{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:04:55Z","timestamp":1761843895598},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1097\/fjc.0b013e31819fd4e7","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T12:57:59Z","timestamp":1242910679000},"page":"373-378","source":"Crossref","is-referenced-by-count":65,"title":["Metformin Prevents Myocardial Reperfusion Injury by Activating the Adenosine Receptor"],"prefix":"10.1097","volume":"53","author":[{"given":"Marta","family":"Paiva","sequence":"first","affiliation":[]},{"given":"Niels P","family":"Riksen","sequence":"additional","affiliation":[]},{"given":"Sean M","family":"Davidson","sequence":"additional","affiliation":[]},{"given":"Derek J","family":"Hausenloy","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Monteiro","sequence":"additional","affiliation":[]},{"given":"Lino","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds","family":"Provid\u00eancia","sequence":"additional","affiliation":[]},{"given":"Gerard A","family":"Rongen","sequence":"additional","affiliation":[]},{"given":"Paul","family":"Smits","sequence":"additional","affiliation":[]},{"given":"Mihaela M","family":"Mocanu","sequence":"additional","affiliation":[]},{"given":"Derek M","family":"Yellon","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"key":"R1-5-20210208","doi-asserted-by":"crossref","first-page":"25","DOI":"10.7326\/0003-4819-137-1-200207020-00009","article-title":"Metformin: an update.","volume":"137","author":"Kirpichnikov","year":"2002","journal-title":"Ann Intern Med"},{"key":"R2-5-20210208","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0140-6736(98)07037-8","article-title":"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34).","volume":"352","year":"1998","journal-title":"Lancet"},{"key":"R3-5-20210208","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.2337\/diacare.25.12.2244","article-title":"Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes.","volume":"25","author":"Johnson","year":"2002","journal-title":"Diabetes Care"},{"key":"R4-5-20210208","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1055\/s-2002-26705","article-title":"Metformin improves cardiac functional recovery after ischemia in rats.","volume":"34","author":"Legtenberg","year":"2002","journal-title":"Horm Metab Res"},{"key":"R5-5-20210208","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00395-007-0691-y","article-title":"Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening.","volume":"103","author":"Bhamra","year":"2008","journal-title":"Basic Res Cardiol"},{"key":"R6-5-20210208","doi-asserted-by":"crossref","first-page":"696","DOI":"10.2337\/db07-1098","article-title":"Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling.","volume":"57","author":"Calvert","year":"2008","journal-title":"Diabetes"},{"key":"R7-5-20210208","doi-asserted-by":"crossref","first-page":"H457","DOI":"10.1152\/ajpheart.00002.2007","article-title":"Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.","volume":"293","author":"Zhang","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R8-5-20210208","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1432-1033.1986.tb09854.x","article-title":"Cytosolic adenylates and adenosine release in perfused working heart. Comparison of whole tissue with cytosolic non-aqueous fractionation analyses.","volume":"159","author":"Bunger","year":"1986","journal-title":"Eur J Biochem"},{"key":"R9-5-20210208","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1042\/bj2610541","article-title":"5-Nucleotidase activity and adenosine formation in stimulated, hypoxic and underperfused rat heart.","volume":"261","author":"Headrick","year":"1989","journal-title":"Biochem J"},{"key":"R10-5-20210208","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/physrev.00009.2003","article-title":"Preconditioning the myocardium: from cellular physiology to clinical cardiology.","volume":"83","author":"Yellon","year":"2003","journal-title":"Physiol Rev"},{"key":"R11-5-20210208","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.yjmcc.2003.12.008","article-title":"NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO.","volume":"36","author":"Yang","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"R12-5-20210208","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0008-6363(02)00455-8","article-title":"Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?","volume":"55","author":"Hausenloy","year":"2002","journal-title":"Cardiovasc Res"},{"key":"R13-5-20210208","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1161\/01.CIR.99.15.2041","article-title":"Quantification of extracellular and intracellular adenosine production: understanding the transmembranous concentration gradient.","volume":"99","author":"Deussen","year":"1999","journal-title":"Circulation"},{"key":"R14-5-20210208","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.cardiores.2003.09.025","article-title":"Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury.","volume":"60","author":"Hausenloy","year":"2003","journal-title":"Cardiovasc Res"},{"key":"R15-5-20210208","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/S0008-6363(96)88623-8","article-title":"An angiotensin II receptor antagonist attenuates left ventricular dilatation after myocardial infarction in the hypertensive rat.","volume":"29","author":"Nishikimi","year":"1995","journal-title":"Cardiovasc Res"},{"key":"R16-5-20210208","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2337\/diabetes.54.1.146","article-title":"Glucagon-like peptide 1 can directly protect the heart against ischemia\/reperfusion injury.","volume":"54","author":"Bose","year":"2005","journal-title":"Diabetes"},{"key":"R17-5-20210208","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/FPC.0b013e32803fb78f","article-title":"The 1976C T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo.","volume":"17","author":"Riksen","year":"2007","journal-title":"Pharmacogenet Genomics"},{"key":"R18-5-20210208","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/eurheartj\/ehm032","article-title":"Augmented hyperaemia and reduced tissue injury in response to ischaemia in subjects with the 34C T variant of the AMPD1 gene.","volume":"28","author":"Riksen","year":"2007","journal-title":"Eur Heart J"},{"key":"R19-5-20210208","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ijpharm.2007.01.001","article-title":"Effects of bacterial lipopolysaccharide on the pharmacokinetics of metformin in rats.","volume":"337","author":"Choi","year":"2007","journal-title":"Int J Pharm"},{"key":"R20-5-20210208","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1177\/009127009603601105","article-title":"Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus.","volume":"36","author":"Sambol","year":"1996","journal-title":"J Clin Pharmacol"},{"key":"R21-5-20210208","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.2337\/diabetes.51.7.2074","article-title":"Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.","volume":"51","author":"Musi","year":"2002","journal-title":"Diabetes"},{"key":"R22-5-20210208","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action.","volume":"108","author":"Zhou","year":"2001","journal-title":"J Clin Invest"},{"key":"R23-5-20210208","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s002100000318","article-title":"Metabolic flux rates of adenosine in the heart.","volume":"362","author":"Deussen","year":"2000","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"R24-5-20210208","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.pharmthera.2007.02.004","article-title":"Adenosinergic cardioprotection: multiple receptors, multiple pathways.","volume":"114","author":"Peart","year":"2007","journal-title":"Pharmacol Ther"},{"key":"R25-5-20210208","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1161\/01.CIR.0000143830.59419.73","article-title":"Optimal windows of statin use for immediate infarct limitation: 5-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase.","volume":"110","author":"Sanada","year":"2004","journal-title":"Circulation"},{"key":"R26-5-20210208","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0008-6363(01)00321-2","article-title":"Role of adenosine in ischemic preconditioning in rats depends critically on the duration of the stimulus and involves both A1 and A3 receptors.","volume":"51","author":"Liem","year":"2001","journal-title":"Cardiovasc Res"},{"key":"R27-5-20210208","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cardiores.2005.02.015","article-title":"Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine.","volume":"67","author":"Kin","year":"2005","journal-title":"Cardiovasc Res"},{"issue":"pt 1","key":"R28-5-20210208","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/clpt.1991.178","article-title":"Dose-dependent inhibition of the hemodynamic response to dipyridamole by caffeine.","volume":"50","author":"Smits","year":"1991","journal-title":"Clin Pharmacol Ther"},{"issue":"pt 2","key":"R29-5-20210208","first-page":"H1857","article-title":"Infarct size reduction with the nucleoside transport inhibitor R-75231 in swine.","volume":"272","author":"Martin","year":"1997","journal-title":"Am J Physiol"},{"key":"R30-5-20210208","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/FPC.0b013e328305e630","article-title":"The 22G A polymorphism in the adenosine deaminase gene impairs catalytic function but does not affect reactive hyperaemia in humans in vivo.","volume":"18","author":"Riksen","year":"2008","journal-title":"Pharmacogenet Genomics"},{"key":"R31-5-20210208","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1074\/jbc.275.1.223","article-title":"Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.","volume":"275","author":"El-Mir","year":"2000","journal-title":"J Biol Chem"},{"issue":"pt 3","key":"R32-5-20210208","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/bj3480607","article-title":"Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.","volume":"348","author":"Owen","year":"2000","journal-title":"Biochem J"},{"key":"R33-5-20210208","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/01.CIR.0000151612.02223.F2","article-title":"Annexin A5 scintigraphy of forearm as a novel in vivo model of skeletal muscle preconditioning in humans.","volume":"111","author":"Rongen","year":"2005","journal-title":"Circulation"}],"container-title":["Journal of Cardiovascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00005344-200905000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T01:45:04Z","timestamp":1618364704000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00005344-200905000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/fjc.0b013e31819fd4e7","relation":{},"ISSN":["0160-2446"],"issn-type":[{"value":"0160-2446","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}