{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T14:04:15Z","timestamp":1765461855224,"version":"3.48.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","funder":[{"name":"FCT","award":["UIDB\/04750\/2020"],"award-info":[{"award-number":["UIDB\/04750\/2020"]}]},{"name":"FCT","award":["LA\/P\/0064\/2020"],"award-info":[{"award-number":["LA\/P\/0064\/2020"]}]},{"name":"FCT","award":["POCI-01-0145-FEDER-032358; ref. PTDC\/SAU-EPI\/32358\/2017"],"award-info":[{"award-number":["POCI-01-0145-FEDER-032358; ref. PTDC\/SAU-EPI\/32358\/2017"]}]},{"name":"FCT","award":["UIDP\/04750\/2020"],"award-info":[{"award-number":["UIDP\/04750\/2020"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    The growing number of cancer survivors has led to an increase in the frequency of multiple primary cancers. This study aimed to describe the temporal trends in the incidence rates and standardized incidence ratios (SIRs) of second primary cancers (SPCs) among patients diagnosed with a first primary cancer (FPC) in 2000\u201303, 2004\u201307 and 2008\u201311 in Northern Portugal. Population-based samples of patients diagnosed with an FPC (excluding skin non-melanoma) in 3 periods of 4 years, between 1 January 2000 and 31 December 2011, and registered in the Portuguese North Region Cancer Registry were followed for the diagnosis of an SPC or death until 31 December 2013. Incidence rates and SIRs were estimated for each period by sex, and considering the time between FPC and SPC diagnosis (synchronous and metachronous). During follow-up, 10\u2005119 (7.4%) SPCs were identified among patients diagnosed with an FPC in 2000\u201311 (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2005=\u2005136\u2005382). The incidence rate of SPCs was over 10-fold higher in the first few months, remaining stable over the follow-up. Higher rates were observed in 2004\u201307 and 2008\u201311. Overall, a greater proportion of SPCs was diagnosed among males than females. The proportion of SPCs diagnosed increased with age. Increases in SIRs of SPCs were observed from 2000\u201303 to 2008\u201311, ranging from 1.16 to 1.77 and from 1.54 to 2.33, among males and females, respectively. This was particularly evident for FPCs and SPCs of the lip, oral cavity, pharynx, oesophagus and larynx among males, and colon and rectum, lung, ovary and cervix among females. Survivors of cancer in Northern Portugal had higher incidence rates of cancer than the general population, which have increased over time. Our findings highlight the need for enhanced surveillance and tailored strategies for survivors of cancer, emphasizing the challenges of their heightened cancer risk, patient expectations, and associated economic burden.\n                  <\/jats:p>","DOI":"10.1097\/cej.0000000000000962","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T12:00:26Z","timestamp":1740744026000},"page":"10-20","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Temporal trends in the incidence of second primary cancers in Northern Portugal: a population-based study"],"prefix":"10.1097","volume":"35","author":[{"given":"Elisabete","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"EPIUnit \u2013 Instituto de Sa\u00fade P\u00fablica, Universidade do Porto"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR)"}]},{"given":"Filipa","family":"Fontes","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina da Universidade do Porto"},{"name":"Grupo de Abordagem de Les\u00f5es Pr\u00e9-Cancerosas e Cancro Precoce"}]},{"given":"J\u00e9ssica Rocha","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Grupo de Investiga\u00e7\u00e3o em Epidemiologia, Resultados, Economia e Gest\u00e3o em Oncologia \u2013 Centro de Investiga\u00e7\u00e3o (CI-IPOP) & Porto Comprehensive Cancer Center (Porto.CCC) & RISE@CI-IPOP (Rede de Investiga\u00e7\u00e3o em Sa\u00fade)"},{"name":"Servi\u00e7o de Epidemiologia, Instituto Portugu\u00eas de Oncologia do Porto FG, EPE (IPO-Porto)"}]},{"given":"Luis","family":"Antunes","sequence":"additional","affiliation":[{"name":"Grupo de Investiga\u00e7\u00e3o em Epidemiologia, Resultados, Economia e Gest\u00e3o em Oncologia \u2013 Centro de Investiga\u00e7\u00e3o (CI-IPOP) & Porto Comprehensive Cancer Center (Porto.CCC) & RISE@CI-IPOP (Rede de Investiga\u00e7\u00e3o em Sa\u00fade)"}]},{"given":"Maria Jos\u00e9","family":"Bento","sequence":"additional","affiliation":[{"name":"Grupo de Investiga\u00e7\u00e3o em Epidemiologia, Resultados, Economia e Gest\u00e3o em Oncologia \u2013 Centro de Investiga\u00e7\u00e3o (CI-IPOP) & Porto Comprehensive Cancer Center (Porto.CCC) & RISE@CI-IPOP (Rede de Investiga\u00e7\u00e3o em Sa\u00fade)"},{"name":"Servi\u00e7o de Epidemiologia, Instituto Portugu\u00eas de Oncologia do Porto FG, EPE (IPO-Porto)"},{"name":"Departamento de Estudos de Popula\u00e7\u00f5es, ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal"}]},{"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[{"name":"EPIUnit \u2013 Instituto de Sa\u00fade P\u00fablica, Universidade do Porto"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR)"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina da Universidade do Porto"}]},{"given":"Samantha","family":"Morais","sequence":"additional","affiliation":[{"name":"EPIUnit \u2013 Instituto de Sa\u00fade P\u00fablica, Universidade do Porto"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR)"}]}],"member":"276","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"R1-20251211","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/ijc.32101","article-title":"Trends in the risk and burden of second primary malignancy among survivors of smoking-related cancers in the United States.","volume":"145","author":"Adjei Boakye","year":"2019","journal-title":"Int J 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