{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T02:36:36Z","timestamp":1776479796727,"version":"3.51.2"},"reference-count":137,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Neutropenia, as an isolated blood cell deficiency, is a feature of a wide spectrum of acquired or congenital, benign or premalignant disorders with a predisposition to develop myelodysplastic neoplasms\/acute myeloid leukemia that may arise at any age. In recent years, advances in diagnostic methodologies, particularly in the field of genomics, have revealed novel genes and mechanisms responsible for etiology and disease evolution and opened new perspectives for tailored treatment. Despite the research and diagnostic advances in the field, real world evidence, arising from international neutropenia patient registries and scientific networks, has shown that the diagnosis and management of neutropenic patients is mostly based on the physicians\u2019 experience and local practices. Therefore, experts participating in the European Network for the Innovative Diagnosis and Treatment of Chronic Neutropenias have collaborated under the auspices of the European Hematology Association to produce recommendations for the diagnosis and management of patients across the whole spectrum of chronic neutropenias. In the present article, we describe evidence- and consensus-based guidelines for the definition and classification, diagnosis, and follow-up of patients with chronic neutropenias including special entities such as pregnancy and the neonatal period. We particularly emphasize the importance of combining the clinical findings with classical and novel laboratory testing, and advanced germline and\/or somatic mutational analyses, for the characterization, risk stratification, and monitoring of the entire spectrum of neutropenia patients. We believe that the wide clinical use of these practical recommendations will be particularly beneficial for patients, families, and treating physicians.<\/jats:p>","DOI":"10.1097\/hs9.0000000000000872","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T15:21:56Z","timestamp":1680189716000},"page":"e872","source":"Crossref","is-referenced-by-count":67,"title":["The European Guidelines on Diagnosis and Management of Neutropenia in Adults and Children: A Consensus Between the European Hematology Association and the EuNet-INNOCHRON COST Action"],"prefix":"10.1002","volume":"7","author":[{"given":"Francesca","family":"Fioredda","sequence":"first","affiliation":[{"name":"Unit of Hematology, IRCCS Istituto Giannina Gaslini, Genova, Italy"}]},{"given":"Julia","family":"Skokowa","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology, Immunology, Rheumatology, and Clinical Immunology, University Hospital T\u00fcbingen, Germany"}]},{"given":"Hannah","family":"Tamary","sequence":"additional","affiliation":[{"name":"The Rina Zaizov Hematology\/Oncology Division, Schneider Children\u2019s Medical Center of Israel, Petah Tikva, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Israel"}]},{"given":"Michail","family":"Spanoudakis","sequence":"additional","affiliation":[{"name":"Department of Hematology, Warrington and Halton Teaching Hospitals NHS foundation Trust, Warrington, United Kingdom"}]},{"given":"Piero","family":"Farruggia","sequence":"additional","affiliation":[{"name":"Pediatric Onco-Hematology, ARNAS Civico Di Cristina Benfratelli Hospital, Palermo, Italy"}]},{"given":"Antonio","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital da Luz Lisboa, Portugal"},{"name":"Faculdade de Medicina, Universidade Cat\u00f3lica Portuguesa, Lisbon, Portugal"}]},{"given":"Daniela","family":"Guardo","sequence":"additional","affiliation":[{"name":"Unit of Hematology, IRCCS Istituto Giannina Gaslini, Genova, Italy"}]},{"given":"Petter","family":"H\u00f6glund","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Transfusion Medicine Clinic, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Center for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Hematology, Karolinska University Hospital, Stockholm, Sweden"}]},{"given":"Peter E.","family":"Newburger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UMass Chan Medical School, Worcester, MA, USA"}]},{"given":"Jan","family":"Palmblad","sequence":"additional","affiliation":[{"name":"Center for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Hematology, Karolinska University Hospital, Stockholm, Sweden"}]},{"given":"Ivo P.","family":"Touw","sequence":"additional","affiliation":[{"name":"Department of Hematology and Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands"}]},{"given":"Cornelia","family":"Zeidler","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology, Immunology and Bone Marrow Transplantation, Hannover Medical School, Hannover, Germany"}]},{"given":"Alan J.","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Hematology, University of Cambridge, United Kingdom"},{"name":"Cambridge Institute for Medical Research, University of Cambridge, United Kingdom"},{"name":"Wellcome Trust\u2013Medical Research Council Stem Cell Institute, University of Cambridge, United Kingdom"}]},{"given":"David C.","family":"Dale","sequence":"additional","affiliation":[{"name":"University of Washington, Seattle, WA, 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