{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T23:05:28Z","timestamp":1756076728868,"version":"3.44.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n            <jats:title>Background and Aims:<\/jats:title>\n            <jats:p>Since the introduction of SARS-CoV-2 vaccines, several cases of vaccine-induced immune thrombocytopenia and thrombosis (VITT) have been described, especially cerebral vein thrombosis. We aimed to retrospectively collect all new cases of acute onset first or recurrent splanchnic vein thrombosis (SVT) following a recent SARS-CoV-2 vaccination within the Vascular Liver Disease Group network.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results:<\/jats:title>\n            <jats:p>New cases of SVT were identified from April 2021 to April 2022; follow-up was completed on December 31, 2022. Criteria to define VITT were derived from previous studies. Data from a pre-COVID cohort of patients with SVT (N=436) were used for comparison of clinical presentation, etiology, and outcome. Twenty-nine patients were identified with SVT occurring with a median of 11 days (range 2\u201376) after the first (48%), second (41%), or third (10%) vaccination (ChAdOx1 nCov-19 (n=12) or BNT162b2 (n=14), other (n=3) Only 2 patients(7%) fulfilled criteria for definite VITT. Twenty (69%) had SVT at multiple sites, including 4 (14%) with concomitant extra-abdominal thrombosis. Only 28% had an underlying prothrombotic condition, compared to 52% in the pre-COVID SVT cohort (<jats:italic toggle=\"yes\">p<\/jats:italic>=0.01). Five patients (17%) underwent bowel resection for mesenteric ischemia, compared with 3% in pre-COVID SVT (<jats:italic toggle=\"yes\">p<\/jats:italic>&lt;0.001). Two patients died shortly after diagnosis (7%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Although definite VITT was rare, in 72% of cases, no other cause for SVT could be identified following SARS-CoV-2 vaccination. These cases were different from patients with nonvaccine\u2013related SVT, with lower incidence of prothrombotic conditions, higher rates of bowel ischemia, and poorer outcome. Although SVT after SARS-CoV-2 vaccination is rare in absolute terms, these data remain relevant considering ongoing revaccination programs.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/hep.0000000000000787","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T12:00:32Z","timestamp":1707998432000},"page":"1147-1157","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Extensive splanchnic vein thrombosis after SARS-CoV-2 vaccination: A Vascular Liver Disease Group (VALDIG) initiative"],"prefix":"10.1097","volume":"80","author":[{"given":"Raoel","family":"Maan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands"}]},{"given":"Mandy N.","family":"Lauw","sequence":"additional","affiliation":[{"name":"Department of Hematology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands"}]},{"given":"Loise","family":"China","sequence":"additional","affiliation":[{"name":"Institute of Liver and Digestive Health, University College London, United Kingdom"}]},{"given":"David","family":"Patch","sequence":"additional","affiliation":[{"name":"Hepatology and Liver Transplantation, Royal Free London NHS Foundation Trust, London, United Kingdom"}]},{"given":"Anna","family":"Baiges","sequence":"additional","affiliation":[{"name":"v Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Cl\u00ednic Barcelona, Institut de Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona. CIBEREHD (Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas)"}]},{"given":"Juan Carlos","family":"Garcia-Pagan","sequence":"additional","affiliation":[{"name":"v Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Cl\u00ednic Barcelona, Institut de Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona. CIBEREHD (Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas)"}]},{"given":"Virginia","family":"Hern\u00e1ndez-Gea","sequence":"additional","affiliation":[{"name":"v Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Cl\u00ednic Barcelona, Institut de Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona. CIBEREHD (Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas)"}]},{"given":"Marie-Noelle","family":"Hilleret","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato-Gastroent\u00e9rologie, CHU Grenoble Alpes, 38043 Grenoble Cedex, France"}]},{"given":"Eric T.","family":"Tjwa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands"}]},{"given":"Ilias","family":"Kounis","sequence":"additional","affiliation":[{"name":"AP-HP H\u00f4pital Paul-Brousse, Centre H\u00e9pato-Biliaire ; Inserm, Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Saclay, Inserm, Physiopathog\u00e9n\u00e8se et traitement des maladies du Foie, FHU Hepatinov, Villejuif, France"}]},{"given":"Christophe","family":"Bureau","sequence":"additional","affiliation":[{"name":"University Hospital of Toulouse and Toulouse III Paul Sabatier University, Toulouse, France"}]},{"given":"Baptiste","family":"Giguet","sequence":"additional","affiliation":[{"name":"Liver Disease Department, CHU Rennes, Univ Rennes, Rennes, France"}]},{"given":"Alexandra","family":"Heurgu\u00e9","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastroenterology, CHU Reims, Reims, France"}]},{"given":"Isabelle","family":"Ollivier-Hourmand","sequence":"additional","affiliation":[{"name":"Department of hepatology and gastroenterology, University Hospital, C\u00f4te de Nacre, Caen, France"}]},{"given":"Xavier","family":"Causse","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology, Orleans, France"}]},{"given":"Filipe","family":"Nery","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio, Porto, Portugal"},{"name":"EpiUnit, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto, Porto, Portugal"}]},{"given":"Ahad","family":"Eshraghian","sequence":"additional","affiliation":[{"name":"Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz, Iran"}]},{"given":"Aur\u00e9lie","family":"Plessier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, AP-HP, H\u00f4pital Beaujon, Service d\u2019H\u00e9patologie, DMU DIGEST, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, FILFOIE, Centre de recherche sur l\u2019inflammation, Inserm, Paris, France"}]},{"given":"Sarwa","family":"Darwish Murad","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands"}]}],"member":"276","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"R1-20250824","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1056\/NEJMoa2109908","article-title":"Clinical features of vaccine-induced immune thrombocytopenia and 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