{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:53:45Z","timestamp":1761562425622},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5]]},"abstract":"\n Purpose:<\/jats:title>\n This pilot study aimed to compare physiological responses between cycle cardiopulmonary exercise tests (CPETs) and 6-min walk tests (6MWTs) and to assess their prognostic value among patients with idiopathic pulmonary fibrosis (IPF).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Thirty-four patients with IPF (68 \u00b1 8 yr) underwent CPETs and 6MWTs and were followed up for 40 mo. Differences, levels of agreement, and relative risks for mortality were analyzed between measured and estimated peak responses for the 2 tests.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Compared with the CPET, oxygen uptake (\n \n \n \n JOURNAL\/jcprh\/04.03\/01273116-201905000-00010\/10FSM1\/v\/2023-09-11T074705Z\/r\/image-gif\n \n \n \n \n o<\/jats:sc>\n 2<\/jats:sub>), heart rate (HR), and the nadir of SpO<\/jats:sc>\n 2<\/jats:sub> were lower during the 6MWT, whereas work rate (WR) was higher. Mean differences were as follows: \n \n \n \n JOURNAL\/jcprh\/04.03\/01273116-201905000-00010\/10FSM1\/v\/2023-09-11T074705Z\/r\/image-gif\n \n \n \n \n o<\/jats:sc>\n 2<\/jats:sub> =\u22121.9 mL\/kg\/min, 95% CI, \u22121.1 to \u22122.7, P<\/jats:italic> < .001; HR =\u22129 beats\/min, 95% CI, \u22124 to \u221214, P<\/jats:italic> = .002; SpO<\/jats:sc>\n 2<\/jats:sub> =\u22126%, 95% CI, \u22124 to \u22127, P<\/jats:italic> < .001; and WR = 9 W\/min, 95% CI, 3 to 16, P<\/jats:italic> = .008. Interclass correlations ranged from 0.84 to 0.90 and both tests demonstrated prognostic value for mortality.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Significant differences and variation in peak physiological responses were observed between cycle CPETs and 6MWTs in patients with IPF. However, good agreement was evident, suggesting that both tests provide value for clinical and research settings. Future studies should compare the physiological responses between treadmill CPETs and 6MWTs for prognostic utility in IPF.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/hcr.0000000000000362","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T15:41:13Z","timestamp":1538581273000},"page":"193-198","source":"Crossref","is-referenced-by-count":6,"title":["Physiological Responses and Prognostic Value of Common Exercise Testing Modalities in Idiopathic Pulmonary Fibrosis"],"prefix":"10.1097","volume":"39","author":[{"given":"Baruch","family":"Vainshelboim","sequence":"first","affiliation":[]},{"given":"Jonathan","family":"Myers","sequence":"additional","affiliation":[]},{"given":"Jose","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Shimon","family":"Izhakian","sequence":"additional","affiliation":[]},{"given":"Avraham","family":"Unterman","sequence":"additional","affiliation":[]},{"given":"Mordechai Reuven","family":"Kramer","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"issue":"1","key":"R1-20230911","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","article-title":"ATS statement: guidelines for the six-minute walk test","volume":"166","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"R2-20230911","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/rccm.167.2.211","article-title":"ATS\/ACCP Statement on cardiopulmonary exercise testing","volume":"167","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"R3-20230911","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/CIRCULATIONAHA.109.914788","article-title":"Cardiopulmonary exercise testing in the clinical evaluation of patients with heart and lung disease","volume":"123","author":"Arena","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"R4-20230911","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000186694","article-title":"Cardiopulmonary exercise testing in the functional and prognostic evaluation of patients with pulmonary diseases","volume":"77","author":"Ferrazza","year":"2009","journal-title":"Respiration"},{"issue":"2","key":"R5-20230911","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/CIR.0b013e3181e52e69","article-title":"Clinician's Guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association","volume":"122","author":"Balady","year":"2010","journal-title":"Circulation"},{"issue":"18","key":"R6-20230911","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1161\/CIR.0b013e31826fb946","article-title":"EACPR\/AHA Scientific Statement. 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