{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:41:20Z","timestamp":1776267680582,"version":"3.50.1"},"reference-count":148,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/ http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>In the last decade, research into human hepatology has been revolutionized by the development of mini human livers in a dish. These liver organoids are formed by self-organizing stem cells and resemble their native counterparts in cellular content, multicellular architecture, and functional features. Liver organoids can be derived from the liver tissue or pluripotent stem cells generated from a skin biopsy, blood cells, or renal epithelial cells present in urine. With the development of liver organoids, a large part of previous hurdles in modeling the human liver is likely to be solved, enabling possibilities to better model liver disease, improve (personalized) drug testing, and advance bioengineering options. In this review, we address strategies to generate and use organoids in human liver disease modeling, followed by a discussion of their potential application in drug development and therapeutics, as well as their strengths and limitations.<\/jats:p>","DOI":"10.1097\/hep.0000000000000343","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T05:00:25Z","timestamp":1677128425000},"page":"1432-1451","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":39,"title":["Human liver organoids: From generation to applications"],"prefix":"10.1097","volume":"79","author":[{"given":"Marta B.","family":"Afonso","sequence":"first","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal"}]},{"given":"Vanda","family":"Marques","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal"}]},{"given":"Saskia W.C.","family":"van Mil","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, University Medical Center Utrecht and Utrecht University, The Netherlands"}]},{"given":"Cecilia M.P.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal"}]}],"member":"276","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"R1-20250824","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00204-020-02937-6","article-title":"Comparing in vitro human liver models to in vivo human liver using RNA-Seq","volume":"95","author":"Gupta","year":"2021","journal-title":"Arch Toxicol"},{"key":"R2-20250824","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.jhep.2022.06.022","article-title":"2D and 3D liver models","volume":"78","author":"Saxton","year":"2023","journal-title":"J 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