{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T14:30:39Z","timestamp":1769092239510,"version":"3.49.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>Hypertension management is directed by cuff blood pressure (BP), but this may be inaccurate, potentially influencing cardiovascular disease (CVD) events and health costs. This study aimed to determine the impact on CVD events and related costs of the differences between cuff and invasive SBP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Microsimulations based on Markov modelling over one year were used to determine the differences in the number of CVD events (myocardial infarction or coronary death, stroke, atrial fibrillation or heart failure) predicted by Framingham risk and total CVD health costs based on cuff SBP compared with invasive (aortic) SBP. Modelling was based on international consortium data from 1678 participants undergoing cardiac catheterization and 30 separate studies. Cuff underestimation and overestimation were defined as cuff SBP less than invasive SBP and cuff SBP greater than invasive SBP, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The proportion of people with cuff SBP underestimation versus overestimation progressively increased as SBP increased. This reached a maximum ratio of 16\u200a:\u200a1 in people with hypertension grades II and III. Both the number of CVD events missed (predominantly stroke, coronary death and myocardial infarction) and associated health costs increased stepwise across levels of SBP control, as cuff SBP underestimation increased. The maximum number of CVD events potentially missed (11.8\/1000 patients) and highest costs ($241\u200a300\u200aUSD\/1000 patients) were seen in people with hypertension grades II and III and with at least 15\u200ammHg of cuff SBP underestimation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Cuff SBP underestimation can result in potentially preventable CVD events being missed and major increases in health costs. These issues could be remedied with improved cuff SBP accuracy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/hjh.0000000000003510","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T10:02:30Z","timestamp":1689760950000},"page":"1585-1594","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Cardiovascular and health cost impacts of cuff blood pressure underestimation and overestimation of invasive aortic systolic blood pressure"],"prefix":"10.1097","volume":"41","author":[{"given":"Ricardo","family":"Fonseca","sequence":"first","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania"}]},{"given":"Andrew J.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania"}]},{"given":"Dean S.","family":"Picone","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania"}]},{"given":"Ingrid A.","family":"Cox","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania"}]},{"given":"Martin G.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania"}]},{"given":"J. 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Taiwan"}]},{"given":"Chen-Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine"}]},{"given":"Antoine","family":"Cremer","sequence":"additional","affiliation":[{"name":"Department of Cardiology\/Hypertension, University Hospital of Bordeaux, Bordeaux, France"}]},{"given":"Nathan","family":"Dwyer","sequence":"additional","affiliation":[{"name":"Royal Hobart Hospital, Hobart, Australia"}]},{"given":"Alun D.","family":"Hughes","sequence":"additional","affiliation":[{"name":"MRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Sciences, University College London"}]},{"given":"Peter","family":"Lacy","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences University College London (UCL) and National Institute for Health Research (NIHR) UCL\/UCL Hospitals Biomedical Research Centre, London, United Kingdom"}]},{"given":"Stefano","family":"Omboni","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Italian Institute of Telemedicine, Varese, Italy"},{"name":"Department of Cardiology, Sechenov First Moscow State Medical University, Moscow, Russian Federation"}]},{"given":"Christian","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, Erlangen, Germany"}]},{"given":"Telmo","family":"Pereira","sequence":"additional","affiliation":[{"name":"Polytechnic Institute of Coimbra, Coimbra Health School"},{"name":"Laboratory for Applied Health Research (LabinSa\u00fade), Rua 5 de Outubro-SM Bispo, Coimbra, Portugal"}]},{"given":"Giacomo","family":"Pucci","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine at Terni University Hospital, Department of Medicine, University of Perugia, Perugia, Italy"}]},{"given":"Roland","family":"Schmieder","sequence":"additional","affiliation":[{"name":"Department of Nephrology and 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