{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:28:22Z","timestamp":1772612902206,"version":"3.50.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>Adherence to treatment regimen and schedule is recommended to improve control of disease and overall survival (OS) in locally advanced cervical cancer. However, treatment-related toxicities and patient and physician factors all impact timely completion of treatment. We sought to correlate adherence to treatment plan with survival and toxicities of patients treated for locally advanced cervical cancer.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods:<\/jats:title>\n            <jats:p>A retrospective review of patients treated for advanced cervical cancer at our institution between 2003 and 2011 was performed. Demographics, clinicopathologic variables, treatment, and disease outcomes were collected. Endpoints of disease outcome were disease-free survival and OS. Statistical analyses were performed using the Kaplan-Meier method, log-rank test, and Cox regression analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A total of 162 patients met the inclusion criteria and were included in study analysis. A total of 95% of patients were treated with both radiation and concurrent chemotherapy. Mean radiation dose to point A was 72 Gy. In total, 77% had complete response to primary therapy. Severe (grade 3\/4) late radiation toxicities were seen in 10.5% of patients. Stage and total radiation dose to point A were significant predictors of survival for the entire cohort. Among patients receiving at least 72 Gy and brachytherapy, duration of treatment was significantly associated with both disease-free survival and OS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Adherence to both optimal treatment time and radiation dose is significantly associated with improved survival. Total radiation dose is an independent predictor of survival among patients with locally advanced cervical cancer.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/coc.0000000000000300","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T12:07:28Z","timestamp":1464955648000},"page":"447-451","source":"Crossref","is-referenced-by-count":7,"title":["Locally Advanced Cervical Cancer"],"prefix":"10.1097","volume":"41","author":[{"given":"Dustin B.","family":"Manders","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology, Division of Gynecologic Oncology"}]},{"given":"Abel","family":"Mor\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, SUNY Downstate Medical Center, Brooklyn, NY"}]},{"given":"Donald","family":"McIntire","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology"}]},{"given":"David S.","family":"Miller","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Division of Gynecologic Oncology"}]},{"given":"Debra L.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Division of Gynecologic Oncology"}]},{"given":"Siobhan M.","family":"Kehoe","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Division of Gynecologic Oncology"}]},{"given":"Kevin V.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX"}]},{"given":"Jayanthi S.","family":"Lea","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Division of Gynecologic Oncology"}]}],"member":"276","reference":[{"key":"R1-20230903","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1016\/j.ejca.2013.04.024","article-title":"Worldwide trends in cervical cancer incidence: impact of screening against changes in disease risk factors","volume":"49","author":"Vaccarella","year":"2013","journal-title":"Eur J Cancer"},{"key":"R2-20230903","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0167-8140(03)00197-X","article-title":"A systematic review of acute and late toxicity of concomitant chemoradiation for cervical cancer","volume":"68","author":"Kirwan","year":"2003","journal-title":"Radiother Oncol"},{"key":"R3-20230903","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"R4-20230903","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0167-8140(92)90247-R","article-title":"The effect of treatment duration in the local control of cervix cancer","volume":"25","author":"Fyles","year":"1992","journal-title":"Radiother Oncol"},{"key":"R5-20230903","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ygyno.2006.12.027","article-title":"Which clinical\/pathologic factors matter in the era of chemoradiation as treatment for locally advanced cervical carcinoma? Analysis of two Gynecologic Oncology Group (GOG) trials","volume":"105","author":"Monk","year":"2007","journal-title":"Gynecol Oncol"},{"key":"R6-20230903","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/cncr.27652","article-title":"The effect of treatment time in locally advanced cervical cancer in the era of concurrent chemoradiotherapy","volume":"119","author":"Song","year":"2013","journal-title":"Cancer"},{"key":"R7-20230903","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1080\/02841860410018511","article-title":"Influence of overall treatment time and radiobiological parameters on biologically effective doses in cervical cancer patients treated with radiation therapy alone","volume":"43","author":"Gasinska","year":"2004","journal-title":"Acta Oncol"},{"key":"R8-20230903","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ijrobp.2013.01.037","article-title":"Effects of treatment duration during concomitant chemoradiation therapy for cervical cancer","volume":"86","author":"Shaverdian","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R9-20230903","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/S0020-7292(06)60030-1","article-title":"Carcinoma of the cervix uteri","volume":"95","author":"Quinn","year":"2006","journal-title":"Int J Gynecol Obstet"},{"key":"R10-20230903","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ijrobp.2013.05.033","article-title":"Trends in the utilization of brachytherapy in cervical cancer in the United States","volume":"87","author":"Han","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R11-20230903","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.ijrobp.2014.07.017","article-title":"National Cancer Data Base analysis of radiation therapy consolidation modality for cervical cancer: the impact of new technological advancements","volume":"90","author":"Gill","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R12-20230903","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/gyno.1993.1132","article-title":"Dose-tumor response for carcinoma of cervix: an analysis of 594 patients treated by radiotherapy","volume":"49","author":"Choy","year":"1993","journal-title":"Gynecol Oncol"},{"key":"R13-20230903","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/S0360-3016(03)00288-8","article-title":"Combination external beam radiotherapy and high-dose-rate intracavitary brachytherapy for uterine cervical cancer: analysis of dose and fraction schedule","volume":"56","author":"Toita","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R14-20230903","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/0360-3016(95)00220-S","article-title":"Carcinoma of the uterine cervix. 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Impact of prolongation of overall treatment time and timing of brachytherapy on outcome of radiation therapy","volume":"32","author":"Perez","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R15-20230903","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1200\/JCO.2004.07.197","article-title":"Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01","volume":"22","author":"Eifel","year":"2004","journal-title":"J Clin Oncol"},{"key":"R16-20230903","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.clon.2008.03.001","article-title":"Long-term survival and late toxicity after chemoradiotherapy for cervical cancer\u2014the Addenbrooke\u2019s experience","volume":"20","author":"Tan","year":"2008","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"R17-20230903","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ijrobp.2012.05.033","article-title":"Outcomes of high-dose-rate interstitial brachytherapy in the treatment of locally advanced cervical cancer: long-term results","volume":"85","author":"Pinn-Bingham","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R18-20230903","first-page":"504","article-title":"Late toxicities in concurrent chemoradiotherapy using high-dose-rate intracavitary brachytherapy plus weekly cisplatin for locally advanced cervical cancer: a historical cohort comparison against two previous different treatment schemes","volume":"31","author":"Chen","year":"2010","journal-title":"Eur J Gynaecol Oncol"},{"key":"R19-20230903","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0360-3016(95)00169-7","article-title":"Carcinoma of the uterine cervix. 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Lack of impact of prolongation of overall treatment time on morbidity of radiation therapy","volume":"34","author":"Perez","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["American Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00000421-201805000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T03:03:19Z","timestamp":1693710199000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000421-201805000-00004"}},"subtitle":["Outcomes With Variable Adherence to Treatment"],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/coc.0000000000000300","relation":{},"ISSN":["0277-3732"],"issn-type":[{"value":"0277-3732","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}