{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T12:41:50Z","timestamp":1753274510616},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11]]},"abstract":"\n Objective:<\/jats:title>\n Cervical cancer presenting with metastases to the bony pelvis is rare. No available literature addresses the treatment and prognosis of these patients. Our objective was to review our experience treating women with this rare presentation.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We performed a review of all patients treated for cervical cancer at a single institution between January 1, 2007 and November 30, 2014. All patients had pretreatment imaging with computed tomography or positron emission tomography\/computed tomography. Included patients had evidence of pelvic bone metastases by imaging before initiation of treatment.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A total of 349 women were treated for cervical cancer during the study interval. Of these, 13 (3.7%) were identified as having pelvic bone metastases at initial presentation. Four of 13 patients had pelvic-confined disease and were treated with curative-intent radiation. The remainder had disseminated disease and were treated with palliative radiation. Only one complete response was seen. Seven patients received salvage chemotherapy. The median overall survival was 8.5 months. Survival was statistically similar in those who received palliative rather than curative radiotherapy (8.7 vs. 8.1\u2009mo, P<\/jats:italic>=0.76) and in those who received any postradiation chemotherapy (8.9 vs. 6.1\u2009mo, P<\/jats:italic>=0.066). Chemotherapy with bevacizumab resulted in the only 2 long-term survivors (both alive at 32.4 and 37.5\u2009mo). All others have died of disease.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Cervical cancer metastatic to the bony pelvis at initial presentation portends a dismal prognosis. Patients should be informed about this poor prognosis, and allowed to make an informed decision when considering curative-intent versus palliative treatment. Incorporation of bevacizumab appears to improve survival.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/coc.0000000000000439","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T01:19:38Z","timestamp":1520558378000},"page":"1137-1141","source":"Crossref","is-referenced-by-count":4,"title":["Emphasis on Systemic Therapy in Women With Pelvic Bone Metastasis at Time of Diagnosis of Cervical Cancer"],"prefix":"10.1097","volume":"41","author":[{"given":"Dustin B.","family":"Manders","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology"}]},{"given":"Travis T.","family":"Sims","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology"}]},{"given":"Kevin V.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX"}]},{"given":"Matthew J.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology"}]},{"given":"Debra L.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology"}]},{"given":"Siobhan M.","family":"Kehoe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology"}]},{"given":"David S.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology"}]},{"given":"Jayanthi S.","family":"Lea","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology"}]}],"member":"276","reference":[{"key":"R1-20230903","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1002\/1097-0142(19940501)73:9<2372::AID-CNCR2820730921>3.0.CO;2-E","article-title":"Bone metastasis from cervical cancer","volume":"73","author":"Ratanatharathorn","year":"1994","journal-title":"Cancer"},{"key":"R2-20230903","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0090-8258(85)90212-4","article-title":"Unusual skeletal metastases in carcinoma of the cervix","volume":"20","author":"Barmeir","year":"1985","journal-title":"Gynecol Oncol"},{"key":"R3-20230903","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/1097-0142(197508)36:2<475::AID-CNCR2820360226>3.0.CO;2-Q","article-title":"Bony metastases from carcinoma of cervix","volume":"36","author":"Blythe","year":"1975","journal-title":"Cancer"},{"key":"R4-20230903","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0090-8258(89)90853-6","article-title":"Bone metastasis from cervix cancer","volume":"32","author":"Matsuyama","year":"1989","journal-title":"Gynecol Oncol"},{"key":"R5-20230903","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0090-8258(90)90414-G","article-title":"Bone metastasis from gynecologic carcinomas: a clinicopathologic study","volume":"39","author":"Abdul-Karim","year":"1990","journal-title":"Gynecol Oncol"},{"key":"R6-20230903","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1097\/IGC.0b013e31829da127","article-title":"Contributing factors for bone metastasis in uterine cervical cancer","volume":"23","author":"Yoon","year":"2013","journal-title":"Int J Gynecol Cancer"},{"key":"R7-20230903","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/IGC.0b013e3181d4a0a1","article-title":"Bone metastasis in cervical cancer patients over a 10-year period","volume":"20","author":"Thanapprapasr","year":"2010","journal-title":"Int J Gynecol Cancer"},{"key":"R8-20230903","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0360-3016(87)90288-4","article-title":"Skeletal metastases from cancer of the uterine cervix: frequency, patterns, and radiotherapeutic significance","volume":"13","author":"Kim","year":"1987","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"R9-20230903","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0009-9260(82)80384-X","article-title":"Bony metastasis in carcinoma of the uterine cervix","volume":"33","author":"Bassan","year":"1982","journal-title":"Clin Radiol"},{"key":"R10-20230903","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4103\/0973-1482.25857","article-title":"Carcinoma of the uterine cervix with isolated metastasis to fibula and its unusual behavior: report of a case and review of literature","volume":"2","author":"Pasricha","year":"2006","journal-title":"J Cancer Res Ther"},{"key":"R11-20230903","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s00404-009-1307-6","article-title":"Femur metastasis in carcinoma of the uterine cervix: a rare entity","volume":"281","author":"Corrado","year":"2010","journal-title":"Arch Gynecol Obstet"},{"key":"R12-20230903","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/gyno.2002.6829","article-title":"Scalp metastasis in carcinoma of the uterine cervix \u2013 a rare entity","volume":"87","author":"Agarwal","year":"2002","journal-title":"Gynecol Oncol"},{"key":"R13-20230903","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0196-0709(99)90072-8","article-title":"Carcinoma of the uterine cervix metastatic to behind the zygomatic arch: a case report","volume":"20","author":"Challagalla","year":"1999","journal-title":"Am J Otolaryngol"},{"key":"R14-20230903","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.joms.2006.08.001","article-title":"Metastatic uterine cervical carcinoma of zygoma: a case report and review of the literature","volume":"64","author":"Granite","year":"2006","journal-title":"J Oral Maxillofac Surg"},{"key":"R15-20230903","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1447-0756.2007.00712.x","article-title":"Intractable recurrent cervical cancer with pelvic bone involvement successfully treated with external hemipelvectomy","volume":"34","author":"Hamanishi","year":"2008","journal-title":"J Obstet Gynaecol Res"},{"key":"R16-20230903","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.1002\/cncr.24599","article-title":"Detection of hematogenous bone metastasis in cervical cancer","volume":"115","author":"Liu","year":"2009","journal-title":"Cancer"},{"key":"R17-20230903","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1200\/JCO.2006.09.5281","article-title":"Palliative radiotherapy trials for bone metastases: a systematic review","volume":"25","author":"Chow","year":"2007","journal-title":"J Clin Oncol"},{"key":"R18-20230903","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s002560050200","article-title":"Pelvic insufficiency fractures associated with radiation atrophy: clinical recognition and diagnostic evaluation","volume":"26","author":"Mumber","year":"1997","journal-title":"Skeletal Radiol"},{"key":"R19-20230903","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ygyno.2012.02.009","article-title":"A multi-institutional phase II trial of paclitaxel and carboplatin in the treatment of advanced or recurrent cervical cancer","volume":"125","author":"Kitagawa","year":"2012","journal-title":"Gynecol Oncol"},{"key":"R20-20230903","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1056\/NEJMoa1309748","article-title":"Improved survival with Bevacizumab in advanced cervical cancer","volume":"370","author":"Tewari","year":"2014","journal-title":"N Engl J Med"}],"container-title":["American Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00000421-201811000-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T03:09:25Z","timestamp":1693710565000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000421-201811000-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/coc.0000000000000439","relation":{},"ISSN":["0277-3732"],"issn-type":[{"value":"0277-3732","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]}}}