{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:57:08Z","timestamp":1773925028661,"version":"3.50.1"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Portugal has the highest gastric cancer mortality rates in Western Europe, along with high prevalences of <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic> infection. Monitoring their trends is essential to predict the burden of this cancer. We aimed to quantify time trends in gastric cancer mortality in Portugal and in each administrative region, and to compute short-term predictions, as well as to describe the prevalence of <jats:italic toggle=\"yes\">H. pylori<\/jats:italic> infection, through a systematic review. Joinpoint analyses were used to identify significant changes in sex-specific trends in gastric cancer age-standardized mortality rates (ASMR) and to estimate annual percent changes (APC). The most recent trends were considered to compute estimates up to 2020 by adjusting Poisson regression models. We searched PubMed and IndexRMP to identify studies carried out in Portugal reporting the prevalence <jats:italic toggle=\"yes\">of H. pylori<\/jats:italic>. Gastric cancer mortality has been decreasing in Portugal since 1971 in men (from ASMR=55.3\/100\u2009000; APC=\u22122.4, 95% confidence interval: \u22122.5 to \u22122.3) and since 1970 in women (from ASMR=28.0\/100\u2009000; APC=\u22122.8, 95% confidence interval: \u22122.9 to \u22122.7), although large regional differences were observed. Predicted ASMR for 2015 and 2020 were 18.8\/100\u2009000 and 16.7\/100\u2009000 for men and 8.5\/100\u2009000 and 7.4\/100\u2009000 for women, respectively. The prevalence of <jats:italic toggle=\"yes\">H. pylori<\/jats:italic> varied from almost 5% at 0.5\u20132 years to just over 90% at 70 years or more. No consistent variation was observed since the 1990s. The downward trends in mortality rates are expected to remain in the next decades. The high prevalence of <jats:italic toggle=\"yes\">H. pylori<\/jats:italic> infection across age groups and studies from different periods shows a large potential for decrease in the burden of gastric cancer in Portugal.<\/jats:p>","DOI":"10.1097\/cej.0000000000000183","type":"journal-article","created":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T13:48:32Z","timestamp":1437140912000},"page":"275-281","source":"Crossref","is-referenced-by-count":37,"title":["Trends in gastric cancer mortality and in the prevalence of Helicobacter pylori infection in Portugal"],"prefix":"10.1097","volume":"25","author":[{"given":"Samantha","family":"Morais","sequence":"first","affiliation":[{"name":"EPIUnit \u2013 Institute of Public Health, University of Porto"}]},{"given":"Ana","family":"Ferro","sequence":"additional","affiliation":[{"name":"EPIUnit \u2013 Institute of Public Health, University of Porto"}]},{"given":"Ana","family":"Bastos","sequence":"additional","affiliation":[{"name":"EPIUnit \u2013 Institute of Public Health, University of Porto"}]},{"given":"Clara","family":"Castro","sequence":"additional","affiliation":[{"name":"EPIUnit \u2013 Institute of Public Health, University of Porto"},{"name":"North Region Cancer Registry (RORENO) \u2013 Portuguese Oncology Institute"}]},{"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[{"name":"EPIUnit \u2013 Institute of Public Health, University of Porto"},{"name":"Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal"}]},{"given":"B\u00e1rbara","family":"Peleteiro","sequence":"additional","affiliation":[{"name":"EPIUnit \u2013 Institute of Public Health, University of Porto"},{"name":"Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal"}]}],"member":"276","reference":[{"key":"R1-20230901","first-page":"90","article-title":"[Infec\u00e7\u00e3o por 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