-title":"Mol Pharmacol"},{"key":"R51-5-20210203","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.2741\/1755","article-title":"The RASRAFMEKERK and PI3KAKT signaling pathways present molecular targets for the effective treatment of advanced melanoma.","volume":"10","author":"Meier","year":"2005","journal-title":"Front Biosci"},{"key":"R52-5-20210203","first-page":"756","article-title":"Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation.","volume":"63","author":"Satyamoorthy","year":"2003","journal-title":"Cancer Res"},{"key":"R53-5-20210203","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nature00766","article-title":"Mutations of the BRAF gene in human cancer.","volume":"417","author":"Davies","year":"2002","journal-title":"Nature"},{"key":"R54-5-20210203","first-page":"6997","article-title":"BRAF and RAS mutations in human lung cancer and melanoma.","volume":"62","author":"Brose","year":"2002","journal-title":"Cancer Res"},{"key":"R55-5-20210203","doi-asserted-by":"crossref","first-page":"11100","DOI":"10.1158\/0008-5472.CAN-06-2554","article-title":"Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.","volume":"66","author":"King","year":"2006","journal-title":"Cancer Res"}],"container-title":["Anti-Cancer Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/CAD.0b013e32834438f6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T23:15:56Z","timestamp":1620947756000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00001813-201107000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/cad.0b013e32834438f6","relation":{},"ISSN":["0959-4973"],"issn-type":[{"value":"0959-4973","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}