{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:29:09Z","timestamp":1759336149342,"version":"3.41.0"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective:<\/jats:title><jats:p>Prevention or induction of metabolic disorders and obesity depend on estrogen signaling and\/or exogenous factors, such as mineral content in diet. The protective effects of a Portuguese natural mineral-rich water against the induction of metabolic syndrome in fructose-fed male Sprague-Dawley rats have been reported. The present study was designed to assess the impact of this mineral-rich water on fructose-fed estrogen-deficient female Sprague-Dawley rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Ovariectomized rats had access to tap (TWO) or mineral-rich (MWO) waters, with and without 10% fructose (10-wk treatment). A sham-operated (tap water supplied) group was included and each of the five groups included six rats. Plasma biochemical and metabolic parameters were evaluated by routine clinical measurements. Western blotting was used to assess hepatic protein expression of sirtuins (Sirt) 1 and 3, phosphorylated AMP-activated protein kinase-\u03b1 (p-AMPK\u03b1), peroxisome proliferator-activated receptor gamma coactivator-1-\u03b1 (PGC1\u03b1), glucocorticoid receptor, and 11beta-hydroxysteroid dehydrogenase type 1 (11\u03b2HSD1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Ovariectomy increased plasma total cholesterol (46%\/<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a&lt;\u200a0.05), but had no significant effects on hepatic protein expression. Fructose intake by ovariectomized rats increased PGC1\u03b1 and 11\u03b2HSD1 (fructose in tap water [TWFO] vs TWO: 65%\/<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a&lt;\u200a0.05 and 38%\/<jats:italic toggle=\"yes\">P<\/jats:italic>= 0.05, respectively) as well as glucocorticoid receptor (TWFO and fructose in natural mineral-rich water [MWFO] vs TWO and MWO: 107%\/<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a0.05 and 182%\/<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a&lt;\u200a0.05, respectively). Mineral-rich water ingestion exerted an increasing shape on Sirt1 (MWO vs TWO: 76%\/<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a&lt;\u200a0.05; MWFO vs TWFO: 76%\/<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a0.06), PGC1\u03b1 (MWO vs TWO: 77%\/<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a&lt;\u200a0.01), p-AMPK\u03b1 (MWO vs TWO: 152%\/<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a0.01; MWFO vs TWFO: 107%\/<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a0.01), and 11\u03b2HSD1 (MWO vs TWO: 91%\/<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a0.05; MWFO vs TWFO: 47%\/<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Mineral-rich water ingestion may have a prime role on the activation of Sirt1 signaling and the modulation of glucocorticoid signaling in the postmenopause.<\/jats:p><\/jats:sec>","DOI":"10.1097\/gme.0000000000000780","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T10:58:51Z","timestamp":1480417131000},"page":"563-573","source":"Crossref","is-referenced-by-count":6,"title":["Natural mineral-rich water ingestion by ovariectomized fructose-fed Sprague-Dawley rats: effects on sirtuin 1 and glucocorticoid signaling pathways"],"prefix":"10.1097","volume":"24","author":[{"given":"Jugal Kishore","family":"Das","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"School of Biotechnology, KIIT University, Bhubaneswar, India"}]},{"given":"Milton","family":"Severo","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Predictive Medicine and Public Health, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Unidade de Investiga\u00e7\u00e3o em Epidemiologia (EPIUnit), Instituto de Sa\u00fade P\u00fablica, University of Porto, Porto, Portugal"}]},{"given":"Cid\u00e1lia Dion\u00edsio","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Escola Superior de Sa\u00fade, Instituto Polit\u00e9cnico de Leiria, Campus 2 - Morro de Lena - Alto do Vieiro, Leiria, Portugal"}]},{"given":"Em\u00edlia","family":"Patr\u00edcio","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department of S\u00e3o Jo\u00e3o Hospital Centre, Porto, Portugal"}]},{"given":"Jos\u00e9","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"CIAFEL - Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal"}]},{"given":"Ros\u00e1rio","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3 s), University of Porto, Porto, Portugal"}]},{"given":"Delminda","family":"Neves","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3 s), University of Porto, Porto, Portugal"},{"name":"Department of Experimental Biology, Faculty of Medicine, University of Porto, Porto, Portugal."}]},{"given":"Maria Jo\u00e3o","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3 s), University of Porto, Porto, Portugal"}]}],"member":"276","reference":[{"key":"R1-20230814","first-page":"132","article-title":"Understanding the metabolic syndrome using a biomedical chemistry profile","author":"Pereira","year":"2015","journal-title":"Biomedical Chemistry 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